Navigation Links
Scientists develop new technologies for understanding bacterial infections
Date:8/29/2011

Understanding how bacteria infect cells is crucial to preventing countless human diseases. In a recent breakthrough, scientists from the University of Bristol have discovered a new approach for studying molecules within their natural environment, opening the door to understanding the complexity of how bacteria infect people.

The research, led by a team of biochemists, microbiologists and physicists and published in the Proceedings of the National Academy of Sciences (PNAS), provides an unprecedented level of detail of the consequences of a bacterium approaching another cell, directly in situ.

Until now, traditional approaches to understanding infection have focused on either studies of the cells involved or dissection of individual molecules present within the cells. Leo Brady, Professor of Biochemistry and Mumtaz Virji, Professor of Molecular Microbiology, who led the research, have developed a novel method for bridging these, until now, separate approaches.

The team studied the common bacterium Moraxella catarrhalis, which causes middle ear infections in young children, and is a major cause of morbidity in those with heart disease. For many years, scientists approached this problem from the molecular medicine approach through isolating and studying proteins from the Moraxella cell surface that initiate infection.

From these detailed studies the team have been able to develop an overview of one of the key proteins, called UspA1. However, as with the vast majority of molecular medicine approaches, this model has been based on studies of the UspA1 protein in isolation, rather than in its natural setting on the bacterium surface. A common worry for many biomedical scientists is how such understanding translates into the reality of these tiny molecules when they are part of a much larger cell. Understanding the increased complexity of individual molecules within the cellular mle is crucial to understanding why many pro
'/>"/>

Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-077-761-70238
University of Bristol
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Syngene Expands Ongoing Relationship with CAS to Provide SciFinder® to All Its Scientists
2. A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins
3. Nottingham scientists pioneer new method for nanoribbon production
4. Scientists pinpoint river flow associated with cholera outbreaks, not just global warming
5. Scientists take a step towards developing better vaccines for bluetongue
6. Rice scientists build battery in a nanowire
7. Comprendia and New England Biolabs Connect Epigenetics Scientists with New Social Media Application
8. Scientists shed light on the private lives of electrons
9. Scientists hope to get glimpse of adolescent universe from revolutionary instrument-on-a-chip
10. Berkeley scientists pioneer nanoscale nuclear materials testing capability
11. N.C. Scientists Plant Plants to be Manufacturing Plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)...   ISN has released its third annual ... publication series. With data aggregated from over eight ... within its online contractor management platform, ISNetworld, this three-part ... (KPI) statistics. The Contractor ... is available in two industry specific volumes: Oil ...
(Date:12/17/2014)... December 17, 2014 Based on ... overall surgical imaging market is dominated by four ... surgical imaging market. These players include GE Healthcare ... Imaging (Germany). , Full Report Copy at ... GE Healthcare can be attributed to its strong ...
(Date:12/17/2014)... 17, 2014 Ipsen Biopharmaceuticals, Inc., ... ADR: IPSEY), today announced that Somatuline® ... Somatuline®) was approved by the U.S. Food and ... neuroendocrine tumors (GEP-NETs) in adult patients with unresectable, ... disease to improve progression-free survival (PFS). , “The ...
(Date:12/17/2014)... Xeno Diagnostics has again received an ... COLA inspection. Xeno has met all criteria for ... organization. Accreditation is earned only by laboratories that ... demonstrate continued accuracy in the performance of proficiency ... , While the Laboratory Excellence award ...
Breaking Biology Technology:ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 8Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2
... JACKSONVILLE, Fla., Oct. 4, 2011 MSC Care ... and services to post-discharge and post-injury workers, compensation ... Integrated Healthcare Services, a national company also focused ... unique and comprehensive surgical implant cost management solution, ...
... NeoStem, Inc. (NYSE Amex: NBS ) ("NeoStem" ... on cell-based therapeutic development, today announced that the Company and ... at three upcoming October conferences: the 2011 World Stem Cell ... Bioprocessing. 2011 World Stem Cell Summit ...
... Sequenom, Inc. (NASDAQ: SQNM ), a ... announced the launch of its iPLEX ADME PGx panel ... absorption, distribution, metabolism, and excretion (ADME). This Research Use ... nucleotide polymorphisms (SNP), insertions and deletions (INDELS) and copy ...
Cached Biology Technology:MSC to Offer Surgical Implant Cost Management Solution through Acquisition of Integrated Healthcare Services 2NeoStem Announces Participation in Multiple October Conferences 2NeoStem Announces Participation in Multiple October Conferences 3NeoStem Announces Participation in Multiple October Conferences 4Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 2Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 3
(Date:12/17/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor ... http://photos.prnewswire.com/prnh/20130307/600769 ... the iPhone 5S, Samsung introduces for the first ... The Galaxy S5 home button presents an ...
(Date:12/17/2014)... DENVER , Dec. 16, 2014  Automation ... is this more evident than at international borders. ... secure document scanners have allowed veteran travelers to ... Automated Passport Control (APC) Kiosks at an increasing ... the globe. According to ...
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014 /PRNewswire/ ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ... Adding functional endpoints to toxicology studies ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... at a pro-inflammatory signaling molecule involved in immune ... what they are doing" in creating drugs based ... in the Oct. 1 issue of the Journal ... at Urbana-Champaign unveiled the crystal structure of mouse ...
... project website , The annual Educational Technology ... been granted to the project 'Virtual microscopy as a ... the university. The awarded project utilizes advanced digital imaging ... specimens over the internet. , 'Virtual specimens' incorporated ...
... additional insight into the evolutionary process by examining ... New York University Biology Professor Richard Borowsky, examined ... albinism in both populations was linked to Oca2--a ... form of albinism in humans. They observed different ...
Cached Biology News:Molecular research suggest shift needed in how some drugs are created 2Genetic analysis of cavefish reveals more about evolution 2
Rat Dermal Fibroblasts (RDF) (>500,000 cells)...
...
... System is a compact, versatile & modular instrument ... purposes including: Intracellular, Extracellular, Transducer & Multi-channel ... NeuroLog Case & Power Supply unit (NL900D) forms ... are not only powered by this unit, but ...
37-1A9...
Biology Products: