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SentoClone International AB Significantly Strengthens its Global Patent Portfolio Covering its Clinical Stage Sentinel Node-derived CD4 T-cell Cancer Therapy
Date:6/5/2013

STOCKHOLM, June 5, 2013 /PRNewswire/ --

New patents granted in Japan, the USA and Europe

SentoClone International AB announced today that it has been granted additional patents in Japan, the US and Europe further reinforcing the global protection of its proprietary SentoClone® technology, an active patient specific cellular immunotherapy against cancer based on the ex vivo cultivation and activation of CD4+ T-cells. The technology has advanced to Phase II clinical trials following Phase I and pilot studies in patients with colorectal and bladder cancer.

SentoClone International´s chairman Pingsheng Hu said, "We are determined to develop our SentoClone® technology as rapidly as possible so that it can become an effective patient specific cancer therapy without significant side effects for the broad range of cancer patients worldwide. The recent patents we have been granted in Japan, the US and Europe means we have very solid IP in all major markets in the field of sentinel node derived T-cells in cancer therapy. We believe this much stronger patent protection will allow us to attract development partners so that we can make this novel approach to cancer therapy available to the many patients globally who could benefit."

The SentoClone® technology builds on a unique approach whereby CD4+ T- helper cells, highly specific for the patient's individual tumor, are extracted from the tumor's draining lymph node (the sentinel node) and cultivated ex vivo in a GMP production facility before being returned to the patient via one single infusion. During cultivation, the T-cells are stimulated with growth factors and re-activated with antigen from the patient's individual tumor. Once ret
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