Navigation Links
Scientists use light to control proteins
Date:10/16/2008

A team of researchers from Penn State and the University of Texas Southwestern Medical Center has discovered a way to use light to control certain proteins that catalyze biochemical reactions. "This is one of the first examples of someone successfully controlling the activity of a protein using light," said Stephen Benkovic, Penn State Evan Pugh Professor of Chemistry, holder of the Eberly Family Chair in Chemistry, and one of the team's leaders. "The technology one day could be expanded to have multiple uses, including the ability to turn off the activities of some disease-causing proteins in the cell," he said. The team's results will appear in the 17 October issue of the journal Science.

In their experiment, the scientists designed a hybrid protein by inserting a light-sensing protein from an oat plant into an enzyme -- a type of protein that catalyzes biochemical reactions -- from the bacterium E. coli. After engineering the two components together, the researchers found that the enzyme's activity could be manipulated by shining a light on the light-sensing protein, which the scientists refer to as a "domain." "The technology works like a light switch," said Benkovic. "When we shine a light on the light-sensing domain, the enzyme's activity increases, and when we shut the light off, the enzyme's activity decreases."

According to Jeeyeon Lee, a postdoctoral scholar in the Penn State Department of Chemistry and one of the paper's authors, the team had to consider a number of factors when designing the hybrid protein, including the protein's shape, or what is referred to as its conformation. "The conformation of a protein is important in determining its function," she said. "Without the proper conformation, our protein would not have responded to the light."

Another important factor that the team had to consider was the proper location on the enzyme into which the light-sensing protein from the oat plant would be i
'/>"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Nu Skin Scientists Correlate the Appearance of Aging With arNOX Free Radical Generator
2. Scientists engineer superconducting thin films
3. New nanoscale process created by UCSB scientists will help computers run faster and more efficiently
4. CU scientists create worlds thinnest balloon -- just one atom thick
5. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
6. Brewing better beer: Scientists determine the genomic origins of lager yeasts
7. Vermillion and Stanford Scientists Receive Best Research Award From the PAD Coalition
8. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
9. Scientists peel away the mystery behind golds catalytic prowess
10. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
11. Scientists grow nanonets able to snare added energy transfer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists use light to control proteins
(Date:5/21/2015)... 2015 Specialty Pharmacy Times has ... admitted to BPA Worldwide as a business publication ... audience data for Specialty Pharmacy Times based on ... becoming a member of BPA Worldwide, Specialty Pharmacy ... clients with the most reliable, unequaled data,” said ...
(Date:5/21/2015)... NOVATO, Calif. , May 21, 2015 /PRNewswire-USNewswire/ ... Orrin Hatch (R-UT) and Amy ... Product Extensions Now Accelerating Cures & Treatments, or ... 150 rare disease patient advocacy organizations, this bipartisan ... effective, and affordable medicines to rare disease patients ...
(Date:5/21/2015)... 21, 2015  CytRx Corporation (NASDAQ: CYTR ... in oncology, today announced positive updated results from ... for the treatment of unresectable glioblastoma multiforme (GBM), ... multisite trial is designed to investigate the preliminary ... tumors have progressed following prior treatment with surgery, ...
(Date:5/21/2015)... 2015 Veolia’s environmental monitoring technology ... American distribution agreement with VWR to distribute TECTA™ ... more than 160 years of experience, VWR, a ... laboratory and production facilities, has cultivated a value ... services to enable science. Endetec’s TECTA™ B16, ...
Breaking Biology Technology:Specialty Pharmacy Times Joins BPA Worldwide 2Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2
... & Seidelmann Subspecialty,Radiology (F&S) has added additional ... appointment of Richard Dyke as senior vice ... Dyke will be responsible for new client,acquisition ... business,development through industry partner channels, strategic marketing, ...
... 13 PharmAthene, Inc.,(NYSE Alternext US: PIP), a ... threats, today reported,financial and operational results for the ... For the third quarter of 2008, PharmAthene ... in the same period of 2007. For the ...
... SPEX ) reported a net loss for the ... million ($0.12 per share) and $4.8 million,($0.34 per share), ... commercialization of Naturlose as a treatment for Type,2 diabetes ... ended,September 30, 2008, compared to approximately $4.5 million for ...
Cached Biology Technology:Franklin & Seidelmann Adds Richard Dyke to Senior Management Team as Senior VP, Sales/Marketing 2Pharmathene Reports Third Quarter 2008 Financial and Operational Results 2Pharmathene Reports Third Quarter 2008 Financial and Operational Results 3Pharmathene Reports Third Quarter 2008 Financial and Operational Results 4Pharmathene Reports Third Quarter 2008 Financial and Operational Results 5Pharmathene Reports Third Quarter 2008 Financial and Operational Results 6Pharmathene Reports Third Quarter 2008 Financial and Operational Results 7Spherix Reports 3rd Quarter Earnings 2
(Date:4/6/2015)... Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... patent 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA ... NXT-ID introduces a new revolutionary method ... surrounds the use of miniature antenna modules for ...
(Date:4/2/2015)... , April 2, 2015 At its 2015 ... Lake City , the American College of Medical ... new directors to its Board.  Members of the ACMG ... and for forming and advancing its policies and programs. ... profession. "It,s an eventful time in medical ...
(Date:4/2/2015)... Sweden , April 2, 2015 ... its touch fingerprint sensor FPC1025 from the distributor World ... will commence during Q2 2015 although the major part ... The sensors will be used by smartphone manufacturers in ... 110 MSEK is included in the communicated revenue guidance ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... Eight supply chain professionals were elected in June by the ... the seven existing members of SCC,s board. Newly elected board members, ... as follows: , , , , ... Hewlett Packard , Jane Barrett, Research ...
... generation biofuels made from inedible plant material, including ... numerous scientific studies have shown them to be ... transportation needs. However, before we can begin to ... numerous barriers must be overcome, starting with finding ...
... disorders are a global problem and represent one of the ... are some 500 million people suffering from mental disorders, and ... the leading causes of disease burden. What makes the situation ... is expected to grow for a variety of reasons: an ...
Cached Biology News:New technique can fast-track better ionic liquids for biomass pre-treatments 2New technique can fast-track better ionic liquids for biomass pre-treatments 3New technique can fast-track better ionic liquids for biomass pre-treatments 422nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey 222nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey 322nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey 422nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey 522nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey 622nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey 722nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey 8
... The H2OBIT is a fully licensed, high ... simultaneous processing of up to 24 microplates. This ... 384-well plates. ,A robotic arm rapidly transfers ... resulting in temperature ramping times that are considerably ...
... Rabbit polyclonal to Dideoxycytidine Dideoxycytidine is ... be effective in inhibiting retroviral activity. ... BSA. Specificity: The specificity of ... ratio of the moles of ddC to moles ...
... MSC series of Class II Biological ... and certification to the world's highest ... that the cabinets cannot be adjusted ... lighting, low noise and arm rest ...
... HM-4000 Multidizer is designed with a ... orbital, rotating - all in one unit. ... Two independently operating compartments allow for hybridization ... or motion , The upper chamber ...
Biology Products: