Scientists use math modeling to predict unknown biological mechanism of ...(director of the London Research Institut...)

Date:10/15/2009

director of the London Research Institute of Cancer Research UK, and members of his Chromosome Replication Lab, on experiments that were designed to test this prediction. The results, published online in the journal Nature Molecular Systems Biology on October 13, 2009, verify the computationally predicted mechanism.

A DNA microarray is a glass slide that holds an array of thousands of specific DNA sequences acting as probes for different genes, making it possible to record the activity of thousands of genes at once. Making sense of the massive amount of data DNA microarrays generate is a major challenge. In her Genomic Signal Processing Lab, Alter creates mathematical models by arranging the data in multi-dimensional tables known as tensors. She then develops algorithms to uncover patterns in these data structures, and is able to relate these patterns to mechanisms that govern the activity of DNA and RNA in the cell.

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Contact: Becky Rische brische@mail.utexas.edu 512-471-7272 University of Texas at Austin Source:Eurekalert

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