Navigation Links
Scientists transplant nose of mosquito, advance fight against malaria
Date:2/15/2010

Scientists at Vanderbilt and Yale universities have successfully transplanted most of the "nose" of the mosquito that spreads malaria into frog eggs and fruit flies and are employing these surrogates to combat the spread of the deadly and debilitating disease that afflicts 500 million people.

The research is described in two complimentary papers, one published this week in the early online edition of the Proceedings of the National Academy of Sciences and the other which appeared online Feb. 3 in the journal Nature.

The mosquito's "nose" is centered in its antennae, which are filled with nerve cells covered with special "odorant receptors" that react to different chemical compounds. The insect ORs are comparable to analogous receptors in the human nose and taste buds on the tongue.

"We've successfully expressed about 80 percent of the Anopheles mosquito's odorant receptors in frog's eggs and in the fruit fly antennae," says Laurence Zwiebel, professor of biological sciences at Vanderbilt, whose lab performed the frog egg transplantation. The fruit-fly (Drosophila melanogaster) work was done in the laboratory of John Carlson, Eugene Higgins Professor of Molecular, Cellular and Developmental Biology at Yale.

Both accomplishments are part of a five-year project supported by the Grand Challenges in Global Health Initiative funded by the Foundation for NIH through a grant from the Bill & Melinda Gates Foundation with the goal of producing novel ways to inhibit the spread of malaria. Scientists from the Wageningen University in the Netherlands, the African Insect Science for Food and Health Institute in Kenya, Ifakara Health Institute in Tanzania and the Medical Research Council Laboratories in the Gambia are also participating in the project.

Previously, scientists have used frog eggs to study the olfactory receptors of moths, honeybees and fruit flies. DNA that encodes insect receptors are injected into
'/>"/>

Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Penn material scientists turn light into electrical current using a golden nanoscale system
2. Seeing the quantum in chemistry: JILA scientists control chemical reactions of ultracold molecules
3. NFCR Scientists Discover Brain Tumor's “Escape Path”
4. Scientists achieve first rewire of genetic switches
5. Scientists create worlds first molecular transistor
6. 6 PNNL scientists elected AAAS fellows
7. Particle Size Distribution Technologies at American Association of Pharmaceutical Scientists (AAPS) Annual Meeting 2010
8. Argonne Scientists Use Bacteria to Power Simple Machines
9. Online Video of InVitria's Zap-CHO Helps Scientists Maximize CHO Cell Culture Performance
10. Scientists Rediscover Gene Target for Cancer Therapy
11. MEDINA Scientists Select Genedata Screener for Lead Discovery from Natural Products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists transplant nose of mosquito, advance fight against malaria
(Date:7/30/2015)... 2015   GenoSpace , a leading provider ... analysis of genomic and other biomedical data, today ... the company as Vice President of Sales and ... "GenoSpace partners with its customers ... and explore complex sets of genomic, phenotypic and ...
(Date:7/30/2015)... CA (PRWEB) , ... July 30, 2015 , ... ... successful completion of a field clinical study of its canine osteoarthritis stem cell ... with Aratana Therapeutics (Kansas City, KS) and will be marketed in the US ...
(Date:7/30/2015)... 30, 2015 Ascendis Pharma A/S (Nasdaq: ... its innovative TransCon technology to address significant unmet ... a six-month Phase 2 study to evaluate the ... in 53 treatment-naïve, pre-pubertal children with growth hormone ... pleased with the top-line results from our Phase ...
(Date:7/30/2015)... ... July 30, 2015 , ... GEA's ... designed for continuous operation up to 1500 bar. The sanitary design gauge of ... preventing toxic contamination. , The Pony™ NS2006L homogenizer is an ideal solution for ...
Breaking Biology Technology:GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2
... ... , ... (PRWEB) October 21, 2009 -- iLife Americas, LLC, a leading developer and marketer of ... its line of iLife wellness and therapeutic products. Officially opened on September 1, 2009, ...
... -- China Medical Technologies,Inc. (the "Company") (Nasdaq: CMED ), ... advanced in-vitro diagnostic,products, today announced that it will attend the ... October 31, 2009 in Chengdu,China. , , ... China International Medical Equipment Fair, Date: ...
... created a new material that would allow a fingernail-size ... DVDs or 250 million pages of text, far exceeding ... Led by Dr. Jagdish "Jay" Narayan, John C.C. Fan ... director of the National Science Foundation Center for Advanced ...
Cached Biology Technology:iLife Americas, LLC Enters U.S. Wellness and Therapeutic Markets 2China Medical Technologies to Exhibit its Products at China International Medical Equipment Fair in Chengdu, China 2New material could boost data storage, save energy 2
(Date:7/31/2015)... , July 31, 2015 The 10 th ... be held by BGI from October 22-25, 2015, in ... The conference is celebrating its 10 th anniversary this ... of the world,s most influential annual meetings in the ,omics, ... enjoyable scientific gatherings. ICG-10 focuses on recent ...
(Date:7/23/2015)... -- Aware, Inc. (NASDAQ: AWRE ), a leading supplier ... its second quarter ended June 30, 2015.  ... a decrease of 33% compared to $6.8 million in the ... of 2015 was $0.3 million, or $0.01 per diluted share, ... in the same period a year ago.  ...
(Date:7/21/2015)... NEW YORK , July 21, 2015 /PRNewswire/ ... critical systems, as seen in the recent U.S. ... enterprises a solution to the infosec conundrum, but ... data is stored. To address this dilemma, Biometrics-as-a-Service ... of its Biometric Tokenization SDK for third party ...
Breaking Biology News(10 mins):The 10th International Conference on Genomics (ICG-10) to Open in October 2Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4
... CITY After years of working toward this goal, scientists ... isolate cancer stem cells in tumors so they can target ... A research team at the University of Oklahoma led ... a particular protein only appears in stem cells. Until now, ...
... KNOXVILLE -- Two research groups from the University of ... National Science Foundation to create new graduate research and ... The grants, called Integrative Graduate Education and Research Traineeships, ... graduate students to UT Knoxville for two unique programs ...
... University of Nottingham are to investigate the effect of nutrients ... of keeping up our strength as we get old. ... and Health in Derby, want to know what sort of ... to slow down the natural loss of skeletal muscle with ...
Cached Biology News:UT Knoxville wins 2 $3M National Science Foundation research and education grants 2A stronger future for the elderly 2
Plasmid expressing the LacZ reporter gene....
... flasks have triple baffles located at the ... maximal oxygen transfer to culture medium. These ... wide range of optional caps are available ... caps for ease of sorting and identification ...
...
... mouth PYREX Fernbach-style culture flask is designed for ... volume ratio. It can also be used in ... edges to achieve maximal oxygen transfer to culture ... and accepts cotton plugs or No. 13 rubber ...
Biology Products: