Navigation Links
Scripps Research Institute Highlights Groundbreaking Work of aTyr Pharma Scientific Co-Founder
Date:6/8/2009

Research Published by Scripps Associate Professor Xiang-Lei Yang Further Validates aTyr Pharma's Discovery Engine for Proprietary Drugs

SAN DIEGO, June 8 /PRNewswire/ -- The June 1st, 2009 edition of The Scripps Research Institute (TSRI) News & Views highlights newly published research from the laboratory of Associate Professor Xiang-Lei Yang, a scientific co-founder of aTyr Pharma. Professor Yang's latest study (Chemistry & Biology, vol. 16, pp. 531-539) builds on her previous revolutionary research with an essential enzyme of protein synthesis, tyrosyl tRNA synthetase. Synthetases are fundamental components of protein synthesis machinery in all organisms, but human synthetases have hidden secrets: unrelated cell signaling activities that play key roles in balancing the complex human system. By proving that cytokine-disrupting mutations in the tyrosyl tRNA synthetase do not disturb the activity required for protein synthesis, Professor Yang's research demonstrates that human synthetases have evolved mechanisms for switching on new cell signaling activities that are normally masked in the synthetase enzymes. The novel cell signaling activities associated with the tyrosyl tRNA synthetase extends to the whole family of synthetases and is the basis of aTyr Pharma's discovery engine for developing an entirely new class of protein drugs.

According to Jeff Watkins, CEO of aTyr Pharma, "By separating specific residues in the human tyrosyl tRNA synthetase required for novel cytokine activities from those involved in the protein synthesis activities, Professor Yang has proven that these naturally occurring activities hidden in the synthetases have a role in normal human physiology. Identification of these novel cell signaling proteins that can be used to restore homeostasis in patients with inflammatory, cardiovascular and metabolic diseases is the discovery engine for aTyr Pharma's product development
'/>"/>

SOURCE aTyr Pharma
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Confirmation of Bogoch Replikins Influenza Patents by Harvard-CDC and Scripps-Crucell Data
2. RainDance and Scripps to Collaborate on Targeted Sequencing for Wellderly Study
3. Instrumentation Laboratory Ships 1000th GEM Premier 4000 Analyzer to Scripps Health
4. The Scripps Translational Science Institute Joins The MetaMiner Cardiac Consortium
5. Researchers solve bloodcurdling mystery
6. Akaza Research to Present and Exhibit at Upcoming DIA Annual Meeting
7. Sigma-Aldrich Honored With CIO 100 Award for Innovative Web Research Tool, Your Favorite Gene powered by Ingenuity
8. Kornberg Associates Architects Selected to Design Research Areas of Malaysia Genome Institute
9. First ASMS Hites Award for Outstanding Research Publication Presented to Prof. Alison Ashcroft for Her Use of Waters Synapt HDMS System to Explore Protein Complexes
10. Secret of sandcastle construction could help revive ancient building technique, researchers say
11. Prometheus Research Signs 3-Year Contract With Simons Foundation to Expand HTSQL Informatics System for Autism Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... Denmark , July 30, 2015 ... biotechnology company that applies its innovative TransCon technology ... positive top-line results from a six-month Phase 2 ... once-weekly TransCon Growth Hormone in 53 treatment-naïve, pre-pubertal ... "We are extremely pleased with the top-line ...
(Date:7/30/2015)... Bedford, NH (PRWEB) , ... July 30, 2015 ... ... efficiency homogenizer for advanced fluid applications and designed for continuous operation up to ... clean-in-place and sterilization-in-place, ensuring safety, efficiency, and preventing toxic contamination. , The Pony™ ...
(Date:7/29/2015)... -- US-Australian drug discovery company, Novogen Limited (ASX: NRT; ... to progressing its ground-breaking technology platforms to Phase 1 ... the Company delivers the best value for shareholders. ... said the Company currently had an extensive program of ... and academic partnerships and initiatives, and he was working ...
(Date:7/29/2015)... FRANCISCO , July 29, 2015  AsureQuality ... mobile molecular testing for applications in food and ... hand-held, battery powered real-time PCR device, the Freedom4. ... farm right through to the supermarket shelf for ... This includes involvement in animal disease control and ...
Breaking Biology Technology:Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2
... the most important frontiers in medicine. Although no significant achievements for curing ... terms of developing such approaches. By the year 2015, global market for ... ... CA (PRWEB) November 4, 2008 -- Advancements in gene therapy have provided ...
... When Albrecht Durer and other Renaissance artists painstakingly etched ... and transferred the images to paper with a press, ... same technique would uncover the secrets of human cells. ... have borrowed a technique from such "intaglio" printing to ...
... VALENCIA, Calif., Nov. 3 MannKind Corporation,(Nasdaq: MNKD ... and cancer, announced today that it will present at,the ... 10, 2008 at 9:55 AM (EST) at the New ... can access a link to the live web cast ...
Cached Biology Technology:World Gene Therapy Market to Reach $484 Million by 2015, According to New Report by Global Industry Analysts, Inc. 2World Gene Therapy Market to Reach $484 Million by 2015, According to New Report by Global Industry Analysts, Inc. 3Protein-printing technique gives snapshots of immune system defense 2Protein-printing technique gives snapshots of immune system defense 3
(Date:7/21/2015)... 21, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market ... that it has filed provisional patent 62/192218 for ... This invention highlights next generation payment ... account, but also the user using unique personal ...
(Date:7/13/2015)... Conn. , Jul. 13, 2015 NXT-ID, ... "Company"), a biometric authentication company focused on the ... has filed provisional patent 62/188684 for ... achieves another new convenient and secure method to ... new, innovative payment methods, introduced with its groundbreaking ...
(Date:7/9/2015)... , July 9, 2015  Synaptics Inc. ... of human interface solutions, today announced a ... first fully hardware encapsulated fingerprint sensor and ... technology is literally off the grid, isolating ... matching within the fingerprint sensor to provide ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... (CHICAGO) Women with the BRCA1 or BRCA2 ... risk of breast and ovarian cancer, can safely take ... removal of their ovaries, according to new research from ... Pennsylvania which will be presented Monday, June 6 during ...
... in partnership with academic publishers Pensoft, creates so-called ... species observations, specimen collections and other biodiversity data. ... version of GBIF,s Integrated Publishing Toolkit (IPT 2.0.2) ... information about a dataset accessible via the GBIF ...
... that the critically short supply of livers for organ ... with a substance that protects them from damage after ... in ACS, journal Molecular Pharmaceutics . Ram ... transplants has grown over the years, though the number ...
Cached Biology News:Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal 2Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal 3New incentive for biodiversity data publishing 2
... aptamer screening and binding optimization and built ... on-chip synthesis platform. These microarrays are available ... Microarray Service. Probe Content ... greater than 1500 known aptamer sequences. Add ...
... comprehensive service for custom peptide microarray ... synthesized on Paraflo microfluidic chips for ... serum samples. This comprehensive service includes ... assays using sample(s) provided by you, ...
... screening and binding optimization and built on ... synthesis platform. Thousands of customer specified sequences ... can provide assistance with custom sequence design. ... our comprehensive DNA/RNA Aptamer Microarray Service. ...
... commonly used as a fusion partner when ... GSTTag sequence has been reported to enhance ... solubility of its fusion partners. When expressed ... fusion proteins can be purified with immobilized ...
Biology Products: