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Selexis SA and the University of Lausanne Announce the Complete Sequencing of the Selexis SURE CHO-M Genome
Date:3/23/2011

eir CMC documentation packages for regulatory filings with the FDA and EMA. In the near future, Selexis will be in a very strong position to utilize the data and genome sequence to engineer new CHO cell lines with defined specificities. More importantly, our engineered CHO cell lines will have enhanced expression capacity, especially for difficult to express recombinant proteins such as blood clot factors or fusion proteins, thus yielding therapeutics of higher quality," said Igor Fisch, CEO, Selexis SA. "The sequencing of our proprietary Selexis SURECHO-M Cell Line was a major accomplishment and a priority for Selexis in the continued improvement of our SURE Technology Platform."

Today, CHO cell lines used in the manufacturing of recombinant biologic therapeutics are from multiple origins and the variations between the CHO genomes are poorly understood. Additionally, the genetic characterization of genetically modified CHO cell lines producing recombinant protein drugs can still be quite challenging, especially when DNA amplification methods have been used to create the cell lines. Thus, regulatory agencies are increasingly looking towards more thorough filing packages. With the improvement of sequencing and genomics technologies, it is now possible to build a genomic map of particular manufacturing cell lines to finely characterize the genetic and production characteristics. Sequencing of the Selexis SURECHO-M Cell Line genome represents one of the first efforts to take genomic scale technology and apply it to industrial biologic manufacturing and regulatory activities.

Selexis and its academic collaborators will continue to work on the data analysis and genome assembly from this work. In addition to allowing more accurate manufacturing of therapeutics, this data will be used to advance the study of gene regulatory networks and expression in the Selexis SURECHO-M Cell Line as well as to improve the quantity and quality of its biologic production ca
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