Navigation Links
Sheffield scientists shine a light on the detection of bacterial infection
Date:12/12/2011

Researchers at the University of Sheffield have developed polymers that fluoresce in the presence of bacteria, paving the way for the rapid detection and assessment of wound infection using ultra-violet light.

When contained in a gel and applied to a wound, the level of fluorescence detected will alert clinicians to the severity of infection. The polymers are irreversibly attached to fragments of antibiotics, which bind to either gram negative or gram positive bacteria both of which cause very serious infections informing clinicians as to whether to use antibiotics or not, and the most appropriate type of antibiotic treatment to prescribe. The team also found that they could use the same gels to remove the bacteria from infected wounds in tissue engineered human skin.

Speaking at the British Science Festival today (15 September), Professor Sheila MacNeil, an expert in tissue engineering and wound healing, explains: "The polymers incorporate a fluorescent dye and are engineered to recognise and attach to bacteria, collapsing around them as they do so. This change in polymer shape generates a fluorescent signal that we've been able to detect using a hand-held UV lamp."

"The availability of these gels would help clinicians and wound care nurses to make rapid, informed decisions about wound management, and help reduce the overuse of antibiotics," says project lead Dr Steve Rimmer.

Currently, determining significant levels of bacterial infection involves swabbing the wound and culturing the swabs in a specialist bacteriology laboratory with results taking several days to be available. The team is confident that its technology can ultimately reduce the detection of bacterial infection to within a few hours, or even less.

The research has already demonstrated that the polymer (PNIPAM), modified with an antibiotic (vancomycin) and containing a fluorescent dye (ethidium bromide), shows a clear fluorescent signal when
'/>"/>

Contact: Jo Kelly
jo@campuspr.co.uk
44-113-357-2100
University of Sheffield
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Sheffield scientists shine a light on the detection of bacterial infection
2. Sheffield Bio-Science Adds Chemically Defined Media Supplements to Product Portfolio
3. Singapore scientists lead human embryonic stem cell study
4. Scientists defuse the Vietnam time bomb
5. Scientists carve nanowires out of ultrananocrystalline diamond thin films
6. Berkeley Lab scientists develop new tool for the study of spatial patterns in living cells
7. Shaken, not stirred: Berkeley lab scientists spy molecular maneuvers
8. Using new technique, scientists uncover a delicate magnetic balance for superconductivity
9. Scientists create computing building blocks from bacteria and DNA
10. Scientists determine alternative insecticide dramatically reduces malaria transmission
11. Scientists take up golf to prove long-standing theory of cell stickiness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 20, 2014 The 6th Annual ... held on October 29-30 in San Francisco, CA. This ... and government researchers and clinicians focused on addressing and ... , In the twelve years since the sequencing of ... been introduced with pharmacogenetic information in the label and ...
(Date:8/20/2014)... Bulgaria (PRWEB) August 20, 2014 ... was released today including improvements to the enterprise ... and connectors for Lucene, SOLR and Elasticsearch. This ... for this high performance triplestore – GraphDB™ was ... interested in deploying the only mature enterprise resilient ...
(Date:8/19/2014)... Cellgen Diagnostics today ... fund a corporate lab for its genetic-based medical ... is a critical component in the move from ... implementation of personalized medicine – a more predictive, ... Indiegogo contributions will support Cellgen’s intent to develop ...
(Date:8/19/2014)... Md. , Aug. 19, 2014 CSSi, ... research industry, recently announced the formation of the company,s ... to announce the addition of Dr. William E. ... - http://photos.prnewswire.com/prnh/20140818/136957 The MCAB, ... a variety of therapeutic areas and set strategic goals ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3
... Car, VALLEY FORGE, Pa., Dec. 17 Good ... Diversified Racing Solutions,(DRS) to enter the NASCAR(R) Nationwide Series ... Sprint Cup Series in 2010. In the five-year,agreement, GNP ... the venture will be primarily funded by associate sponsor,relationships; ...
... Holding, Inc. (Other OTC: NHGI) today announced that ... are,posted on the OTCIQ, a service of the ... portal that provides issuers access to,innovative products and ... mitigate risk, gather market,intelligence, and inspire better corporate ...
... Maryland Stem Cell Research,Commission (Commission) today issued a ... under RFA-MD-07-3. The Commission is,soliciting nationwide applications from ... conduct basic and/or translational research on,all types of ... estimated that up to 16 fellowships will be ...
Cached Biology Technology:Good Neighbor Pharmacy Joins with Diversified Racing Solutions to Enter NASCAR Nationwide Series in 2008 2National Stem Cell Holding, Inc. Posts Company and Financial Information on the OTCIQ and Has Retained New CFO and Counsel to File Registration Statement With SEC 2Maryland Stem Cell Commission Issues Nationwide Request for Applications for New Post-Doctoral Fellowship Grants 2
(Date:8/20/2014)... Institutes of Health has awarded the Oklahoma Medical Research ... research on anthrax and the bacteria,s effects on humans. ... Ph.D., and his colleagues have studied the human immune ... Centers for Human Immunology. The original funding came soon ... the heels of the terrorist attacks of Sept. 11, ...
(Date:8/20/2014)... Biting into a chili pepper causes a burning spiciness ... Scientists exploring the chili pepper,s effect are using their ... kinds of pain, which can be caused by inflammation ... compound, which is being tested in clinical trials, in ... Tafesse and colleagues explain that decades ago, scientists had ...
(Date:8/20/2014)... therapy developed by researchers at the University of Missouri ... from a life-threatening heart condition caused by muscular dystrophy. ... Yi Lai, Ph.D., the leading author of the study ... Medicine,s Department of Molecular Microbiology and Immunology. "This is ... lead to a treatment for people with this devastating ...
Breaking Biology News(10 mins):$14.5 million grant awarded to continue anthrax studies 2Gene therapy protects mice from lethal heart condition, MU researchers find 2
... in the Journal of Trauma and Acute Care ... spinal cord-injured patients is successful not only in weaning ... to independent respiration, where they could breathe on their ... The stimulation is provided by the Diaphragm Pacing ...
... As the Endangered Species Act (ESA) celebrated its 40th anniversary at ... Wildlife Service (USFWS), was mired in controversy. At issue was a ... the List of Endangered and Threatened Wildlife and add the Mexican ... a result, the USFWS sought an independent peer review of the ...
... shape might be just as important in a biology lab ... role in the effectiveness of cells grown to repair or ... structures that enable cells to "shape up," researchers at the ... with a way to measure, and more importantly, classify, the ...
Cached Biology News:Diaphragm pacing in spinal cord injury successful in weaning patients from ventilators 2Diaphragm pacing in spinal cord injury successful in weaning patients from ventilators 3Panel issues report on gray wolf science 2Shape-sifting: NIST categorizes bio scaffolds by characteristic cell shapes 2
... CrysScreen is a software package that ... interface for custom buffer creation, set-up ... in crystallization trials. The software helps ... in automated protein crystallography: ...
The PROTEAN II slab gel casting stand is a component of the PROTEAN II XL and xi casting apparatus. It is supplied with gaskets....
Mouse monoclonal [H4B4] to LAMP2 - Lysosome Marker (Phycoerythrin) ( Abpromise for all tested applications). entrezGeneID: 3920 SwissProtID: P13473...
... Nikon's NIS-Elements revolutionizes imaging software ... automated intelligence to microscopes, cameras, components ... visualization and achiving tools. Its intuitive ... image acquisition times while providing powerful ...
Biology Products: