Navigation Links
Scientists develop new technologies for understanding bacterial infections
Date:8/29/2011

Understanding how bacteria infect cells is crucial to preventing countless human diseases. In a recent breakthrough, scientists from the University of Bristol have discovered a new approach for studying molecules within their natural environment, opening the door to understanding the complexity of how bacteria infect people.

The research, led by a team of biochemists, microbiologists and physicists and published in the Proceedings of the National Academy of Sciences (PNAS), provides an unprecedented level of detail of the consequences of a bacterium approaching another cell, directly in situ.

Until now, traditional approaches to understanding infection have focused on either studies of the cells involved or dissection of individual molecules present within the cells. Leo Brady, Professor of Biochemistry and Mumtaz Virji, Professor of Molecular Microbiology, who led the research, have developed a novel method for bridging these, until now, separate approaches.

The team studied the common bacterium Moraxella catarrhalis, which causes middle ear infections in young children, and is a major cause of morbidity in those with heart disease. For many years, scientists approached this problem from the molecular medicine approach through isolating and studying proteins from the Moraxella cell surface that initiate infection.

From these detailed studies the team have been able to develop an overview of one of the key proteins, called UspA1. However, as with the vast majority of molecular medicine approaches, this model has been based on studies of the UspA1 protein in isolation, rather than in its natural setting on the bacterium surface. A common worry for many biomedical scientists is how such understanding translates into the reality of these tiny molecules when they are part of a much larger cell. Understanding the increased complexity of individual molecules within the cellular mle is crucial to understanding why many pro
'/>"/>

Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-077-761-70238
University of Bristol
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Syngene Expands Ongoing Relationship with CAS to Provide SciFinder® to All Its Scientists
2. A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins
3. Nottingham scientists pioneer new method for nanoribbon production
4. Scientists pinpoint river flow associated with cholera outbreaks, not just global warming
5. Scientists take a step towards developing better vaccines for bluetongue
6. Rice scientists build battery in a nanowire
7. Comprendia and New England Biolabs Connect Epigenetics Scientists with New Social Media Application
8. Scientists shed light on the private lives of electrons
9. Scientists hope to get glimpse of adolescent universe from revolutionary instrument-on-a-chip
10. Berkeley scientists pioneer nanoscale nuclear materials testing capability
11. N.C. Scientists Plant Plants to be Manufacturing Plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... BOULDER, Colo. , Jan. 23, 2015  Array BioPharma ... it has reached a definitive agreement with Novartis Pharma ... BRAF inhibitor currently in Phase 3 development.  This agreement is ... and GlaxoSmithKline PLC (GSK) on April 22, 2014, which are ...
(Date:1/22/2015)... January 22, 2015 GEA Niro Soavi ... top laboratory homogenizer, the PandaPLUS 2000, which is ideal ... , and cell disruption . This compact laboratory ... fruit juices, liquid food, food additives and ingredients as ...
(Date:1/22/2015)... 2015 Crystal Diagnostics (CDx) Xpress System, a ... received AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. ... referred to as STEC or the “Big-6”) as well as ... (cfu) per 325 g of raw ground beef and raw ...
(Date:1/22/2015)... Selexis SA, a serial innovation company with ... used for drug discovery to commercial manufacturing, announced today ... Next-Generation Sequencing (NGS) data packages. The NGS analysis ... ensuring the integrity of the gene, validation of the ...
Breaking Biology Technology:Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 2Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 3Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 4Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 5Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 6Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 7GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2
... LMNX ) today announced that management will ... Growth Conference to be held,September 20, 2007, in ... Balthrop, president and chief,executive officer, and Harriss T. ... Eastern time on Thursday, September 20, 2007. The,presentation ...
... ... Pathogens, PHILADELPHIA, Sept. ... agreement with the Defense,Threat Reduction Agency (DTRA) of the U.S. Department ... targeting both Gram,negative biothreats and conventional Gram negative hospital pathogens. The,agreement ...
... Intra-Cellular Therapies today,announced it has developed a novel ... treatment of female sexual dysfunction (FSD). These,small molecule ... neuronal activity in selected regions of the brain. ... the treatment of hypoactive,sexual desire disorder (HSDD), a ...
Cached Biology Technology:Luminex Corporation to Present at America's Growth Capital Emerging Growth Conference 2GlaxoSmithKline Awarded U.S. Department of Defense Contract to Pursue Novel Antibacterial Research Program 2GlaxoSmithKline Awarded U.S. Department of Defense Contract to Pursue Novel Antibacterial Research Program 3Intra-Cellular Therapies Provides Overview of its Proprietary Portfolio of Compounds for the Treatment of Female Sexual Dysfunction (FSD) 2Intra-Cellular Therapies Provides Overview of its Proprietary Portfolio of Compounds for the Treatment of Female Sexual Dysfunction (FSD) 3
(Date:12/22/2014)... Conn. , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market, ... Apollo Robbins for the 2015 International CES debut ... Apollo Robbins will be at the NXT-ID booth January ...
(Date:12/19/2014)... Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has announced the ... Apple/AuthenTec TMDR92 & Sapphire - Technology Report" report ... Following the acquisition of AuthenTec in ... the iPhone 5S. It is currently the only device ...
(Date:12/19/2014)... , Dec. 18, 2014   LaunchKey , the first ... post-password and Internet of Things era, today announced the ... venture round was led by Metamorphic Ventures with participation ... Partners, VegasTechFund, and others.  LaunchKey has raised $4 million ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... Children,s Hospital of Philadelphia has announced the establishment of ... A ceremony on Feb. 15 at the Hospital,s ... the first holder of the chair, pediatric immunologist Jordan ... will allow Dr. Orange to break new ground in ...
... brain are characteristic features of Alzheimer disease. The effect ... plays a central role in learning and memory, is ... of tau protein is largely eliminated when the corresponding ... Planck Research Unit for Structural Molecular Biology at DESY ...
... available in Spanish . Tomatoes spend ... estimated 20 percent are lost to spoilage, according to the ... Research Service (ARS) are working with colleagues at Purdue University ... may lead to tomatoes that taste better and are more ...
Cached Biology News:Modell Chair in Pediatric Immunology established 2Tau-induced memory loss in Alzheimer's mice is reversible 2Tau-induced memory loss in Alzheimer's mice is reversible 3Finding a way to extend tomato shelf-life 2
Human Serpin A3 MAb (Clone 213907)...
Recombinant Ovine (Sheep) Growth Hormone, Ultra Pure...
Human SorCS1 Affinity Purified Polyclonal Ab Protein Family: Neurotrophins...
Viral CCI Biotinylated Affinity Purified PAb...
Biology Products: