Navigation Links
See-through organs and bodies will accelerate biomedical discoveries
Date:7/31/2014

rgans and bodies, in part by making the process faster. First, they identified the optimal hydrogel that allows detergents to quickly remove lipids from tissue using an approach named passive CLARITY technique (PACT). To markedly speed up the clearing process without causing tissue damage, they introduced an innovative procedure called perfusion-assisted agent release in situ (PARS), which involves directly delivering the hydrogel and clearing reagents into the bloodstream of intact rodents. The reagents diffused throughout the tissues and completely clarified organs such as the kidney, heart, lung, and intestine within 2 to 3 days, while the whole brain and entire body cleared within 2 weeks.

The researchers also developed a recipe for refractive index matching solution (RIMS), which enables the long-term storage of cleared tissue and imaging thick, cleared tissue using a conventional confocal microscope. The new methods allow for the analysis of intact connections between cells as well as structures and molecules within single cells using standard genetic and molecular biology techniques. "Our easy-to-use tissue clearing protocols, which employ readily available and cost-effective reagents and equipment, will make the subcellular interrogation of large tissue samples an accessible undertaking within the broader research and clinical communities," Gradinaru says.


'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Dr. Rongxiang Xu to Reveal How Human Organs can Achieve Self-Regeneration during His Acceptance of the International Golden Biatec 2013 Award
2. Damaged Tissues and Organs Could be Repaired With New Scaffolding Technique
3. Dr. Rongxiang Xu, Owner of Patented Technology to Regenerate Damaged Organs, Announces Lawsuit Against 2012 Nobel Laureate Dr. Shinya Yamanaka
4. Findings could be used to engineer organs
5. Engineered anti-toxin antibodies improve efficacy
6. Monoclonal Antibodies Market in Colorectal Cancer to 2019
7. Industry Shares, Size, Trend, Analysis, and Forecasts Report Available Online by Researchmoz.us
8. The Engineered T-Cell Receptor in Fusion Proteins, Antibodies & Cells: Emerging Opportunities for the Biopharmaceutical Industry
9. NKT Therapeutics Identifies Novel anti-iNKT Antibodies for Depleting or Activating iNKT Cells
10. Monoclonal Antibodies Market in Breast Cancer to 2019
11. Identifying targets of autoantibodies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
See-through organs and bodies will accelerate biomedical discoveries
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application and ... analyzes the global market on the basis of ... details such as the key drivers, current trends ... Browse 81 Market Data Tables and 29 Figures ... “1,6-Hexanediol Market by Application and by Geography - ...
(Date:10/18/2014)... The Asian Electronic Medical Record (EMR) market report defines ... forecast of revenue. The electronic medical record market in the ... 2018, at a CAGR of 9.4% from 2013 to 2018. ... Record (EMR) market, to get an idea of the in-depth ... of the market in the same region, and is supported ...
(Date:10/18/2014)... The “Global Diagnostic Electrocardiograph (ECG) Market by Product ... Research Center, Physician Office, Nursing Homes), by Lead ... provides a detailed overview of the major drivers, ... impacting the global diagnostic ECG market along with ... share analysis. , The global diagnostic ECG market ...
(Date:10/17/2014)... 2014 For the seventh consecutive ... published in today’s print issue of Science magazine. ... Employers Survey polled employees in the biotechnology, pharmaceutical ... employers. Rankings were determined based on responses ... their companies on 23 characteristics, including financial strength, ...
Breaking Biology Technology:1,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... With Another Antidepressant Can Help Adults Living With ... Adequate Symptom Relief -(1), PRINCETON, N.J. and ... BMY ) and Otsuka Pharmaceutical Co.,Ltd. announced today ... the supplemental New Drug Application for ABILIFY(R),(aripiprazole) as ...
... HD*PET, Symbia(R) TruePoint(TM) SPECT-CT and Symbia E ... Nov. 20 From,innovative new product solutions ... Solutions (http://www.usa.siemens.com/medical ) is,propelling the field ... across,clinical areas, including oncology, neurology and cardiology, ...
... ET on November 27, 2007, CAMBRIDGE, Mass., Nov. ... announced its participation,in the Lazard Capital Markets Fourth Annual ... the New York Palace Hotel in New York,City. Mark ... presenting at 2:00 pm ET on Tuesday, November 27, ...
Cached Biology Technology:U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 2U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 3U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 4U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 5U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 6U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 7U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 8U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD) 9Delivering Molecular Imaging Solutions Across Clinical Specialties: Siemens Showcases New Technologies at RSNA 2007 2Delivering Molecular Imaging Solutions Across Clinical Specialties: Siemens Showcases New Technologies at RSNA 2007 3Delivering Molecular Imaging Solutions Across Clinical Specialties: Siemens Showcases New Technologies at RSNA 2007 4Delivering Molecular Imaging Solutions Across Clinical Specialties: Siemens Showcases New Technologies at RSNA 2007 5Targanta to Present at Lazard Capital Markets Fourth Annual Healthcare Conference 2
(Date:10/16/2014)... infections and worldwide claims the lives of 160,000 ... University have succeeded in developing a promising vaccination ... , Xavier Saelens (VIB/UGent): "We discovered a new ... development of a novel approach to vaccination against ... small children and elderly people." , RSV: ...
(Date:10/15/2014)... biophysics textbook and it describes how life functions and ... into biological systems and provides an understanding of the ... how our genes make proteins that control the dynamics ... an organism. It quantifies the principles of life and ... on both large and small scales. The book is ...
(Date:10/15/2014)... Fred Alt will be awarded the 44th Rosenstiel Award ... for his pioneering research exploring the mechanisms of genomic ... cancer cells. Alt is the second alumnus to win ... Nobel Prize in 2003. , Alt is the Charles ... at Harvard Medical School and an investigator at the ...
Breaking Biology News(10 mins):New perspectives for development of an RSV vaccine 2New book about life as seen from physics 2Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2
... distinguish between the majority of plant species on Earth has ... Proceedings of the National Academy of Sciences journal today (Monday ... to identify plants using a small sample, could lead to ... species-rich areas like rainforests. It could also lead to accurate ...
... In the second space age, human spaceflight may no ... clever engineers are aggressively blazing new trails into the ... space tourism, ultra fast point-to-point earth travel and even ... pm, Perimeter Institute will host science journalist and author ...
... Feb. 4 Material Technologies,Inc. (OTC Bulletin Board: ... inspection firms last week. Company officers and inspectors,attended ... week to learn how to,implement an EFS inspection, ... analysis of the data, and the preparation of ...
Cached Biology News:DNA 'barcode' identified for plants 2DNA 'barcode' identified for plants 3Material Technologies Holds First Electrochemical Fatigue Sensor Training for Private Inspection Firms 2Material Technologies Holds First Electrochemical Fatigue Sensor Training for Private Inspection Firms 3
Tracker Datamatrix RS-1* reads 96 2D Bar-coded tubes within 20 seconds....
Hybridization cassette for one slide...
Complete cell culture media with cytokines...
Request Info...
Biology Products: