Shire Delivers Strong Quarter: Driven by $243m of New Product Sales (+164% YOY Growth). Revenue Guidanc...(months to June 30 2008 (2007: $nil). Sel...)

administrative costs includes amortization and impairment charges of

intangible assets relating to intellectual property rights acquired

of $121.4 million for the three months to June 30, 2008 (2007: $17.6

million) and $152.3 million for the six months to June 30, 2008

(2007: $32.9 million).

(3) Costs, predominantly relating to manufacturing set-up costs for new

products, of $1.8 million and $3.6 million for the three months and

six months to June 30, 2007, have been reclassified from Research and

development to Cost of product sales.

Unaudited US GAAP results for the three months and six months to June 30,

2008

Consolidated Statements of Operations (continued)

3 months 3 months 6 months 6 months

to June to June to June to June

30, 30, 30, 30,

2008 2007 2008 2007

$M $M $M $M

________ ________ ________ ________

(Loss)/earnings per ordinary share -

basic (14.6c) (331.0c) 9.1c (317.5c)

________ ________ ________ ________

(Loss)/earnings per ordinary share - (14.6c) (331.0c) 8.2c (317.5c)

diluted

________ ________ ________ ________

(Loss)/earnings per ADS - diluted (43.8c) (993.0c) 24.6c (952.5c)

________ ________ ________ ________

Weighted average number of shares:

Basic 542.5 547.3 579.6 535.0

Diluted
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