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Shire plc: Continued Strong Product Sales Performance in Q3: On Track to Deliver Significant 2011 Earnings Growth
Date:10/28/2011

ty in (earnings)/losses of equity method investees (0.8) 0.3 (3.2) (0.2) Changes in operating assets and liabilities: Increase in accounts receivable (66.7) (94.1) (122.8) (138.0) (Decrease)/increase in sales deduction accrual (19.9) 14.8 46.2 169.0 Increase in inventory (12.2) (4.1) (42.8) (54.1) Decrease/(increase) in prepayments and other assets 31.1 16.2 17.3 (67.0) (Decrease)/increase in accounts payable and other liabilities (24.3) 2.3 (101.4) (41.0) Returns on investment from joint venture 5.2 5.8 5.2 5.8 Net cash provided by operating activities(A) 178.7 142.0 664.2 612.0

Unaudited US GAAP results for the three months and nine months to September 30, 2011
Consolidated Statements of Cash Flows (continued)

3 months to September 9 months to September 30, 30, 2011 2010 2011 2010 $M $M $M $M CASH FLOWS FROM INVESTING ACTIVITIES: Movements in restricted cash 0.9 (553.0) 5.7 (547.0) Purchases of subsidiary undertakings, net of cash acquired (3.8) - (723.5) - Payments on foreign exchange contracts related to Movetis - (21.2) - (21.2) Purchases of non-current investments (3.8) (1.0) (8.3) (1.0) Purchases of property, plant and equipment ("PP&E") (40.9) (53.5) (135.9) (261.7) Purchases of intangible assets (5.2) - (5.2) (2.7) Proceeds from disposal of non-current investments and PP&E 94.7 - 94.7 2.1 Proceeds/deposits received on sales of product rights 1.9 - 8.8 - Returns of equity investments and proceeds from short term investments 0.1 - 1.7 - Net cash provided by/(used in) investing activities(B) 43.9 (628.7) (762.0) (831.5) CASH FLOWS FROM FINANCING ACTIVITIES: Proceeds from drawing of revolving credit facility - - 30.0 - Repayment of revolving credit facility (30.0) - (30.0) - Repayment of debt acquired with ABH - - (13.1) - Payment under building finance obligation (0.6) (0.4) (1.0) (1.8) Extinguishment of building finance obligation - - - (43.1) Tax benefit of stock based compensat
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