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Shire Announces Opening of Office in Japan
Date:2/20/2009

risks and uncertainties include, but are not limited to, risks associated with: the inherent uncertainty of research, development, approval, reimbursement, manufacturing and commercialization of the Company's Specialty Pharmaceutical and Human Genetic Therapies products, as well as the ability to secure and integrate new products for commercialization and/or development; government regulation of the Company's products; the Company's ability to manufacture its products in sufficient quantities to meet demand; the impact of competitive therapies on the Company's products; the Company's ability to register, maintain and enforce patents and other intellectual property rights relating to its products; the Company's ability to obtain and maintain government and other third-party reimbursement for its products; and other risks and uncertainties detailed from time to time in the Company's filings with the Securities and Exchange Commission.

    [1] IMS Health Incorporated

    For further information please contact:

    Investor Relations  Clea Rosenfeld (Rest of the World)  +44-1256-894-160
                        Eric Rojas (North America)          +1-484-595-8252
    Media               Matthew Cabrey (North America)      +1-484-595-8248
                        Jessica Cotrone (North America)     +1-617-613-4640




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SOURCE Shire Plc
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