Navigation Links
SemBioSys updates Apo AI development program
Date:8/22/2007

come available," said Andrew Baum, President and CEO of SemBioSys Genetics Inc. "In the meantime, we will continue to scale-up the successful Apo AI Milano seed lines to allow us to initiate animal trials with this material as soon as possible."

SemBioSys expects to receive in vivo efficacy results from animal trials for Apo AI produced in its model plant system, Arabidopsis, before the end of 2007. The Company is currently scaling up safflower-produced Apo AI Milano in order to initiate preclinical animal trials as soon as sufficient material is available.

The Company currently intends to partner one, or both, of the native Apo AI and Apo AI Milano programs prior to or shortly after Phase I clinical trials in 2009. SemBioSys believes its proprietary oilbody-oleosin production system offers the potential to overcome the manufacturing cost and capacity challenges of traditional fermentation-based technologies that have impeded the commercial development of Apo AI.

About Apo AI

Apo AI is a developmental-stage cardiovascular therapy, designed to rapidly stabilize and diminish atherosclerotic plaque for the prevention and treatment of cardiovascular disease. Apo AI is the major apolipoprotein associated with HDL, commonly referred to as "good cholesterol", which naturally removes plaque from arteries. Apo AI Milano is a natural variant of native human Apo AI characterized by a single amino acid substitution in its primary structure. In an epidemiological study, Apo AI Milano appears to confer enhanced resistance to atherosclerosis, suggesting that it may offer clinical advantages in the treatment of cardiovascular disease.

In a six week clinical trial, Esperion Therapeutics (acquired by Pfizer in 2003) demonstrated that its Apo AI Milano variant/phospholipid formulation could reduce plaque volume at a level and speed of atherosclerotic regression unattainable with any current drug therapy. Similarly, both CSL Limited and Borean Pharma A/S h
'/>"/>

SOURCE SemBioSys Genetics Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Merge announces sofware updates, upcoming acquisition
2. Tech Digest: Merge eMed product updates; Renaissance Learning 3rd qtr results
3. Solinus updates MailFoundry anti-spam hardware, switching to Linux
4. Wingra Technologies updates data migration software
5. The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis
6. Rapid Method Development With the BioLogic DuoFlow Chromatography System for the Purification of His-Tagged Proteins
7. A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis
8. Development of a Multiplex Bead-Based Assay for Antibody Screening of a Nonhuman Primate Colony on the Bio-Plex System
9. The development of a CXCR2 chemokine receptorbinding assay using the LEADseeker Multimodality Imaging System
10. The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System
11. The development of a melanocortin MC5 receptor binding assay using the LEADseeker Multimodality Imaging System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... have made great strides in saving China,s endangered national ... over 65 giant panda reserves that have been established ... just 1596 pandas remain in the wild. , ... save the panda by improving genetic diversity, avoid inbreeding ... how are these high-profile programs doing so far? , ...
(Date:7/23/2014)... LOS ANGELES , July 23, 2014 /PRNewswire-iReach/ -- ... enhance cognitive performance for the long term. They are ... competitive edge of sustained energy as an alternative to ... launch Think Drinks on Indiegogo on July 29, 2014, ... the 30-day campaign. Photo - http://photos.prnewswire.com/prnh/20140723/129697 ...
(Date:7/23/2014)... Last year, Formedix celebrated ... global provider of data management solutions for clinical trials. ... system for electronic data capture (EDC) and clinical data ... study execution tools added TrialMaster to its Transform for ... of Transform for TrialMaster, is being released this week, ...
(Date:7/23/2014)... StemGenex® , the leading resource for ... at improving the lives of patients dealing with degenerative ... disease. StemGenex believes that a commitment to the ... when providing care to patients with degenerative diseases. ... accessible to the millions of individuals currently living with ...
Breaking Biology Technology:truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 3
... 15 /PRNewswire-Asia-FirstCall/ -- American Oriental,Bioengineering, Inc. (NYSE: AOB ), ("the Company" or "AOBO"), ... prescription and over the counter ("OTC"),products, today announced financial results for the fourth quarter and fiscal,year ... ... ...
... ... and material testing, is taking strides to expand their Product and Material Testing Division by ... ... device package, product and material testing, is taking strides to expand their Product and Material ...
... that it has received a US Patent Office Notice of Allowance of patent claims which strongly protects the formation of cartilage by the unique NELL ... ... , , ... ...
Cached Biology Technology:American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 2American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 3American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 4American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 5American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 6American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 7American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 8American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 9American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 10American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 11American Oriental Bioengineering Reports Fourth Quarter and Full Year 2009 Financial Results 12DDL Expands the Product & Material Testing Division 2DDL Expands the Product & Material Testing Division 3Bone Biologics Announces a Major US Patent Issuance For Its Recombinant Protein Process For the Formation of Cartilage 2Bone Biologics Announces a Major US Patent Issuance For Its Recombinant Protein Process For the Formation of Cartilage 3
(Date:7/24/2014)... has different effects on different species of fish, ... of Bristol and Exeter which tested fish anti-predator ... a flying seagull predator model when exposed to ... European minnows. , Lead author Dr Irene ... "Noise levels in many aquatic environments have increased ...
(Date:7/24/2014)... sake brewery has its own microbial terroir, meaning the ... those found in the product, creating the final flavor ... journal Applied and Environmental Microbiology . This is ... of a sake brewery. , Many sake makers ... David A. Mills of the University of California, Davis, ...
(Date:7/24/2014)... this week for an all-day public forum on a ... (EPA) to dredge toxic sediment from an eight-mile stretch ... called the plan, which proposes removing 4.3 million cubic ... riverbed, one of the largest cleanups in the agency,s ... off-site. , "We need to ensure the future well-being ...
Breaking Biology News(10 mins):The microbes make the sake brewery 2Experts Weigh the Pros and Cons of a $1.7 Billion EPA Cleanup Plan for the Passaic River at an NJIT 2
... mandate communitywide water conservation measures, individualsparticularly homeownerscan make ... Hoping to provide urban planners with more information ... supplies, a team from New Mexico State University ... toward high desert plants. Rolston St. Hilaire, Dawn ...
... The Federation of American Societies for Experimental Biology (FASEB) ... the travel award recipients for the 2010 Society for ... Annual Meeting in Anaheim, California from September 30 ... promote the entry of underrepresented minority students, postdoctorates and ...
... Bethesda, MD FASEB MARC (Minority Access to Research ... the 2010 Societ Italiana di Patologia (SIP) XXX National ... These awards are meant to promote the entry of ... of the basic science community and to encourage the ...
Cached Biology News:Santa Fe homeowners weigh in on landscape preferences 2MARC Travel Awards announced for the 2010 SACNAS Annual Meeting 2
Collected from animals of U.S. origin.Collected from animals of U.S. origin. *Can be used in cell growth studies and immunoassays. *Sterility tested, * Mycoplasma tested upon request, *Endoto...
Fetal Calf Serum Replacement (Bistec) serum...
... reagent for Virus isolation ... unique water insoluble Elastomeric ... and chaotropes; Engineered to ... viruses while preserving infectivity; ...
Non-Receptor Tyrosine Kinase Sampler Kit 10 mu g each...
Biology Products: