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Shionogi-ViiV Healthcare Starts Phase III Trial for '572-Trii' Fixed-Dose Combination HIV Therapy
Date:2/3/2011

nt of the tolerability, long-term safety, and antiviral and immunologic activity of 572-Trii once-daily compared to EFV/TDF/FTC over 96 weeks.  Investigators will also evaluate viral resistance in patients experiencing virologic failure.

Together with the planned FDC bioequivalence study (ING114580) comparing the 572-Trii FDC tablet with '572 plus ABC/3TC, the SINGLE study is designed to support a regulatory filing for 572-Trii as a new fixed dose combination of '572/ABC/3TC.

About KIVEXA/EPZICOMKIVEXA/EPZICOM (abacavir/lamivudine) is a once-a-day HIV medication that combines abacavir sulfate and lamivudine in a single tablet and is indicated for the treatment of HIV-1 infection in adults.

Important Information about EPZICOM EPZICOM, in combination with other antiretroviral agents, is indicated for the treatment of HIV-1 infection in adults.EPZICOM is one of 3 medicines containing abacavir. Before starting EPZICOM, your healthcare professional will review your medical history in order to avoid the use of abacavir if you have experienced an allergic reaction to abacavir in the past.In one study, more patients had a severe hypersensitivity reaction in the abacavir once-daily group than in the abacavir twice-daily group.EPZICOM should not be used as part of a triple-nucleoside regimen.EPZICOM does not cure HIV infection/AIDS or prevent passing HIV to others.Important Safety InformationEPZICOM contains abacavir, which is also contained in ZIAGEN® (abacavir sulfate) and TRIZIVIR® (abacavir sulfate, lamivudine, and zidovudine). Patients taking EPZICOM may have a serious allergic reaction (hypersensitivity reaction) that can cause death. The risk of this allergic reaction is much higher if one has a gene variation called HLA-B*5701 than if one does not. Your doctor can determine with a blood test if you have this gene variation. If you get a symptom from 2 or more of the following groups while taking EPZICOM, call your doctor r
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SOURCE Shionogi-ViiV Healthcare, LLC
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