Navigation Links
Sheffield scientists shine a light on the detection of bacterial infection
Date:9/29/2011

Researchers at the University of Sheffield have developed polymers that fluoresce in the presence of bacteria, paving the way for the rapid detection and assessment of wound infection using ultra-violet light.

When contained in a gel and applied to a wound, the level of fluorescence detected will alert clinicians to the severity of infection. The polymers are irreversibly attached to fragments of antibiotics, which bind to either gram negative or gram positive bacteria both of which cause very serious infections informing clinicians as to whether to use antibiotics or not, and the most appropriate type of antibiotic treatment to prescribe. The team also found that they could use the same gels to remove the bacteria from infected wounds in tissue engineered human skin.

Speaking at the British Science Festival today (15 September), Professor Sheila MacNeil, an expert in tissue engineering and wound healing, explains: "The polymers incorporate a fluorescent dye and are engineered to recognise and attach to bacteria, collapsing around them as they do so. This change in polymer shape generates a fluorescent signal that we've been able to detect using a hand-held UV lamp."

"The availability of these gels would help clinicians and wound care nurses to make rapid, informed decisions about wound management, and help reduce the overuse of antibiotics," says project lead Dr Steve Rimmer.

Currently, determining significant levels of bacterial infection involves swabbing the wound and culturing the swabs in a specialist bacteriology laboratory with results taking several days to be available. The team is confident that its technology can ultimately reduce the detection of bacterial infection to within a few hours, or even less.

The research has already demonstrated that the polymer (PNIPAM), modified with an antibiotic (vancomycin) and containing a fluorescent dye (ethidium bromide), shows a clear fluorescent signal when
'/>"/>

Contact: Jo Kelly
jo@campuspr.co.uk
44-113-357-2100
University of Sheffield
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Sheffield Bio-Science Adds Chemically Defined Media Supplements to Product Portfolio
2. Scientists observe how superconducting nanowires lose resistance-free state
3. Controlling silicon evaporation allows scientists to boost graphene quality
4. Scientists utilize breath and sweat to detect trapped humans
5. Neuroscientists produce guide for ultrasound use to treat brain disorders in clinical emergencies
6. Scientists create mammalian cells with single chromosome set
7. Scripps research scientists find clue to cause of childhood hydrocephalus
8. Leicester scientists deploy space-age technologies at science-fiction style sick bay
9. Scientists develop new technologies for understanding bacterial infections
10. Syngene Expands Ongoing Relationship with CAS to Provide SciFinder® to All Its Scientists
11. A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... October 18, 2014 The Biomass ... in the five years to 2014. The industry's expansion ... energy tax credits that encouraged the use of biomass ... portfolio standards (RPSs), which require local utilities to generate ... total energy portfolio. Increased campaigning for green technology also ...
(Date:10/18/2014)... The report " Cloud Analytics Market ... Speech; Machine; Video; Predictive Analytics: Global Advancements, Delivery ... Analysis (2013 - 2018) ", defines and segments ... segments with an in-depth analysis and forecasting of ... driving this market, various restraints, and opportunities impacting ...
(Date:10/17/2014)... have received a $451,781 Air Force Office of Scientific ... micro- and nano-scale level that will provide clues for ... Mechanical and Aerospace Engineering, said the new technology and ... X-rays of an aircraft,s wing., "We,ll be able to ... look at it on this scale," Huang said. "Certain ...
(Date:10/17/2014)... and HILDEN, Germany ...   , Translational research in cancer ... being presented at the American Society of Human ... 250,000-plus DNA samples linked to Ingenuity ®  Knowledge ... for genomic analysis  Ingenuity ®  Variant ...
Breaking Biology Technology:Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5UT Arlington project to detect possible damages in aircraft parts early in process 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 3QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 4QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 5QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 6
... May 24, 2010 Simbionix USA Corporation,the world,s leading provider of ... is launching,two new hands-on training systems- the Lap Nepherctomy simulation module and,the ... AUA annual meeting in San Francisco next week. , ... The Lap ...
... BEIJING , May 24 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (Nasdaq: ... Weidong Yin ,Chairman, President & CEO, will present at the 2010 UBS Global ... London,England . Sinovac,s presentation is scheduled for Wednesday, June 2, 2010 ... , , ...
... ... ... plans to add to its natural color capabilities by investing $16 million at its Color ... facility dedicated wholly to natural colors production. The plant will be the largest and most ...
Cached Biology Technology:Simbionix to Reveal Two new Products at the Upcoming American Urology Association (AUA) Annual Meeting 2Simbionix to Reveal Two new Products at the Upcoming American Urology Association (AUA) Annual Meeting 3Sinovac to Present at 2010 UBS Global Specialty Pharmaceuticals Conference 2Sensient Technologies Corporation Announces Major Investment in Natural Colors 2
(Date:10/14/2014)... 2014)—It,s been millions of years since T. rex ... by Ohio University scientists is breathing life back into ... dinosaur snouts. The research has important implications for how ... to enhance the sense of smell and cool their ... Ohio University doctoral student Jason Bourke, lead author of ...
(Date:10/14/2014)... High doses of fish oil supplements, rich in omega-3 fatty ... irregular heartbeat in which the heart can beat as fast ... trial led by the Montreal Heart Institute were published in ... on October 7th. , For the trial, 337 patients with ... to 4 grams of fish oil a day or to ...
(Date:10/14/2014)... takes between 10 and 20 years to develop, ... of intervention if detected early, which may be ... Australian clinical researchers. , Dr Jeremy Humphris ... of Medical Research, analysed medical histories and tumour ... cancer patients, operated on between 1994 and 20122. ...
Breaking Biology News(10 mins):Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Early detection window when pancreatic cancer is in the family 2
... continues to shed its reputation as DNA's faithful sidekick. Now, ... have found that a class of small RNAs called microRNAs ... research had indicated. , "MicroRNAs are affecting the majority of ... level," says Andrew Grimson, a post-doctoral fellow in Bartel's lab. ...
... and insight to a looming pandemic , If health ... may bring with it one of the most sweeping, ... ever seen. , While that prospect would terrify the ... candidate at Lehigh University, who has been researching the ...
... story about the discovery , After reviewing ... an independent team of ornithologists has confirmed the existence ... data provided to them in the last few days ... at Yale, the University of Kansas, and Florida Gulf ...
Cached Biology News:MicroRNAs have shaped the evolution of the majority of mammalian genes 2MicroRNAs have shaped the evolution of the majority of mammalian genes 3Researcher says flu responders can learn from 1918 epidemic 2Researcher says flu responders can learn from 1918 epidemic 3Researcher says flu responders can learn from 1918 epidemic 4Independent researchers confirm the existence of ivory-billed woodpecker 2
... using PULSin may be superior to transfection ... traditional transfection, with PULSin you can study ... time course of proteins in cells. Likewise, ... information than traditional RNA interference experiments. ...
... an automated instrument with a thin silicon ... using light or fluorescence microscopy. Biaxial strain ... fibroblast cells can be simulated by mechanical ... Y axis of our strain chamber. Strain ...
... The versatile ST-195 allows real-time observations ... conditions. This instrument has 64 different strain ... CO2 incubator. The thin silicon strain chamber ... inverted microscopes and fluorescence microscopy. ST-195 can ...
Immunogen GST fusion protein corresponding to full-length rat JNK3/ SAPK1b. Quality Assurance Routinely evaluated by immunoblot. Stability 2 years at -20°C from date of shipment GenBank A...
Biology Products: