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Shire plc: Continued Excellent Performance in Q3, Full Year Earnings Expectations Increased, New Value in Pipeline Emerging
Date:10/29/2010

was directed to all three Orange Book listed patents for INTUNIV. ADDITIONAL INFORMATION The following additional information is included in this press release: Page Overview of Q3 2010 Financial Results 8 Financial Information 12 Notes to Editors 25 Safe Harbor Statement 25 Explanation of Non GAAP Measures 26 Trademarks 27

Dial in details for the live conference call for investors 14:00 BST/9:00 EDT on October 29, 2010:

UK dial in: 0844-335-0351 US dial in: 1-866-8048688 or 1-718-3541175 International dial in: +44-844-335-0351 Password/Conf ID: 921510 Live Webcast: http://www.shire.com/shireplc/en/investors OVERVIEW OF Q3 2010 FINANCIAL RESULTS 1. Product sales

For the three months to September 30, 2010 product sales increased by 32% to $794.3 million (2009: $602.5 million) and represented 91% of total revenues (2009: 90%).

Core Product Sales increased by 31% to $694.6 million (2009: $531.6 million), up 34% on a CER basis. Product Highlights

Exit Market Growth Share(1) Product Sales $M Sales CER US Rx(1) VYVANSE 151.2 +17% 1 +17% +28% 15% ELAPRASE 96.8 +7% 1 +11% n/a(2) n/a(2) REPLAGAL 92.1 +91% 1 +103% n/a(3) n/a(3) LIALDA / MEZAVANT 76.0 +16% 1 +17% +16% 19% PENTASA 57.1 +11% +11% -5% 15% VPRIV 49.5 n/a 1 n/a n/a(2) n/a(2) FOSRENOL 45.2 -5% 1 -1% -17% 7% INTUNIV 37.3 n/a 1 n/a n/a 3% FIRAZYR 2.9 +61% 1 +73% n/a(3) n/a(3) OTHER 86.5 -11% 1 -8% n/a n/a Core product sales 694.6 +31% 1 +34% ADDERALL XR 99.7 +41% 1 +40% +1% 7% Total product sales 794.3 +32% 1 +35%

(1) Data provided by IMS Health National Prescription Audit ("IMS NPA"). Exit market share represents the average monthly US market share in the month ended September 30, 2010.

(2) IMS NPA Data not available.

(3) Not sold in the US in Q3 2010.

VYVANSE - ADHD

The increase in VYVANSE product sales was princi
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SOURCE Shire plc
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