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Senex Biotechnology Announces Presentation of Alzheimer's Disease Drug Discovery Effort
Date:10/15/2007

NEW YORK, Oct. 15 /PRNewswire/ -- Senex Biotechnology, Inc. presented today new results from its drug discovery program at the 8th International Conference on Alzheimer's Disease Drug Discovery in New York. Dr. Igor Roninson, the President of Senex, described the identification of the first drug candidates that block aging cells from producing excessive amounts of several proteins involved in Alzheimer's disease, including: amyloid precursor protein (APP); BACE1 that converts APP to beta-amyloid; and tissue transglutaminase (TGM2) that cross-links beta-amyloid to form amyloid plaques. Excessive accumulation of beta amyloid and amyloid plaques is believed to cause the symptoms of Alzheimer's disease. The signaling pathway targeted by Senex compounds was also implicated in cancer and some other diseases of old age, providing additional disease targets for drug development.

Because of their unique mechanism of action, Senex drug candidates only inhibit aging-associated increases in Alzheimer's disease-associated proteins, and therefore, may be better tolerated than drug candidates that reduce APP and APP-converting enzyme activities below normal levels.

In a study first reported by Dr. Roninson in 2000 and awarded the first annual Life Extension Prize, human cells that cease dividing were discovered to increase the production of many proteins that promote the development of Alzheimer's disease, cancer and several other diseases associated with old age. Senex scientists have developed and applied a proprietary high-throughput screening assay for compounds that prevent the induction of such proteins in non-dividing cells. The lead class of active compounds identified by Senex inhibits the induction of disease-associated genes and changes the typical "aged" (senescent) appearance of cells that cease dividing. These compounds also increase the activity of tumor-suppressor proteins that prevent the development of cancers. Senex is planning to develop its
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SOURCE Senex Biotechnology, Inc.
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