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Sequella Receives SBIR Funding Grant from the NIH for Further Development of Tuberculosis Drug SQ609
Date:2/17/2009

ROCKVILLE, Md., Feb. 17 /PRNewswire/ -- Sequella, Inc., a clinical-stage biopharmaceutical company focused on diseases of epidemic potential, today announced the receipt of a Small Business Innovation Research (SBIR) Phase I Grant from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), to fund further preclinical development of the company's novel tuberculosis (TB) lead dipiperidine drug compound, SQ609.

The SBIR grant will enable Sequella to perform IND-directed preclinical in vitro and in vivo potency, pharmacology, and toxicity studies of SQ609, both as a single agent and in combination with other more established therapies.

"We are grateful that the grant reviewers recognized the potential of this new antibiotic class, and its lead representative drug compound SQ609, and we appreciate NIAID support of these important preclinical studies with SBIR funding," said Dr. Carol Nacy, CEO of Sequella. "The SBIR grant program at the NIH serves a vital role in assisting companies to develop new antibiotics for important infectious diseases that impact U.S. public health."

About SQ609 and TB

SQ609 is a novel small molecule dipiperidine antibiotic selected from a proprietary chemical library of over 250,000 new molecular entities with activity for a broad spectrum of infectious diseases. Orally bioavailable with excellent single-drug activity against Mycobacterium tuberculosis in vitro and in vivo, SQ609 has demonstrated synergistic activity with several front-line antitubercular drugs and can be readily synthesized on a large scale.

Tuberculosis (TB) is the cause of the largest number of human deaths attributable to a single etiologic agent and the leading cause of death in those who are HIV-positive, accounting for 11% of the AIDS-related deaths worldwide. If one includes TB deaths in the HIV-c
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SOURCE Sequella, Inc.
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