There's no question, drugs work in treating disease. But can they work better, and safer?
In recent years, researchers have grappled with the challenge of administering therapeutics in a way that boosts their effectiveness by targeting specific cells in the body while minimizing their potential damage to healthy tissue.
The development of new methods that use engineered nanomaterials to transport drugs and release them directly into cells holds great potential in this area. And while several such drug-delivery systems including some that use dendrimers, liposomes or polyethylene glycol have won approval for clinical use, they have been hampered by size limitations and ineffectiveness in accurately targeting tissues.
Now, researchers at UCLA have developed a new and potentially far more effective means of targeted drug delivery using nanotechnology.
In a study to be published in the May 23 print issue of the journal Small (and currently available online), they demonstrate the ability to package drug-loaded "nanodisks" into vault nanoparticles, naturally occurring nanoscale capsules that have been engineered for therapeutic drug delivery. The study represents the first example of using vaults toward this goal.
The UCLA research team was led by Leonard H. Rome and included his colleagues Daniel C. Buehler and Valerie Kickhoefer from the UCLA Department of Biological Chemistry; Daniel B. Toso and Z. Hong Zhou from the UCLA Department of Microbiology, Immunology and Molecular Genetics; and the California NanoSystems Institute (CNSI) at UCLA.
Vault nanoparticles are found in the cytoplasm of all mammalian cells and are one of the largest known ribonucleoprotein complexes in the sub-100-nanometer range. A vault is essentially barrel-shaped nanocapsule with a large, hollow interior properties that make them ripe for engineering into a drug-delivery vehicles. The ability to encapsulate small-mole
|Contact: Jennifer Marcus|
University of California - Los Angeles