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Shire plc: Core Portfolio of Products Delivers 20% Sales Growth
Date:8/5/2009

With Q2 launches in France and Portugal, FIRAZYR is now launched in nine countries, including four of the five largest European countries. FIRAZYR also received final price publication in Italy during June, which will enable launch in Italy during Q3. FIRAZYR is the first new product for HAE in Europe in 30 years and has orphan exclusivity in the EU until 2018.

3. Royalties

Royalty revenue increased by 3% to $66.9 million for the three months to June 30, 2009 (2008: $64.8 million). The following table provides an analysis of Shire's royalty income:

    Product              Royalties to Shire $M  Year on year change(1)
    3TC                          29.2                   -18%
    ZEFFIX                       10.2                    -6%
    ADDERALL XR                  13.6                   n/a
    Other                        13.9                   -25%
    Total                        66.9                     3%

    (1) Compared with Q2 2008
    3TC - HIV infection and AIDS

Shire receives royalties from GSK on worldwide sales of 3TC(R) sales. Royalties from sales of 3TC for the three months to June 30, 2009 were $29.2 million (2008: $35.6 million). Excluding unfavorable foreign exchange movements of 7%, royalties have decreased by 11% mainly due to competition from other HIV treatments.

ZEFFIX - Chronic hepatitis B infection

Shire receives royalties from GSK on worldwide ZEFFIX(R) sales. Royalties from sales of ZEFFIX for the three months to June 30, 2009 were $10.2 million, a decrease of 6% (2008: $10.8 million). The impact of foreign exchange movements has contributed 4% to the reported decrease, with the remainder of the decrease due to increased competition from other hepatitis B treatments.

ADDERALL XR - ADHD

Royalties from Teva's sales of authorized generic ADDERALL XR for the three months to June 30, 2009 were $13.6 m
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SOURCE Shire Plc
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