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Shire Appoints Sylvie Gregoire President of Human Genetic Therapies Business
Date:9/24/2007

Seasoned leader brings added expertise to Shire management team

CAMBRIDGE, Mass., and BASINGSTOKE, England, Sept. 24 /PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, Nasdaq: SHPGY, TSX: SHQ), the global specialty biopharmaceutical company, announced today that Sylvie Gregoire has been appointed President of its Human Genetic Therapies (HGT) business, effective immediately. Sylvie brings more than 20 years of management, regulatory affairs, manufacturing and supply chain experience from biotechnology and pharmaceutical companies including Biogen Idec and Merck & Co. Sylvie replaces David Pendergast, former President of HGT, whose retirement was announced in March of this year. To ensure a smooth transition, David will continue with Shire through 2007 as an advisor.

In her role as President of Shire Human Genetic Therapies and a member of Shire's Management Committee, Sylvie is responsible for setting the strategic direction of the HGT business including managing the commercial and pipeline growth, directing the R&D and portfolio management processes, overseeing the supply teams, and also contributing to the execution of the overall strategic direction of Shire. She will report to Shire Chief Executive Officer, Matthew Emmens, and will be based at the Shire HGT headquarters in Cambridge, MA.

"Sylvie brings an impressive level of knowledge and expertise to Shire HGT, and her leadership will be key to the continued growth of our HGT business as well as to the global organization," said Matthew Emmens, Chief Executive Officer of Shire Pharmaceuticals. "We thank David Pendergast for his contribution towards the transformation of Shire HGT into a highly successful business and for creating an engine of future growth for Shire. We wish him an enjoyable and productive retirement."

Shire HGT has several projects in various stages of development, and over the past 18 months has received approval and launched ELAPRASE(TM) for the treatment of Hun
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SOURCE Shire plc
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