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Shire Announces Holding of 81% in Jerini AG and Publication of Offer Document
Date:8/13/2008

rtain purchases of, or arrangements to purchase, Jerini Shares outside the United States, other than pursuant to the Offer, before or during the period in which the Offer remains open for acceptance. These purchases may occur either in the open market at prevailing prices or in private transactions at negotiated prices. As far as such purchases are agreed upon or already completed, they are reflected in the Offer Document; as far as such purchases will be undertaken or completed after the publication of the Offer Document, details of such purchases will be published pursuant to German WpUG requirements in the German Electronic Federal Gazette and at http://www.shire.com. Such publications of purchases undertaken or completed after the publication of the Offer Document will be made without undue delay, that is, in principle, within 48 hours after the transfer of shares has been effected or an agreement regarding the transfer of shares has been entered into.

Notes to editors

Shire Limited

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: http://www.shire.com.

"SAFE HARBOR" STATEMENT UNDER THE PRIVATE SE
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