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Scientists develop tools to make more complex biological machines from yeast
Date:3/20/2012

Scientists are one step closer to making more complex microscopic biological machines, following improvements in the way that they can "re-wire" DNA in yeast, according to research published today in the journal PLoS ONE.

The researchers, from Imperial College London, have demonstrated a way of creating a new type of biological "wire", using proteins that interact with DNA and behave like wires in electronic circuitry. The scientists say the advantage of their new biological wire is that it can be re-engineered over and over again to create potentially billions of connections between DNA components. Previously, scientists have had a limited number of "wires" available with which to link DNA components in biological machines, restricting the complexity that could be achieved.

The team has also developed more of the fundamental DNA components, called "promoters", which are needed for re-programming yeast to perform different tasks. Scientists currently have a very limited catalogue of components from which to engineer biological machines. By enlarging the components pool and making it freely available to the scientific community via rapid Open Access publication, the team in today's study aims to spur on development in the field of synthetic biology.

Future applications of this work could include tiny yeast-based machines that can be dropped into water supplies to detect contaminants, and yeast that records environmental conditions during the manufacture of biofuels to determine if improvements can be made to the production process.

Dr Tom Ellis, senior author of the paper from the Centre for Synthetic Biology and Innovation and the Department of Bioengineering at Imperial College London, says: "From viticulture to making bread, humans have been working with yeast for thousands of years to enhance society. Excitingly, our work is taking us closer to developing more complex biological machines with yeast. These tiny b
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Contact: Colin Smith
cd.smith@imperial.ac.uk
44-207-594-6712
Imperial College London
Source:Eurekalert

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