Navigation Links
Sensitivity Enhancements to Monogram's Trofile(TM) Assay Demonstrate Improved Power to Select Patients for CCR5 Antagonist Therapy
Date:6/16/2008

SOUTH SAN FRANCISCO, Calif., June 16 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc. (Nasdaq: MGRM) today announced that data related to the enhanced performance of the company's HIV tropism assay were presented in an oral presentation at the 17th International HIV Drug Resistance Workshop in Sitges, Spain. Trofile was introduced commercially upon FDA approval of Selzentry(TM) (maraviroc), Pfizer's first in class CCR5 antagonist, in August 2007. Recent enhancements to Monogram's Trofile(TM) HIV co-receptor tropism assay have made it substantially more sensitive at identifying minor subpopulations of CXCR4-using virus (X4 or dual/mixed (D/M) tropic) that may portend treatment failure with CCR5 antagonists. The Trofile assay is now capable of detecting CXCR4 tropic virus existing at levels as low as, or in some cases lower than, 0.3% of the total virus population. At levels of X4 using virus as low as 0.3%, Trofile is 100% sensitive.

"The CCR5 antagonist class of drugs has become an important addition to the choice of therapies for treatment of HIV," said Eric Daar, M.D., Chief of HIV Medicine at Harbor-UCLA Medical Center. "Selecting the right patients is critical, not just for the appropriate use of CCR5 antagonists but also to protect the other drugs in the patient's regimen from unnecessary exposure to the development of resistance. The availability of Trofile with enhanced sensitivity now provides further confidence for physicians that treatment choices can be properly assessed."

In an oral presentation during the session on "New Resistance Technologies and Interpretations," Monogram scientist Dr. Jacqueline Reeves presented an analysis of subjects from the AIDS Clinical Trials Group 5211 (ACTG 5211) study. ACTG 5211
'/>"/>

SOURCE Monogram Biosciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Agendia Acquires Rights to the Discovery of a Major Drug Resistance Mechanism in Breast Cancer Potentially Leading to a Herceptin(R) Sensitivity Test
2. ANX-514 Reduces Hypersensitivity Reactions Without Impacting Pharmacokinetics or Antitumor Activity in Preclinical Tests
3. Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity
4. New Dual Cold Probe From Varian, Inc. Increases Sensitivity and Reduces Analysis Times for 13C NMR Experiments
5. Olympus FluoroPoint(TM) System Provides High-Sensitivity Single Molecule and Protein Interaction Analysis for Screening and Research
6. Study Reaffirms Superiority of Trofile(TM) Assay
7. New York Medicaid Program Establishes Coverage for Trofile(TM)
8. Caliper Life Sciences Introduces High Throughput RNA Assay to Improve Workflow in Gene Expression Studies
9. ProImmune Launches New MHC-Peptide Binding Assay for Class II HLA Alleles
10. Assay Designs(TM) Announces Additions to the Leadership Team
11. MedAssets Supply Chain Systems Selects Siemens Medical Solutions Diagnostics for Chemistry, Automation and Immunoassay Solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 2014 Barnhardt Manufacturing Company ... its Organic Cotton . The USDA Certified Biobased ... biobased ingredients meets or exceeds levels set by USDA. ... whole or in significant part of agricultural, forestry, or ... Organic cotton to be immediately identified as a USDA ...
(Date:9/19/2014)... -- Dublin ... the addition of the  "Micro Market Monitor : ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ,The ... segments in the chromatography market. The market was ... to reach $2.0 billion by 2019, at a ...
(Date:9/19/2014)... , September 19, 2014 The new ... Spain , available today on PharmaBoardroom.com for ... Eurozone crisis that rocked the Spanish economy in 2009, and ... pharma community has remained pragmatic in times of trouble. ... still the fifth biggest European market, and the general conditions ...
(Date:9/18/2014)... 2014 HealthTronics, Inc ., ... radiology products and services, announced that a poster ... cryoablation) versus external beam radiotherapy (EBRT) is being ... Urological Association (MAAUA) Annual Meeting in Baltimore, Maryland ... of Cryosurgery and External Beam Radiation as Treatments ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2
... Delivers Precision Illumination Advances , ... Ann Arbor, MI (PRWEB) December 10, ... for added precision, flexibility and comfort in engineering, assembly, laboratory and inspection ... Inc. of Ann Arbor, Mich., uses a ring of 60 lights ...
... could be sustained for many years to come thanks ... Laboratory (NPL) that is applying advanced techniques to magnetic ... transistors on an integrated circuit doubles every two years. ... experts believed that when the characteristic transistor size reduces ...
... Inc. (Nasdaq: EVVV ),a global endovascular ... clearance from the U.S. Food & Drug Administration ... peripheral angioplasty balloon,catheters. ev3 expects to begin ... catheters globally in January 2009. , ...
Cached Biology Technology:60 LED Lights Enhance Magnifying Lamp for Assembly, Engineering, Inspection or Research 260 LED Lights Enhance Magnifying Lamp for Assembly, Engineering, Inspection or Research 3ev3 Inc. Receives FDA Clearance to Market EverCross and NanoCross Peripheral Angioplasty Balloons 2ev3 Inc. Receives FDA Clearance to Market EverCross and NanoCross Peripheral Angioplasty Balloons 3
(Date:9/18/2014)... are too stressed they are often grouchy, grumpy, nasty, ... (BMI) at EPFL have just highlighted a fundamental synaptic ... the loss of social skills and cognitive impairment. When ... molecule in the brain. This was revealed by a ... Carmen Sandi,s team went to look for answers in ...
(Date:9/18/2014)... the protective tentacles of host anemones, but new research ... kilometres across the open ocean. Although the process of ... is the first time that the high level exchange ... Dr Steve Simpson, Senior Lecturer in Marine Biology and ... from the Australian Research Council Centre of Excellence for ...
(Date:9/17/2014)... doctoral student have designed a device based on a ... and dew., The device could provide water in drought-stricken ... Cheng Luo, professor in the Mechanical & Aerospace Engineering ... College of Engineering department, published "Bioinspired Plate-Based Fog Collectors" ... Society) Applied Materials & Interfaces ...
Breaking Biology News(10 mins):How stress tears us apart 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3Shorebird's beak inspires UT Arlington research on water collection 2
... Fla., May 23, 2012  One size does not fit all ... U.S. consumer. According to a recent HealthFocus® International study on ... weight they need to lose, but also in their motivations ... losing weight.    "New approaches to combatting obesity ...
... N.C. -- A Duke University-led study of North Carolina ... may be higher in nonwhite toddlers than in white ... exposure to the chemicals is higher among toddlers whose ... measure of lower socioeconomic background. Hand-to-mouth activity ...
... multiple segments was an exclusive feature of land-dwelling animals. But ... eel suggests that this complex anatomy arose separately from ... land. Tarrasius problematicus was an eel-like fish ... now Scotland, in the Carboniferous period between 359 million and ...
Cached Biology News:New HealthFocus® International Study Reveals Five Very Different Weight Management Consumers 2Socioeconomics may affect toddlers' exposure to flame retardants 2Socioeconomics may affect toddlers' exposure to flame retardants 3Human-like spine morphology found in aquatic eel fossil 2Human-like spine morphology found in aquatic eel fossil 3
...
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
Full-length cDNA clone CS0DJ013YG01 of T cells (Jurkat cell line) of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86SZ3] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: