Navigation Links
Scientists fix bugs in our understanding of evolution
Date:6/19/2008

What makes a human different from a chimp? Researchers from the European Molecular Biology Laboratory's European Bioinformatics Institute [EMBL-EBI] have come one important step closer to answering such evolutionary questions correctly. In the current issue of Science they uncover systematic errors in existing methods that compare genetic sequences of different species to learn about their evolutionary relationships. They present a new computational tool that avoids these errors and provides accurate insights into the evolution of DNA and protein sequences. The results challenge our understanding of how evolution happens and suggest that sequence turnover is much more common than assumed.

"Evolution is happening so slowly that we cannot study it by simply watching it. That's why we learn about the relationships between species and the course and mechanism of evolution by comparing genetic sequences," says Nick Goldman, group leader at EMBL-EBI.

The four letter code that constitutes the DNA of all living things changes over time; for example individual or several letters can be copied incorrectly [substitution], lost [deletion] or gained [insertion]. Such changes can lead to functional and structural changes in genes and proteins and ultimately to the formation of new species. Reconstructing the history of these mutation events reveals the course of evolution.

A comparison of multiple sequences starts with their alignment. Characters in different sequences that share common ancestry are matched and gains and losses of characters are marked as gaps. Since this procedure is computationally heavy, multiple alignments are often built progressively from several pairwise alignments. It is impossible, however, to judge if a length difference between two sequences is a deletion in one or an insertion in the other sequence. For correct alignment of multiple sequences, distinguishing between these two events is crucial. Existing met
'/>"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
49-622-138-7452
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Ten Latin American Scientists Named 2008 Pew Fellows in the Biomedical Sciences
2. Israeli Scientists Recipients of 2008 International Adult Stem Cell Award
3. Weizmann Institute scientists create new nanotube structures
4. Abbott Scientists Present a New Approach for Treating Attention-Deficit Hyperactivity Disorder
5. Leading Overseas Scientists Establish High-Tech Bio-Pharmaceutical Enterprise in Changzhou
6. Scientists call for more access to biotech crop data
7. Scientists develop strategy to rapidly describe outbreak strains with next-generation DNA sequencing
8. Boehringer Ingelheim and BioSpace Search for Scientists at Career Fair in Boston, Massachusetts
9. Project Mind Survey of Israeli Ph.D. Scientists Favors a New Standard of Creativity in Science
10. When it Comes to Going Green, These N.C. Scientists are Singing the Blues
11. International team of scientists discover clue to delay of life on Earth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists fix bugs in our understanding of evolution
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, Inc., the ... relaunch of his highly informative blog, now named Stem Cells ... are Stem Cells ?” Dr. Harman’s purpose for blogging ... basics of stem cell therapy so that pet owners can ... when considering regenerative medicine. , A veterinarian by trade, Dr. ...
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
(Date:7/10/2014)... DUBLIN , July 10, 2014 ... the addition of the "International Photonic Integrated ... - Forecasts to 2019" report to their ... The concept of photonic integration traces ... twentieth century. The promise of photonic integration went ...
(Date:7/10/2014)... 17, 2014 Using microscopic polymer light resonators ... researchers at MIT,s Quantum Photonics Laboratory have developed ... the parts-per-billion range. Optical sensors are ideal for ... signal-to-noise ratio, compact, lightweight nature, and immunity to ... had been developed before, the MIT team conceived ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2
... Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) and ... how the botulinum neurotoxin, a potential bioterrorism agent, survives ... through the human body. Their study, published February 24 ... of a neurotoxin together with its bodyguard, a protein ...
... The condensation of water is crucial to the operation of ... they are fueled by coal, natural gas or nuclear fuel. ... salty or brackish water. But there are still large gaps ... the surfaces used to turn steam back into water in ...
... 23, 2012 Springboard Enterprises has over a ... by women to potential investors and corporate partners. ... community-driven accelerator designed to fast track the growth ... healthcare IT companies from around the world. The ...
Cached Biology Technology:Disarming the botulinum neurotoxin 2Disarming the botulinum neurotoxin 3Making droplets drop faster 2Making droplets drop faster 3The Search Is On for the Next Big Life Science Innovation 2The Search Is On for the Next Big Life Science Innovation 3
(Date:7/11/2014)... from Salk Institute for Biological Studies, BGI, and ... safety and reliability of the existing targeted gene ... TALEN-HDAdV, which could significantly increased gene-correction efficiency in ... published online in Cell Stell Cell ... gene therapy. , The combination of stem cells ...
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
(Date:7/11/2014)... has demonstrated that transplantation of mesenchymal stem cells can ... mouse models of Alzheimer,s disease (AD) and improve tissue ... Few studies are reported on the therapeutic effect of ... and on the effect on oxidative injury and neurogenesis ... and her team, School of Life Sciences, Tsinghua University, ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2Molecular snapshots of oxygen formation in photosynthesis 2
... Aware, Inc. (Nasdaq: AWRE ), a leading technology ... scheduled a conference call to discuss the company,s operating results ... February 3, 2011, at 5:00 p.m. Eastern Time. President and ... earnings conference call. This call is being webcast ...
... HARBIN, China, Feb. 1, 2011/PRNewswire-Asia-FirstCall/ -- Weikang Bio-Technology ... WKBT ) ("Weikang" or the "Company"), a leading ... (TCM), Western prescription and OTC pharmaceuticals and other ... of China, today announced the completion of its ...
... SANDY, Utah, Feb. 9, 2011 Qqest and M2SYS ... announced a partnership that allows Qqest to offer TimeForce ... features of biometric identification technology at their PC. ... biometric platform technology to seamlessly interface with Qqest,s ...
Cached Biology News:Aware, Inc. Announces Q4 and FY2010 Earnings Conference Call 2Weikang Bio-Technology Announces Completion of $5.0 Million Private Placement 2Weikang Bio-Technology Announces Completion of $5.0 Million Private Placement 3Qqest Teams Up With M2SYS to Add Biometric Technology at the Desktop to TimeForce Time and Attendance System 2Qqest Teams Up With M2SYS to Add Biometric Technology at the Desktop to TimeForce Time and Attendance System 3
... Jouan RC10 series of vacuum concentrators/centrifugal evaporators ... features allied to rapid and safe concentration ... be combined with oil-free or high vacuum ... a wide selection of rotors (eliminating sample ...
... is Thermo Electron's most advanced personal gradient ... to use sophisticated onboard software and a ... to offer performance, accuracy and simplicity in ... of customer driven features built up on ...
Carrier Serum...
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
Biology Products: