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Seven Abstracts Featuring Exelixis Compounds Accepted for Presentation at 2008 ASCO Annual Meeting

Two oral presentations, two poster discussion presentations, three poster


SOUTH SAN FRANCISCO, Calif., March 31 /PRNewswire-FirstCall/ -- Exelixis, Inc. (Nasdaq: EXEL) announced today that data from clinical trials of the company's investigational compounds XL647, XL184, XL765 and XL880 will be presented at the 2008 American Society of Clinical Oncology (ASCO) Annual Meeting, which will be held from May 30 to June 3, 2008 in Chicago, Illinois. The clinical trial data will be described in two oral presentations (XL184 and XL765), two poster presentations and discussions (XL647), and three poster presentations (XL647 and XL880).

Oral Presentations

-- XL184 (RET, MET, VEGFR2). Data from a phase 1 trial of XL184 in

patients with advanced malignancies, including medullary thyroid

cancer, will be presented on Sunday, June 1, 2008, starting at 10 a.m.

local time (Abstract #3522).

-- XL765 (PI3K, mTOR). Data from a phase 1 trial of XL765 in patients

with advanced solid tumors will be presented on Saturday, May 31,

2008, starting at 1:15 p.m. local time (Abstract #3510).

Poster Presentations and Discussions

-- XL647 (EGFR, HER2, VEGFR2). Data from a phase 2 trial of XL647 in

NSCLC patients with acquired resistance to EGFR tyrosine kinase

inhibitors will be presented on Monday, June 2, 2008, during the 8

a.m.-noon session (Abstract #8028).

-- XL647 (EGFR, HER2, VEGFR2). Data from a phase 1 trial of XL647 dosed

daily in patients with advanced solid malignancies will be presented

on Saturday, May 31, 2008, during the 8 a.m.-noon session (Abstract


Poster Presentations

-- XL647 (EGFR, HER2, VEGFR2). Data from a phase 2 trial of XL647 in

clinically selected NSCLC patients enriched for the presence of EGFR

mutations will be presented on Sunday, June 1, 2008, during the 2-6

p.m. session (Abstract #8053).

-- XL880* (MET, VEGFR2). Data from a phase 2 trial of XL880 in patients

with papillary renal cell carcinoma will be presented on Saturday, May

31, 2008, during the 8 a.m.-noon session (Abstract #5103).

-- XL880* (MET, VEGFR2). Data from a phase 2 trial of XL880 in MET

amplified, poorly differentiated gastric cancer will be presented on

Monday, June 2, 2008, during the 8 a.m.-2 p.m. session (Abstract


* XL880 was selected by GlaxoSmithKline in December 2007 for further

development and commercialization.

About Exelixis

Exelixis, Inc. is a development-stage biotechnology company dedicated to the discovery and development of novel small molecule therapeutics for the treatment of cancer and other serious diseases. The company is leveraging its fully integrated drug discovery platform to fuel the growth of its development pipeline, which is primarily focused on cancer. Currently, Exelixis' broad product pipeline includes investigational compounds in phase 2 and phase 1 clinical development. Exelixis has established strategic corporate alliances with major pharmaceutical and biotechnology companies, including GlaxoSmithKline, Bristol-Myers Squibb Company, Genentech, Wyeth Pharmaceuticals and Daiichi-Sankyo. For more information, please visit the company's web site at

Exelixis and the Exelixis logo are registered U.S. trademarks.

SOURCE Exelixis, Inc.
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