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Shire Proposes to Expand Specialist Gastrointestinal Portfolio
Date:8/3/2010

zation and/or development; government regulation of the Company's products; the Company's ability to manufacture its products in sufficient quantities to meet demand; the impact of competitive therapies on the Company's products; the Company's ability to register, maintain and enforce patents and other intellectual property rights relating to its products; the Company's ability to obtain and maintain government and other third-party reimbursement for its products; and other risks and uncertainties detailed from time to time in the Company's filings with the Securities and Exchange Commission.

DEUTSCHE BANK AG

Deutsche Bank AG is authorized under German Banking Law (competent authority: BaFin - Federal Financial Supervisory Authority) and authorized and subject to limited regulation by the FSA. Details about the extent of Deutsche Bank AG's authorization and regulation by the FSA are available on request.

    (i)   WGO Practice Guidelines - http://www.medscape.com/
    (ii)  Johanson Kralstein. Chronic constipation: a survey of the patient
          perspective. Aliment Pharmacol Ther 2007; 25:599-608
    (iii) Mertz H, Naliboff B, Mayer E. Physiology of refractory chronic
          constipation. Am J Gastroenterol 1999; 94:609-15.



    For further information please contact:

    Investor Relations:
    Eric Rojas, erojas@shire.com, +1-781-482-0999

    Media:
    Jessica Mann, 
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