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Shire plc: Continued Excellent Performance in Q3, Full Year Earnings Expectations Increased, New Value in Pipeline Emerging
Date:10/29/2010

s (0.3) 0.6 0.2 1.0 Income from continuing operations, net of tax 96.3 59.6 422.7 329.5 Loss from discontinued operations (net of income tax expense of $nil in all periods) - - - (12.4) Net income 96.3 59.6 422.7 317.1 Add: Net loss attributable to noncontrolling interest in subsidiaries - - - 0.2 Net income attributable to Shire plc 96.3 59.6 422.7 317.3

(1) Cost of product sales includes amortization of intangible assets relating to favorable manufacturing contracts of $0.4 million for the three months to September 30, 2010 (2009: $0.4 million) and $1.3 million for the nine months to September 30, 2010 (2009: $1.3 million). Selling, general and administrative costs include amortization and impairment charges of intangible assets relating to intellectual property rights acquired of $73.9 million for the three months to September 30, 2010 (2009: $34.8 million) and $142.3 million for the nine months to September 30, 2010 (2009: $101.6 million).

Unaudited US GAAP results for the three months and nine months to September 30, 2010 Consolidated Statements of Income (continued)

9 months 9 months 3 months to 3 months to to to September September September 30, September 30, 30, 30, 2010 2009 2010 2009 Earnings per ordinary share - basic Earnings from continuing operations 17.6c 11.0c 77.4c 61.1c Loss from discontinued operations - - - (2.3c) Earnings per ordinary share - basic 17.6c 11.0c 77.4c 58.8c Earnings per ADS - basic 52.8c 33.0c 232.2c 176.4c Earnings per ordinary share - diluted Earnings from continuing operations 17.3c 10.9c 76.0c 60.3c Loss from discontinued operations - - - (2.3c) Earnings per ordinary share - diluted 17.3c 10.9c 76.0c 58.0c Earnings per ADS - diluted 51.9c 32.7c 228.0c 174.0c Weighted average number of shares (millions): Basic 547.0 540.6 546.1 540.0 Diluted 556.7 548.3 589.7 547.1

Unaudited US GAAP results for the three months and nine months to S
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SOURCE Shire plc
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