Navigation Links
Scientists identify gene vital to early embryonic cells forming a normal heart and skull
Date:6/18/2009

New research from Cincinnati Children's Hospital Medical Center highlights the critical role a certain gene and its protein play during early embryonic development on formation of a normal heart and skull.

In a study posted online June 15 by the Proceedings of the National Academy of Sciences, a research team at Cincinnati Children's reports that too little of the gene/protein SHP2 interferes with the normal developmental activity of what are called neural crest cells. These cells, which occur very early in embryonic development, migrate to specific regions of the embryo. While doing so, the cells are supposed to differentiate and give rise to certain nerve tissues, craniofacial bones or smooth muscle tissue of the heart.

"Our findings show that a deficiency of SHP2 in neural crest cells results in a failure of cell differentiation at diverse sites in the developing embryo," said Jeffrey Robbins, Ph.D., co-director of the Heart Institute at Cincinnati Children's and senior investigator of the study. "This leads to anatomical and functional deficits so severe that it precludes viability of the developing fetus."

SHP2 is a tyrosine phosphatase an enzyme that helps trigger a cascade of biochemical reactions in cells as they specify to form certain tissues.

Although the study was conducted using mouse embryos, the findings are significant in efforts to understand congenital malformations of the heart and craniofacial region in people. Especially relevant, the researchers said, is the insight gained into early molecular events during embryonic development that might help explain such birth defects.

Dr. Robbins said the findings from this study can be used to develop specific drugs that could target the affected pathway, leading to treatment of heart and craniofacial malformations. About 4 percent of human infants are born with congenital malformations. Abnormal heart development is the most common human birth de
'/>"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Israeli scientists show bacteria can plan ahead
2. Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences
3. A*STAR scientists invent the worlds only controllable molecule gear of minuscule size of 1.2nm
4. Monsanto, BASF Scientists Disclose Discovery of Gene Conferring Drought Tolerance in Corn Plants
5. Scientists create metal that pumps liquid uphill
6. Abbott Named One of the Top 10 Companies for Scientists
7. Scientists demonstrate effect of confining dielectrics on semiconductor nanowire conductivity
8. Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria
9. Scientists moving closer to artificial noses
10. Scientists discover dancing algae
11. Scientists demonstrate laser with controlled polarization
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... ON , July 11, 2014 /CNW/ - Sunovion ... approved APTIOM TM (eslicarbazepine acetate) for use as ... seizures in patients with epilepsy who are not satisfactorily ... indicated for use in patients under 18 years of ... most common neurological disorders and according to Epilepsy Canada, ...
(Date:7/10/2014)... 10, 2014 Deep Knowledge Ventures ... Forum on ‘Commercialising Longevity Research’ and welcomed a ... the London Bioscience Innovation Center for the event, ... Aging Analytics Ltd. The meeting highlighted the need ... research for age-related disease, as well as the ...
(Date:7/10/2014)... 2014 OMICS Group’s 5th International conference ... August, 2014 at Double Tree by Hilton Beijing, China ... in Analytical & Bioanalytical research methods only to facilitate ... this occasion, Dr. Srinubabu Gedela, MD of OMICS Group ... a remarkable one in bringing a unique and international ...
(Date:7/10/2014)... Capital, a firm specializing in acquiring and managing food ... the Slim-Fast brand from Unilever. Unilever will retain a ... were not disclosed. Slim-Fast is a branded ... shakes, powders, bars and snacks to retail customers throughout ... United Kingdom and Ireland.  The ...
Breaking Biology Technology:Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2
... 15, 2011 Reportlinker.com announces that a ... its catalogue: India Biotechnology ... http://www.reportlinker.com/p0553099/India-Biotechnology-in-India-Industry.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Disc This report analyzes ... US$ million by the following Key Sectors ...
... NEW BRUNSWICK, N.J., June 14, 2011 Psoriasis is ... of the world,s population or more than 125 million ... others, it is disabling. On a continuing ... an article published in the Journal of Investigative ...
... Inc. , a California-based clean technology company serving the ... yeast technology from the USDA Forest Products Laboratory (FPL) ... the fermentation of C5 sugars, such as xylose, to ... Cooperative Research and Development Agreement (CRADA) between FPL and ...
Cached Biology Technology:Reportlinker Adds India Biotechnology in India Industry 2Reportlinker Adds India Biotechnology in India Industry 3Reportlinker Adds India Biotechnology in India Industry 4Reportlinker Adds India Biotechnology in India Industry 5Reportlinker Adds India Biotechnology in India Industry 6Reportlinker Adds India Biotechnology in India Industry 7Reportlinker Adds India Biotechnology in India Industry 8Reportlinker Adds India Biotechnology in India Industry 9Reportlinker Adds India Biotechnology in India Industry 10Reportlinker Adds India Biotechnology in India Industry 11Reportlinker Adds India Biotechnology in India Industry 12Actinobac Biomed, Inc. Demonstrates In Vivo Efficacy for Psoriasis Treatment 2EdeniQ Licenses Yeast Technology from USDA 2
(Date:7/11/2014)... from the Max Planck Institute for Medical Research in ... understanding photosynthesis, the process by which the Earth first ... and which is therefore crucial for all higher forms ... the first direct visualization of a crucial event in ... specific protein complex, photosystem II, splits water into hydrogen ...
(Date:7/11/2014)... marginal division of the striatum is also involved ... degree of substance P in the striatal marginal ... and his team, College of Biophotonics, South China ... substance P receptor, neurokinin 1 was highly expressed ... normal rats. Unilateral or bilateral injection of an ...
(Date:7/11/2014)... Rio de Janeiro, Brazil- In the brains of ... mechanism that allows an electric or chemical signal ... another. Chemical synapses, which are the most abundant ... inhibitory. Synapse formation is crucial for learning, memory, ... and inhibitory synapses critical for brain function. ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2Blame it on the astrocytes 2
... French . Researchers at the Montreal ... basis of depression in male athletes with persisting post-concussion ... Archives of General Psychiatry, has important clinical implications for ... concussion. Depression is one of a number ...
... release is also available in German . ... modified bacteria produce human insulin. In future, gene therapy should ... a diseased organism so that they can address deficiencies to ... to work, foreign (or synthetic) DNA must be introduced into ...
... the interaction of genes and environment in the ... King,s College London, has been awarded the Mortimer ... Developmental Psychobiology. Presented jointly by the Sackler Institute ... and the Sackler Institute for Developmental Psychobiology at ...
Cached Biology News:MNI researchers locate neurological basis of depression following sports concussion 2Cells get sprayed 2Research pioneer in the developmental origins of psychiatric illness is awarded the Sackler prize 2
MHC Volumes 1 & 2...
BD IMagnet 1 each...
Vertical Rack (five box vapor phase rack), includes 2.0" (5.1cm) boxes...
... M.W. Turner (1997). • This book ... in the production of high-quality antibodies, ... the standardisation of antibodies and antigens, ... systems, enzyme immunoassays for detecting cell-surface ...
Biology Products: