Navigation Links
Scientists defuse the 'Vietnam time bomb'
Date:11/10/2011

A key mechanism by which a bacterial pathogen causes the deadly tropical disease melioidosis has been discovered by an international team of scientists.

The findings are published today in the journal Science and show how a toxin produced by the bacterium Burkholderia pseudomallei kills cells by preventing protein synthesis. The study, led by the University of Sheffield, paves the way for the development of novel therapies to combat the bacterium which infects millions of people across South East Asia and Northern Australia.

Using intense X-rays at Diamond Light Source, the UK's national synchrotron facility, and at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France, the research team solved the structure of a protein from Burkholderia, the function of which was initially unknown.

"The information gathered from the structure suggested that the protein was a previously unsuspected toxin and sparked a search for its mode of action. This eventually led to the discovery of how it prevents human cells from making proteins and helped us to understand how it causes cell death," says research lead Professor David Rice from the Department of Molecular Biology and Biotechnology at the University of Sheffield.

Melioidosis, along with HIV and tuberculosis, is one of the top three causes of death by infectious disease in parts of South East Asia and arises from infection by the bacterium which thrives in water and warm, moist soils and can enter the body through the lungs or through open wounds.

It causes either an acute form of the disease which presents immediately upon infection, or it can lay dormant in the body emerging many years, and often decades, later. In the acute form of the disease, even with a long course of treatment, mortality rates in endemic areas can be as high as 40 per cent. With a wide range of symptoms, melioidosis can be difficult to diagnose, hampering medical intervention
'/>"/>

Contact: Clare Elsley
clare@campuspr.co.uk
44-113-357-2102
University of Sheffield
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Scientists carve nanowires out of ultrananocrystalline diamond thin films
2. Berkeley Lab scientists develop new tool for the study of spatial patterns in living cells
3. Shaken, not stirred: Berkeley lab scientists spy molecular maneuvers
4. Using new technique, scientists uncover a delicate magnetic balance for superconductivity
5. Scientists create computing building blocks from bacteria and DNA
6. Scientists determine alternative insecticide dramatically reduces malaria transmission
7. Scientists take up golf to prove long-standing theory of cell stickiness
8. Sheffield scientists shine a light on the detection of bacterial infection
9. Scientists observe how superconducting nanowires lose resistance-free state
10. Controlling silicon evaporation allows scientists to boost graphene quality
11. Scientists utilize breath and sweat to detect trapped humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 Diagenode, Inc., a ... the Bioruptor® and complete solutions for epigenetics research, ... immunoprecipitation, alleviating the need for manual processing. The ... for ChIP of histones or transcription factors and ...
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... focused on advanced wound care, announces that AMNIOEXCEL® ... have been added to the Premier, Inc. Regenerative ... opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product lines, ...
(Date:12/24/2014)... Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade hypothermic storage and cryopreservation ... for cells and tissues  ("BioLife" or the "Company"), today announced ... on May 4, 2015 (the "Annual Meeting"). Because ...
(Date:12/24/2014)... Bethesda, MD (PRWEB) December 23, 2014 ... law H.R. 83, the Omnibus and Continuing Resolution Appropriations ... hydrocephalus a condition eligible to receive funding through the ... Department of Defense (DoD). The Hydrocephalus Association (HA), working ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... CLEVELAND, March 19, 2012 The nation,s first ... 21-22 in Cleveland.  MBEC offers a unique platform ... leaders to engage, network, collaborate and exchange ideas. ... Minorities represent less than 5 percent(1) of ...
... that the product contains L(+)-lactic acid, one of two forms ... two"isomers", L(+) and D(-), have different "optical activities", turning the ... Of course the capacity to alter the polarization, intensity or ... Light interacts in one way or another with all matter. ...
... ST. LOUIS, March 15, 2012 Sigma-Aldrich® Corporation (NASDAQ: ... its new facility in Wuxi, China, that will provide ... products to support the Company,s research and industrial customers ... China has invested heavily in industrial growth, and now ...
Cached Biology Technology:Minority Biomedical Entrepreneurship Conference 2Minority Biomedical Entrepreneurship Conference 3Designer lights from the physics lab 2Sigma-Aldrich Opens New Wuxi Packaging and Quality Control Facilities to Enhance Capabilities Serving China and Asia-Pacific Region 2Sigma-Aldrich Opens New Wuxi Packaging and Quality Control Facilities to Enhance Capabilities Serving China and Asia-Pacific Region 3
(Date:12/24/2014)... in December 2014, the 1U™ app has helped ... remember their usernames and passwords through replacing the antiquated system ... people who have struggled to remember usernames and passwords, ... on redefining identity, announced today that it is offering the ...
(Date:12/22/2014)... 22, 2014  The 2014 Holiday Season may be the ... Intelligence reports that the long anticipated floodgates for consumer ... demand for smart phones, tablets, and wearable mobile devices ... 2.5 billion users with nearly 4.8 billion biometric devices ...
(Date:12/19/2014)... 2014  23andMe, Inc., the leading personal genetics company, today announced ... genetic ancestry of individuals from across the United ... than four hundred years ago, the United States ... from different continents. This study illuminates how American history and ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... share a biological adaptation that enables them to thrive in ... pass on the trait appears to be linked to different ... Reserve University scientist and colleagues shows. The adaptation is ... level of hemoglobin, the oxygen-carrying protein in red blood cells. ...
... Notre Dame stream ecologist Gary Lamberti. If you,re catching ... strong salmon run, the stream fish brook trout, brown ... by the salmon. Research by Lamberti, professor and chair ... they travel upstream to spawn and die, carry industrial pollutants ...
... ESA joined international delegates in Doha, Qatar, to discuss how ... climate change and how this information is useful to ... talks and negotiations, the UN Climate Change Conference has entered ... Ministers of Environment. ,During the first week of the ,COP ...
Cached Biology News:Different genes behind same adaptation to thin air 2Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream 2Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream 3Climate - the hot topic in Doha 2
... SB3, Fully adjustable mixing angle, Variable speed, ... hold a number of different sized tubes, ... aerating cultures, keeping biological samples in suspension ... can be used in incubators up to ...
... 2 real-time PCR detection system uses a ... (470-505 nm) and two photomultiplier tubes for ... Opticon 2 system is built on an ... thermal gradient feature. This item includes the ...
... Multicolor capability allows detection of SYBR ... channel, and a range of fluorophores in ... VIC, and TAMRA for a multitude ... discrimination. DNA Engine thermal cycler offers precision ...
Fingerprinting II dimensioning techniques is an optional module that adds principal component analysis, multidimensional scaling, discriminant analysis and MANOVA, and self-organizing maps to the Fin...
Biology Products: