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Scientists identify mammal model of bladder regeneration
Date:10/25/2012

the hope is that we can prompt the regeneration of other organs and tissues where structure is important from the intestine and spinal cord to the heart," said Petersen.

The current study showed that the animals' bodies responded to the bladder removal by increasing the rate at which certain cells divided and grew. The most notable proliferative response occurred initially in the urothelium, the layer of tissue that lines the bladder.

As the proliferative activity in the bladder lining waned, it continued elsewhere: in the fibrous band (lamina propria) that separates the bladder lining from the bladder muscles and in the bladder muscle itself.

The researchers have several theories about how the process works, said Christ. One possibility is that cells in the bladder lining transition and become a type of stem cell that can proliferate throughout the bladder. Other theories are that cells in the bladder lining signal other cells to replicate and that injury prompts stem cells to arrive through the blood stream to repair the bladder damage.

In future studies, the scientists will work to identify the exact regenerative process and will expand the work into mice. The ability to breed mice that lack specific genes will enable the team to explore how genes and proteins may affect the regenerative process and possibly help identify therapies to prompt regeneration.


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Contact: Karen Richardson
krchrdsn@wakehealth.edu
336-716-4453
Wake Forest Baptist Medical Center
Source:Eurekalert

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