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Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain
Date:1/19/2009

inues to support the activities of the Neuraminidase Inhibitor Susceptibility Network (NISN).

Sensitivity of H5N1 (bird flu) to Tamiflu

Recently published data confirms that the H5N1 avian influenza (bird flu) strain remains sensitive to Tamiflu. Greater than ninety nine percent of H5N1 samples studied did not exhibit mutations that confer oseltamivir resistance.(3)

According to Benjamin Schwartz, MD, CDC National Vaccine Program Office, "the mutations that have made the H1N1 virus resistant are unlikely to occur in a pandemic virus, so therefore we have not changed our recommendations for planning and stockpiling".(4) Tamiflu remains the World Health Organization's "primary recommended antiviral agent of choice for the treatment of A(H5N1) virus infections".(5)

References

(1) EISS - Weekly Electronic Bulletin Week 2 :05/01/2009-11/01/2009 16 January 2009, Issue No 287

(2) The Centres for Disease Control and Prevention (CDC). Interim Antiviral Guidance for 2008-09 http://www2a.cdc.gov/HAN/ArchiveSys/ViewMsgV.asp?AlertNum=00279 Accessed 6 January 2009

(3) Hill AW et al. Evolution of drug resistance in multiple distinct lineages of H5N1 avian influenza. Infections, Genetics and Evolution. 2008

(4) 'Cost, resistance aired in HHS webcast on antivirals'. CIDRAP News. December 17 2008 http://www.cidrap.umn.edu/cidrap/content/influenza/panflu/news/dec1708webinar. html Accessed 16 January 2009

(5) Clinical management of human infection with avian influenza A(H5N1) virus. World Health Organization. 15 August 2007 http://www.who.int/csr/
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