Navigation Links
Scripps Research Institute Scientists Find Antibody that Transforms Bone Marrow Stem Cells Directly into Brain Cells
Date:4/22/2013

ts the marrow-suppressing side effect of cancer chemotherapy.

The team soon isolated one antibody type or "clone" that could activate the GCSF receptor and stimulate growth in test cells. The researchers then tested an unanchored, soluble version of this antibody on cultures of bone marrow stem cells from human volunteers. Whereas the GCSF protein, as expected, stimulated such stem cells to proliferate and start maturing towards adult white blood cells, the GCSF-mimicking antibody had a markedly different effect.

"The cells proliferated, but also started becoming long and thin and attaching to the bottom of the dish," remembered Xie.

To Lerner, the cells were reminiscent of neural progenitor cells—which further tests for neural cell markers confirmed they were.

A New Direction

Changing cells of marrow lineage into cells of neural lineage—a direct identity switch termed "transdifferentiation"—just by activating a single receptor is a noteworthy achievement. Scientists do have methods for turning marrow stem cells into other adult cell types, but these methods typically require a radical and risky deprogramming of marrow cells to an embryonic-like stem-cell state, followed by a complex series of molecular nudges toward a given adult cell fate. Relatively few laboratories have reported direct transdifferentiation techniques.

"As far as I know, no one has ever achieved transdifferentiation by using a single protein—a protein that potentially could be used as a therapeutic," said Lerner.

Current cell-therapy methods typically assume that a patient's cells will be harvested, then reprogrammed and multiplied in a lab dish before being re-introduced into the patient. In principle, according to Lerner, an antibody such as the one they have discovered could be injected directly into the bloodstream of a sick patient. From the bloodstream it would find its way to the marrow, and, for example, c
'/>"/>

SOURCE Scripps Research Institute
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Philanthropist John Moores Gives $2 Million to The Scripps Research Institute to Develop River Blindness Field Test
2. Scripps Research Institute scientists find easier way to make new drug compounds
3. Michael A. Marletta Takes Office as New President of Scripps Research Institute
4. Biotechnology Market (Biopharmacy, Bioservices, Bioagri, Bioindustrial) Is Expected to Reach USD 414.5 Billion Globally in 2017: Transparency Market Research
5. Verified Clinical Trials Exhibits at the Annual 2013 Partnerships In Clinical Trials to Discuss the Professional Research Subject and the Clinical Trial Database Registry
6. Israel’s Top BioEnergy Researchers Are Arriving Today at Oak Ridge National Laboratory For Deliberations to Establish U.S.-Israel Collaboration
7. Cord Blood Banking Industry: 2013 Growth Opportunities Analysis in New Market Research Report at ReportsnReports.com
8. Bayer CropScience Breaks Ground on New Greenhouse For Cotton Research And Development in Memphis, Tennessee
9. Amphora Research Systems welcomes Advanced Polymer Monitoring Technologies
10. Lilly Acquires Novel Tau Tangle Diagnostic Program to Bolster Alzheimers Disease Research and Development
11. Preliminary Research, Led By Dr. Vincent Giampapa, Finds Aged Adult Stem Cells Can Be Functionally Reprogrammed To Act Like Younger Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... (PRWEB) July 10, 2014 Unraveling life’s ... together. The Archer Family purchased a DNA ... DNA, but ended up with a lifetime of memories, ... within the family members’ DNA genuinely brought the family ... to search deeper into genetic history and prior to ...
(Date:7/10/2014)... 10, 2014 Senior supply chain management ... associations, addressed the challenges of “Reducing Cost, Lead Time, ... through strategic sourcing. Describing the partnership of the Bio ... Chain Management Institute ( SCMI) of the University ... 24 at the Kroc Institute of Peace and Justice ...
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)... University of Adelaide research may help in the fight ... can detect tiny quantities of explosives with the use ... the journal Sensors and Actuators B: Chemical , ... can detect explosives in concentrations as low as 6.3 ... of only a few minutes. , "Traditionally explosives detection ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2
... Doping may be a no-no for athletes, but researchers ... was key in getting unprecedented power conversion efficiency from ... Graphene solar cells are one of industry,s great ... future. But previous attempts to use graphene, a single-atom-thick ...
... 25, 2012  Oncobiologics, Inc. announced today that it ... biopharmaceutical industry experts. Stephen J. McAndrew, Ph.D. is ... Benn, Ph.D. has joined the company as Vice ... announced its new Scientific Advisory Board, which will ...
... 24, 2012  For years, doctors and microbiologists have sent ... body for examination. These tests take days to get ... Donald Spector, a well-known, serial entrepreneur-inventor and Chairman of ... few institutionally accredited schools of Acupuncture and Massage Therapy ...
Cached Biology Technology:University of Florida physicists set new record for graphene solar cell efficiency 2Oncobiologics Fills Key Leadership Positions and Names Scientific Advisory Board 2Oncobiologics Fills Key Leadership Positions and Names Scientific Advisory Board 3College Chairman And Prolific Inventor Develops Life-Saving, Real-Time Diagnostic Technologies 2College Chairman And Prolific Inventor Develops Life-Saving, Real-Time Diagnostic Technologies 3
(Date:7/10/2014)... , July 3, 2014 Research ... addition of the "Global Gesture Recognition & ... - Forecasts to 2020" report to their ... Global Gesture Recognition & Touch-Less Sensing Market ... around for a while, but the companies were ...
(Date:7/10/2014)... 2014 According to a new ... Control Systems Market Global Forecast, Market Share, Size, Growth ... Access Control systems market was valued at USD 15,406.1 ... a CAGR of 12.6% from 2014 to 2019, to ... 2019. Browse the full Electronic Access Control ...
(Date:7/10/2014)... 2014  Acuity Market Intelligence today released forecasts from "The ... that the global market for National Electronic ID (eID) programs ... During this time, the number of National eID cards in ... Asia , with its vast population, will dominate ... issued, while Europe trails a distant ...
Breaking Biology News(10 mins):Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2
... green chemical technologies will play a key role helping ... a wider range of products from biorefineries, according to ... Director of the University,s Green Chemistry Centre of Excellence, ... the American Association for the Advancement of Science (AAAS) ...
... Feb. 18, 2011 USDA,s National Institute of Food ... (CAP) representing a major scientific investment in studying the ... NIFA Director Roger Beachy made the announcement today at ... Advancement of Science in Washington, D.C. "Climate change ...
... the first time been cloned as seeds. The research by ... 18 in the journal Science , is a major ... traits from generation to generation. Most successful crop ... biology at UC Davis and an author of the paper. ...
Cached Biology News:NIFA announces grants to study the effects of climate change on agricultural and forest production 2NIFA announces grants to study the effects of climate change on agricultural and forest production 3Plants cloned as seeds 2
Request Info...
... include: ,ICC and IHC Protocol Development ... ,Antibody Screenings in Animal or Human ... of Cells and Tissues ,Peroxidase, Alkaline ... Fluorescent, or Electron Microscopy ,Protein Localization ...
Request Info...
Request Info...
Biology Products: