Navigation Links
SemBioSys Demonstrates Functionality of its Safflower Produced Apo AI(Milano)
Date:6/5/2008

Company Achieves Important Milestone in Development of Next Generation

Cardiovascular Drug

CALGARY, June 5 /PRNewswire-FirstCall/ - SemBioSys Genetics Inc. (TSX:SBS), a biotechnology company dedicated to developing a portfolio of therapeutic proteins for metabolic and cardiovascular diseases, today announced that it has demonstrated that its safflower-produced Apo AI(Milano) (safflower Apo AI(Milano)) is functional in a widely accepted animal model. Working with the laboratory of Dr. Jean Claude Tardif at the Montreal Heart Institute (MHI), the company demonstrated that safflower Apo AI(Milano) increased cholesterol mobilization substantially in mice which, in conjunction with analytical and in vitro assays, indicates that safflower Apo AI(Milano) is physiologically and pharmaceutically comparable to microbially-produced Apo AI. In human trials, microbially-produced Apo AI(Milano) has been demonstrated to remove plaque from arteries (plaque regression), and holds potential for addressing one of the greatest unmet medical needs today - the reversal of atherosclerosis.

Dr. Maurice Moloney, founder and chief scientific officer of SemBioSys commented, "Scientists at SemBioSys and our academic collaborators have conducted extensive work on safflower Apo AI(Milano) and have established that safflower Apo AI(Milano) is comparable to Apo AI derived from other sources, as described in the literature. Its identity and functionality was confirmed through use of mass spectrometry, and lipid clearance, cellular cholesterol efflux and whole-animal cholesterol mobilization assays."

Dr. Jean-Claude Tardif, director of the Montreal Heart Institute Research Centre, who is a world leader in the study of HDLs and the physiological role of Apo AI noted, "Apo AI and Apo AI(Milano) hold the potential to be a useful therapy for the treatment of cardiovascular disease through the unique mechanism of plaque regression. Our research at
'/>"/>

SOURCE SemBioSys Genetics Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. SemBioSys to present at the Needham & Company Biotechnology and Medical Technology Conference
2. SemBioSys provides update on shrimp feed additive, Immunosphere(TM)
3. SemBioSys announces first quarter 2008 financial and operational results
4. SemBioSys receives milestone payments from AVAC Ltd.
5. SemBioSys initiates toxicology study for safflower-produced insulin
6. SemBioSys announces 2007 financial and operational results
7. SemBioSys GLA Partner Enters Strategic Alliance for the Sales and Marketing of GLA-Rich Safflower Oil
8. SemBioSys awarded key patent for the production of oleosome emulsions by the European Patent Office
9. SemBioSys to present at the 10th Annual BIO CEO & Investor Conference
10. SemBioSys signs option agreement for safflower-produced food ingredient
11. SemBioSys announces 2007 third quarter results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... 2014 As pet owners drew up their lists of New ... "Take better care of my furry companion." Nowadays there are pet ... carrying cases to take the little canine or feline darlings along ... to buy some pricey toys at the pet store. But anyone ...
(Date:1/14/2014)... MA (PRWEB) January 14, 2014 iLab Solutions, ... Detwiler as the new Director of Product Strategy. In this ... well as iLab sub-teams to guide in the development of ... iLab provides the maximum possible benefit to the scientific community ...
(Date:1/14/2014)... Ontario , Jan. 14, 2014   Kinaxis ®, provider ... SCM ) and sales and operations planning ( S&OP ) ... Biomanufacturing Summit , which will be held at the ... the conference, join Kinaxis customer Elisabeth Kaszas , Director ...
(Date:1/14/2014)... Independent publisher Bitingduck Press, with offices in Altadena ... ideas for 2014 in production and sales of interactive ... high-quality, low-cost, DRM-free ebooks and to use the sales ... first major development will be bookstore sales in local ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... - At least 45 girls in grades six ... Tech 2007, which will be held June 26 to ... ,The program, sponsored by area technology employers to encourage ... technology, will feature hands-on technical activities that introduce girls ...
... has been removed for Bruce Mass following his appointment ... Wisconsin-Milwaukee . , ,Rita Hartung Cheng, provost and vice ... national search. , ,Maas has undergraduate majors in accounting ... as campus budget manager, assistant dean for business affairs ...
... of Fresno in California's San Joaquin Valley is one of ... from grapes to livestock, from almonds to dairy products, and ... San Joaquin Valley these days is biofuel. , ,Like many ... recent visit are happy that demand for ethanol and biodiesel ...
Cached Biology Technology:Kind approach to leveraging biofuels 2Kind approach to leveraging biofuels 3
(Date:7/10/2014)... everyday household items such as washing machines could hold ... new study has claimed., As part of an EPSRC ... including those from the University of Exeter, have shown ... replicated in the natural world to help restock declining ... in essence a built-in feedback control mechanism to maintain ...
(Date:7/10/2014)... whole fresh avocado with either an orange-colored tomato sauce ... and beta-carotene) absorption and conversion of these carotenoids to ... research (1) published in The Journal of ... involved in reproductive health and growth promotion; helps support ... properties. Provitamin A carotenoids, like alpha- and beta-carotene, impart ...
(Date:7/10/2014)... in the West African nation Burkina Faso today ... Sayana Press has the potential to increase access ... system and in communities by combining a lower-dose ... medroxyprogesterone acetate)with the BD Uniject injection system. , ... countries expected to begin introducing Sayana Press in ...
Breaking Biology News(10 mins):Feedback control could be key to robust conservation management 2New research: Fresh avocado enhances absorption of essential nutrients for healthy living 2Injectable contraceptive launched in Burkina Faso to expand choice and address unmet need 2Injectable contraceptive launched in Burkina Faso to expand choice and address unmet need 3
... of Oceanography at UC San Diego have completed a ... Northwest Mexico and the results could have far-ranging implications ... area. The scientists, led by Scripps postdoctoral researcher ... the region that includes Baja California as well as ...
... the genome--the genetic code--of orangutans. This new tool may be ... captive and wild orangutans. The new map of the orangutan ... of the evolution of primates, including humans. Partially ... in the Jan. 27 issue of Nature . It ...
... Society of Plant Biologists (ASPB) community are among the 503 ... Advancement of Science (AAAS). These individuals will be recognized for ... to be held on February 19, 2011, during the AAAS ... a certificate and a blue and gold rosette as a ...
Cached Biology News:Study finds common ground for ecosystems and fishing in Northwest Mexico 2Scientists determine what makes an orangutan an orangutan 2Scientists determine what makes an orangutan an orangutan 328 ASPB members elected as AAAS Fellows 2