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Scientists report successful vaccine developed against deadly Nipah virus
Date:8/8/2012

h-level safety and security facility for working with live Nipah virus, the team of researchers, under the direction of Heinz Feldmann, M.D., Ph.D., chief of the RML, Laboratory of Virology, demonstrated that immunizing monkeys with a vaccine based on the Hendra virus attachment G glycoprotein afforded complete protection against Nipah virus infection with no evidence of disease.

"These findings are really quite promising and appear to offer a real potential treatment for either Nipah or Hendra virus infection in people," said Christopher C. Broder, Ph.D., professor of Microbiology at USU and study corresponding author.

The vaccine is a soluble portion of the G glycoprotein of Hendra virus, known as Hendra-sG, which mediates viral infection and is produced in the laboratory using molecular techniques. Lead author, Katharine Bossart, Ph.D., a USU alumna and assistant professor in the Department of Microbiology, Boston University School of Medicine, developed the Hendra-sG vaccine while a student in Dr. Broder's laboratory at USU. "Since the vaccine is only a recombinant piece of the virus, it can be produced by itself and purified, and is a type of vaccine known as a subunit, thus making it extremely safe to use," Dr. Bossart said.

According to study co-author Thomas W. Geisbert, Ph.D., professor in the Department of Microbiology and Immunology at UTMB and GNL, "This work now provides key evidence that a simple and safe recombinant vaccine against Nipah virus is possible. Demonstrating this in a nonhuman primate model is a major step forward in developing it for future therapeutic use in people."

Major support for the current study came from the NIAID, NIH, including grant U01-AI082121 awarded to Dr. Geisbert and R01-AI054715 to Dr. Broder.

"There are currently no approved vaccines for prevention of infection and disease caused by Nipah and Hendra for use people or livestock," Dr. Broder said. "The vaccine had previous
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Contact: JoAnn Sperber
jsperber@hjf.org
240-694-2163
Henry M. Jackson Foundation for the Advancement of Military Medicine
Source:Eurekalert

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