Navigation Links
Scientists develop new technologies for understanding bacterial infections
Date:8/29/2011

mising drugs fail to live up to expectations.

To begin bridging this gap in our understanding, Professors Brady and Virji teamed up with Dr Massimo Antognozzi from the University's School of Physics, whose group have been developing a novel form of atomic force microscope, termed the lateral molecular force microscope (LMFM).

Together, they have evolved the design of the LMFM microscope to optimise its ability to measure biological phenomena such as changes in UspA1 directly at the Moraxella cell surface. The LMFM differs from more conventional atomic force microscopes in tapping samples (in this case, individual cells) against an extremely fine lever, equivalent to the stylus of a record player, rather than moving the lever as is usually the case. Fabrication of extremely thin but stiff cantilevers together with exceptionally fine motor movements and a specialised visualisation system have all been combined in the device to tremendous effect. The sensitivity achieved has been further enhanced by its location within the extremely low vibration environment provided within the University's innovative Nanoscience and Quantum Information building. The result has been a machine that can measure exquisitely fine molecular changes and forces in individual molecules directly on a living cell surface.

In the Moraxella study, this development has enabled the research team to correlate intricate, atomic level detail of UspA1 obtained by X-ray crystallography of isolated fragments of the protein with delicate and previously unobservable physical changes of the bacterial cell as it binds to and infects its target human cells.

Professor Brady said: "The findings have triggered the development of a novel technology that promises to open up a new approach for studying molecular medicine. This breakthrough will undoubtedly prove equally useful for the study of many other biological processes directly within their cellular environment, something
'/>"/>

Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-077-761-70238
University of Bristol
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Syngene Expands Ongoing Relationship with CAS to Provide SciFinder® to All Its Scientists
2. A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins
3. Nottingham scientists pioneer new method for nanoribbon production
4. Scientists pinpoint river flow associated with cholera outbreaks, not just global warming
5. Scientists take a step towards developing better vaccines for bluetongue
6. Rice scientists build battery in a nanowire
7. Comprendia and New England Biolabs Connect Epigenetics Scientists with New Social Media Application
8. Scientists shed light on the private lives of electrons
9. Scientists hope to get glimpse of adolescent universe from revolutionary instrument-on-a-chip
10. Berkeley scientists pioneer nanoscale nuclear materials testing capability
11. N.C. Scientists Plant Plants to be Manufacturing Plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... , Aug. 3, 2015  ArroGen Group, an ... new Fingerprint Molecular Identification™ (FMID) technology Aug. 2-8 ... in Sacramento, Calif. ... will enable law enforcement agents, district attorneys and ... criminal suspects. By analyzing chemical residues ...
(Date:8/3/2015)... Ga. , Aug. 3, 2015  MiMedx Group, ... company utilizing human amniotic tissue and patent-protected processes to ... Wound Care, Surgical, Orthopedic, Spine, Sports Medicine, Ophthalmic and ... present at the 35 th Annual Canaccord|Genuity Growth ... H. "Pete" Petit, Chairman and CEO, William C. ...
(Date:8/3/2015)... Aug. 3, 2015  Merck KGaA, Darmstadt, ... top-quality high-tech products in the healthcare, life science and ... company Nano-C, their development and launch of promising new ... (OPV). Merck KGaA, Darmstadt, Germany , ... OPV sector. Novel derivatives: highly stable, easy ...
(Date:8/3/2015)... Medical, Inc. (Nasdaq: AEMD ), the pioneer in ... announced that it will host its First Quarter Fiscal ... 13, 2015 at 4:30 p.m. Eastern Time. ... fiscal 2016 first quarter results.  A recorded version of ... the call at the Investor Relations portion of the ...
Breaking Biology Technology:ArroGen Previews New Fingerprint Molecular Identification Technology 2MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 3Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 4Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2
... , ... , , , Quantitative ... procedure in many laboratories.,Protocols are available for various applications,especially in ... division by exogenous factors,stimulation/inhibition by cytokines, development of,serum-free media, influence ...
... , , , ... , , , , ... the first companies,to offer a nonradioactive technology allowing customers,to move away ... the,increasing availability of many different competitor,products and quantitative PCR-based technologies, the,DIG ...
... , , ... , , , Since the ... of foreign genes,appeared a few years ago, RNAi has become a ... short double-stranded RNAs that are,homologous to the suppressed gene. These small ...
Cached Biology Technology:Quantitative Measurement of Cell Proliferation,Using the BrdU ELISA: A Comparison,Between Colorimetric and Chemiluminescent Detection 2Quantitative Measurement of Cell Proliferation,Using the BrdU ELISA: A Comparison,Between Colorimetric and Chemiluminescent Detection 3Quantitative Measurement of Cell Proliferation,Using the BrdU ELISA: A Comparison,Between Colorimetric and Chemiluminescent Detection 4Quantitative Measurement of Cell Proliferation,Using the BrdU ELISA: A Comparison,Between Colorimetric and Chemiluminescent Detection 5Quantitative Measurement of Cell Proliferation,Using the BrdU ELISA: A Comparison,Between Colorimetric and Chemiluminescent Detection 6The DIG System Nonradioactive and,Highly Sensitive Detection of Nucleic Acids 2The DIG System Nonradioactive and,Highly Sensitive Detection of Nucleic Acids 3The DIG System Nonradioactive and,Highly Sensitive Detection of Nucleic Acids 4The DIG System Nonradioactive and,Highly Sensitive Detection of Nucleic Acids 5Quantification of siRNA Silencing Efficiency,Using the LightCycler System 2Quantification of siRNA Silencing Efficiency,Using the LightCycler System 3Quantification of siRNA Silencing Efficiency,Using the LightCycler System 4Quantification of siRNA Silencing Efficiency,Using the LightCycler System 5
(Date:8/4/2015)... Aug. 4, 2015  AMRI (NASDAQ: AMRI ) today reported ... 2015. Highlights: , Second quarter contract revenue ... 2014 , Adjusted contract margins of ... $0.22, including a $0.05 decrease in EPS from royalties in the ... million "We are very pleased to present another ...
(Date:7/31/2015)... China , 31 de julho de 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) será realizada pela BGI de 22-25 ... . A conferência está celebrando seu ... em 2006, a ICG se tornou uma das reuniões ... um dos encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... --NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market and creator of the Wocket® smart ... for ELECTRONIC CRYPTO-CURRENCY MANAGEMENT METHOD AND SYSTEM ... crypto-currencies such as Bitcoin into the consumer market of ... manage all payments.  The technology manages ...
Breaking Biology News(10 mins):AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4
... involved in many forms of leukemia and lymphoma is ... our genes by affecting whole swaths of chromosomes in ... issue of Nature Genetics and appearing online August 6. ... known as JAK/STAT focused on complex questions involving the ...
... Somerville of the Carnegie Institution and Stanford University, explained ... and achievable to reduce costs and multiply current levels ... Somerville presented his talk, "Bioenergy: The 21st Century Challenge ... American Society of Plant Biologists (ASPB) today (4:30 p.m. ...
... is a particular place inside a cell where they carry ... from the Charité Berlin, the University of Heidelberg, and the ... been able to visualize the structure of a "molecular machine" ... analysis. , This "machine" is made up of a ...
Cached Biology News:Loosen up, DNA: Leukemia gene changes genetic packaging 2Loosen up, DNA: Leukemia gene changes genetic packaging 3Loosen up, DNA: Leukemia gene changes genetic packaging 4Scientific issues associated with carbon-neutral energy sources such as cellulosic ethanol 2The molecular post office inside the cell 2
... series embodies all aspects of classical microscopy ... powerful Achromatic Super Contrast (ASC) objectives coupled ... this microscope combines flexibility and professional microscopy ... B1 series, the DM-B1 steps into the ...
... gel stain is a sensitive nucleic ... when bound to RNA and low background ... with either formaldehyde/agarose or polyacrylamide gels using ... 500 µL unit size (S-7564) and 1mL ...
... and reports the data from any one of ... chart recorder. The final data is sent from ... selection is automatic for Systolic, Mean, Heart Rate ... user is always in the position to override ...
... HT is taking automated patch clamping to a ... ability to generate thousands of high quality data ... paradigms in ion channel drug discovery and safety ... quality afforded by conventional patch clamping can now ...
Biology Products: