Shire Delivers Strong Quarter: Driven by $243m of New Product Sales (+164% YOY Growth). Revenue Guidanc...(e Deputy Chairman. - On July 1 2008 G...)

- On July 1, 2008 Graham Hetherington joined Shire as Chief

Financial Officer and Executive Board Director. Graham Hetherington has

a broad range of experience in senior financial roles having most

recently held positions as Chief Financial Officer of Bacardi (2007)

and Allied Domecq plc (1999-2005).

- On April 24, 2008 Shire announced that Michael Rosenblatt

M.D. joined the Shire Board as a Non-Executive Director.

- On July 29, 2008 Robin Buchanan, due to his other

commitments, stepped down from the Shire Board on the completion of his

term of office.

Dividend

In respect of the six months ended June 30, 2008, the Board resolved to pay an interim dividend of 2.147 US cents per ordinary share (2007: 2.147 US cents per share).

Dividend payments will be made in Pounds Sterling to Ordinary shareholders and in US Dollars to holders of American Depository Shares ("ADSs"). A dividend of 1.085 pence per ordinary share (2007: 1.048 pence) and 6.441 US cents per ADS (2007: 6.441 US cents) will be paid on October 9, 2008 to persons whose names appear on the register of members of the Company at the close of business on September 12, 2008.

As previously disclosed Shire intends to put in place Income Access Share arrangements enabling shareholders to choose whether they receive their dividends from a company resident for tax purposes in the Republic of Ireland or from a company resident for tax purposes in the United Kingdom. The arrangements will be in place for the interim dividend. In accordance with the Shire ADS Deposit Agreement, the ADS Depositary will make an election on behalf of all holders of ADSs to receive UK sourced dividends. Details of the Income Access Share arrangements can be found in the Scheme Circular issued on April 16, 2008, which is available on the Company's website http://www.shire.com<
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