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Scientists defuse the 'Vietnam time bomb'
Date:11/10/2011

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"This disease is an everyday reality for many people living in the endemic areas and our findings will allow us to test if an inactivated toxin might be effective as a component of a vaccine," says Professor Rick Titball, a member of the team from the University of Exeter.

The delayed action of the bacteria has led to it being dubbed the 'Vietnam time bomb' following the recognition that many US military personnel who served in Vietnam have been infected. "Now that we know of the existence of this toxin it opens up opportunities for the development of novel drugs that could block its effects," says University of Sheffield Professor, Stuart Wilson.

The study involved a consortium of UK scientists from the University of Sheffield, the University of Exeter, Diamond Light Source and the Defence Science and Technology Laboratory at Porton Down. European and international partners included: the European Synchrotron Radiation Facility (ESRF) in Grenoble, France; Universiti Kebangsaan Malaysia; the Malaysia Genome Institute; DSO National Laboratories, Singapore, and the Genome Institute of Singapore.

Kevin van Cauter, HE Advisor with the British Council commented "We are thrilled that PMI2 funding supported this international collaboration and are excited by the potential impact of the work."

These groups now plan to seek funding to continue the work and investigate potential applications of the toxin to fight other diseases, such as cancer, where it might usefully be employed in targeted therapies to prevent the proliferation of cancer cells.


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Contact: Clare Elsley
clare@campuspr.co.uk
44-113-357-2102
University of Sheffield
Source:Eurekalert

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