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Shire Announces Opening of Office in Japan
Date:2/20/2009

ion of products in the Human Genetic Therapies pipeline, as well as identify potential future opportunities for growth in this market. He will also work closely with Japanese physicians and regulatory authorities to ensure the needs of affected patients and their families are being met.

Shire currently has numerous therapies available in Japan through strategic partnerships. In addition to the Japan representative office, Shire has offices in Singapore and Australia, and plans to continue exploring additional opportunities for growth throughout the Asia Pacific region.

Notes to Editors

SHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: http://www.shire.com.

"SAFE HARBOR" STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995

Statements included herein that are not historical facts are forward-looking statements. Such forward-looking statements involve a number of risks and uncertainties and are subject to change at any time. In the event such risks or uncertainties materialize, the Company's results could be materially adversely affected. The
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