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Senetek Affirms Strong Financial Position
Date:10/13/2008

facing and bruising from injectable fillers with clinical trials being scheduled to confirm these findings. Senetek remains confident that Pyratine-6(TM) revenues will reach a $10.8 Million annual run rate by December 2009 as previously forecasted. By first establishing brand credibility with key influencers, Senetek's growing sales team will have the tools needed to quickly and effectively achieve sales goals.

"Despite current world economic uncertainty, Senetek is in a secure and strong position to execute on its sales, marketing and development strategy," says Mr. Massino. "Senetek's strength will continue to be the development and commercialization of patentable products with treatment advantages."

About Senetek, PLC

Senetek PLC (OTCBB: SNKTY) is a life sciences company engaged in the development of technologies that target the science of healthy aging. The company's extensive research collaborations have resulted in a strong pipeline of patented compounds and products with broad therapeutic applications and a leading presence in dermatology. Senetek collaborates with established specialty pharmaceutical companies in the final development and marketing of its proprietary products, most recently resulting in the development of the best-selling anti-aging product sold in the North American physician market. For more information, visit the company's website at http://www.senetekplc.com.

This news release contains statements that may be considered 'forward- looking statements' within the meaning of the Private Securities Litigation Reform Act. Forward-looking statements by their nature involve substantial uncertainty, and actual results may differ materially from those that might be suggested by such statements. Important factors identified by the Company that it believes could result in such material differences are described in the Company's Annual Report on Form 10-K for the year 20
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