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Shire plc: Continued Strong Product Sales Performance in Q3: On Track to Deliver Significant 2011 Earnings Growth
Date:10/28/2011

lue; 1,000 million shares authorized; and 562.5 million shares issued and outstanding (2010: 1,000 million shares authorized; and 562.2 million shares issued and outstanding) 55.7 55.7 Additional paid-in capital 2,824.5 2,746.4 Treasury stock: 12.5 million shares (2010: 14.0 million) (293.1) (276.1) Accumulated other comprehensive income 88.5 85.7 Retained earnings/(accumulated deficit) 279.1 (160.3) Total equity 2,954.7 2,451.4 Total liabilities and equity 6,065.6 5,387.6

Unaudited US GAAP results for the three months and nine months to September 30, 2011
Consolidated Statements of Income

9 months 3 months to 3 months to 9 months to to September September September September 30, 30, 30, 30, 2011 2010 2011 2010 $M $M $M $M Revenues: Product sales 1,018.4 794.3 2,901.0 2,276.8 Royalties 62.8 76.5 199.8 254.5 Other revenues 4.9 3.5 20.4 8.6 Total revenues 1,086.1 874.3 3,121.2 2,539.9 Costs and expenses: Cost of product sales(1) 166.5 112.7 434.7 333.7 Research and development(1) 201.5 197.9 556.3 475.9 Selling, general and administrative(1) 452.1 392.4 1,295.3 1,106.7 Loss/(gain) on sale of product rights 0.3 - 3.8 (4.1) Reorganization costs 5.0 9.7 18.0 23.3 Integration and acquisition costs 5.3 5.8 7.9 6.4 Total operating expenses 830.7 718.5 2,316.0 1,941.9 Operating income 255.4 155.8 805.2 598.0 Interest income 0.3 1.0 1.5 1.9 Interest expense (9.7) (8.3) (28.8) (25.6) Other income, net 15.6 0.8 15.9 9.0 Total other income/(expense), net 6.2 (6.5) (11.4) (14.7) Income before income taxes and equity in earnings/(losses) of equity method investees 261.6 149.3 793.8 583.3 Income taxes (69.5) (52.7) (187.3) (160.8) Equity in earnings/(losses) of equity method investees, net of taxes 0.8 (0.3) 3.2 0.2 Net income 192.9 96.3 609.7 422.7

(1) Cost of product sales includes amortization of intangible assets relating to favorable manufacturing contracts of $0.5 million f
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