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Shire plc: Continued Excellent Performance in Q3, Full Year Earnings Expectations Increased, New Value in Pipeline Emerging
Date:10/29/2010

Total current liabilities 1,171.2 1,020.0 Non-current liabilities: Convertible bonds 1,100.0 1,100.0 Other long-term debt 6.8 43.6 Deferred tax liability 356.1 294.3 Other non-current liabilities 169.7 247.1 Total liabilities 2,803.8 2,705.0 Equity: Common stock of 5p par value; 1,000 million shares authorized; and 562.2 million shares issued and outstanding (2009: 1,000 million shares authorized; and 561.5 million shares issued and outstanding) 55.7 55.6 Additional paid-in capital 2,731.9 2,677.6 Treasury stock: 14.9 million shares (2009: 17.8 million) (299.0) (347.4) Accumulated other comprehensive income 108.6 149.1 Accumulated deficit (299.4) (622.4) Total equity 2,297.8 1,912.5 Total liabilities and equity 5,101.6 4,617.5

Unaudited US GAAP results for the three months and nine months to September 30, 2010 Consolidated Statements of Income

9 months 9 months 3 months to 3 months to to to September September September 30, September 30, 30, 30, 2010 2009 2010 2009 $M $M $M $M Revenues: Product sales 794.3 602.5 2,276.8 1,916.8 Royalties 76.5 60.3 254.5 177.8 Other revenues 3.5 4.2 8.6 19.8 Total revenues 874.3 667.0 2,539.9 2,114.4 Costs and expenses: Cost of product sales(1) 112.7 104.9 333.7 284.9 Research and development 197.9 147.8 475.9 492.5 Selling, general and administrative(1) 392.4 320.6 1,106.7 973.8 Gain on sale of product rights - (6.3) (4.1) (6.3) Reorganization costs 9.7 2.0 23.3 7.1 Integration and acquisition costs 5.8 6.2 6.4 10.0 Total operating expenses 718.5 575.2 1,941.9 1,762.0 Operating income 155.8 91.8 598.0 352.4 Interest income 1.0 0.2 1.9 1.5 Interest expense (8.3) (9.4) (25.6) (30.6) Other income, net 0.8 7.0 9.0 61.9 Total other (expense)/income, net (6.5) (2.2) (14.7) 32.8 Income from continuing operations before income taxes and equity in (losses)/earnings of equity method investees 149.3 89.6 583.3 385.2 Income taxes (52.7) (30.6) (160.8) (56.7) Equity in (losses)/earnings of equity method investees, net of taxe
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