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Shire Delivers Excellent Growth for the Year, With the new Product Portfolio Achieving Sales of $1 Billion
Date:2/19/2009

_________ Total liabilities and shareholders' equity 3,933.7 4,330.1 _________ __________

Unaudited results for the three months and year to December 31, 2008 and 2007 Consolidated Statements of Operations

                                       3 months 3 months 12 months 12 months
                                             to       to        to        to
                                       December December  December  December
                                            31,      31,       31,       31,

                                           2008     2007      2008      2007

                                             $M       $M        $M        $M
    Continuing operations              ________ ________  ________  ________

    Revenues:

    Product sales                         704.3    661.3   2,754.2   2,170.2
    Royalties                              54.8     61.8     245.5     247.2
    Other revenues                          6.7      1.4      22.5      18.9
                                       ________ ________  ________  ________
    Total revenues                        765.8    724.5   3,022.2   2,436.3
                                       ________ ________  ________  ________

    Costs and expenses:

    Cost of product sales (1) (2)          90.6    101.0     408.0     320.3
    Research and development (1)          132.2    205.3     526.6     576.4
    Selling, general and administrative   339.2    331.3   1,422.9   1,178.8
     (1) (2)
    Integration costs                       2.8        -      10.3       1.3
    Gain on sale of product rights            -   (115.7)    (20.7)   (127.8)
    In-process R&D charge                   7.6   (29.6)     263.1   1,866.4
                                        ________ ________  ________  ________
    Total operating expenses              572.4 
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SOURCE  Shire Plc
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