Navigation Links
Scientists create mammalian cells with single chromosome set
Date:9/7/2011

Researchers have created mammalian cells containing a single set of chromosomes for the first time in research funded by the Wellcome Trust and EMBO. The technique should allow scientists to better establish the relationships between genes and their function.

Mammal cells usually contain two sets of chromosomes one set inherited from the mother, one from the father. The genetic information contained in these chromosome sets helps determine how our bodies develop. Changes in this genetic code can lead to or increase the risk of developing disease.

To understand how our genes function, scientists manipulate the genes in animal models such as the fruit fly, zebrafish and mice and observe the effects of these changes. However, as each cell contains two copies of each chromosome, determining the link between a genetic change and its physical effect or 'phenotype' is immensely complex.

Now, in research published today in the journal Nature, Drs Anton Wutz and Martin Leeb from the Wellcome Trust Centre for Stem Cell Research at the University of Cambridge report a technique which enables them to create stem cells containing just a single set of chromosomes from an unfertilised mouse egg cell. The stem cells can be used to identify mutations in genes that affect the cells' behaviour in culture. In an additional step, the cells can potentially be implanted into the mouse for studying the change in organs and tissues.

The technique has previously been used in zebrafish, but this is the first time it has been successfully used to generate such mammalian stem cells.

Dr Wutz, a Wellcome Trust Senior Research Fellowship, explains: "These embryonic stem cells are much simpler than normal embryonic mammalian stem cells. Any genetic change we introduce to the single set of chromosomes will have an easy-to-determine effect. This will be useful for exploring in a systematic way the signalling mechanisms within cell and ho
'/>"/>

Contact: Craig Brierley
44-207-611-329
Wellcome Trust
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Clemson scientists put a (nano) spring in their step
2. City of Hope Helps KGI Launch New Management Training Program for Scientists
3. University of Pennsylvania scientists move optical computing closer to reality
4. Scientists grow nanonets able to snare added energy transfer
5. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
6. Scientists peel away the mystery behind golds catalytic prowess
7. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
8. Vermillion and Stanford Scientists Receive Best Research Award From the PAD Coalition
9. Brewing better beer: Scientists determine the genomic origins of lager yeasts
10. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
11. CU scientists create worlds thinnest balloon -- just one atom thick
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists create mammalian cells with single chromosome set
(Date:1/15/2014)... NY (PRWEB) January 15, 2014 The Microcompetition ... a major disease. One of these latent viruses is the ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory ... theory, a study found that RA patients have high concentrations ...
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... growth for Scottsdale’s Brain State Technologies®. They saw continued ... University Medical Center who were awarded a $1 million ... papers published in “Brain and Behavior” a peer reviewed ...
(Date:1/15/2014)... 15, 2014 AudioNotch is the internet's ... for the treatment of tinnitus. Patients listen to sound ... over a period of weeks to months, their tinnitus volume ... two forms: Notched Music and Notched White Noise. Now, AudioNotch ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 Date: ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, ... only national nonprofit organization solely dedicated to finding a cure ... those affected worldwide, will host its annual Crystal Ball on ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... ISELIN, N.J., Oct. 1 SyntheMed, Inc. (OTC,Bulletin ... development,and commercialization of anti-adhesion products and other surgical,implants, ... closing of a,private placement in which it received ... involved the issuance to investors of ten million ...
... Celsis Rapid Detection, a division of,Celsis International plc ... Sullivan,2008 North American Growth Strategy Leadership Award recipient ... and Release of,Pharmaceuticals., "The Celsis Rapid Detection ... pharmaceutical companies to significantly reduce,production cycle times in ...
... SoluLinK, Inc., a leader in,conjugation products and ... of its newest product, the One-Shot ChromaLink ... the components for the rapid,traceable biotinylation of ... sulfo-ChromaLink Biotin linker, a water-soluble, biotin labeling,reagent ...
Cached Biology Technology:SyntheMed Completes $4.0 Million Equity Placement 2Celsis Receives Frost & Sullivan 2008 Best Practices Award 2Celsis Receives Frost & Sullivan 2008 Best Practices Award 3SoluLinK Introduces New One-Shot ChromaLink(TM) Biotin Antibody Labeling Kit with Built-in Biotin Quantification. 2
(Date:4/23/2014)... NY. (Apr. 23 2014) A team ... stem cells (hNSCs) into the brains of nonhuman ... 22 and 24 months found that the hNSCs ... did not cause tumors. , The study will ... Cell Transplantation but is currently freely available ...
(Date:4/23/2014)... who have had a stroke, often suffer motor deficits ... study conducted in Taiwan, that will be published in ... is currently freely available on-line as an unedited early ... one group of stroke victims had their own peripheral ... and a similar group did not, those who received ...
(Date:4/23/2014)... TX (4/23/14) -- Researchers have found evidence of ... factors that increase aggressive behavior in children, especially ... not all children exposed to prenatal smoking will ... will not," said Brian Boutwell, Assistant Professor at ... and senior author on the study. "One ...
Breaking Biology News(10 mins):Study finds long-term survival of human neural stem cells transplanted into primate brain 2Autologous stem cell therapy improves motor function in chronic stroke victims 2Genetics risk, prenatal smoking may predict behavioral problems 2
... skin like a temporary tattoo, can alert marathoners, competitive bikers ... "hit the wall," scientists are reporting. The study, in ACS, ... of the sensor, which also could help soldiers and others ... monitor stamina and fitness. Joseph Wang and colleagues ...
... those painful lip blisters known as cold sores has an internal ... to literally blast its infectious DNA into human cells, scientists are ... the first in a human virus opens the door ... in the Journal of the American Chemical Society . ...
... MINNEAPOLIS/ST. PAUL (July 23, 2013) Mere months after ... the United States swine population, University of Minnesota researchers ... The first-of-its-kind test, which is available now, provides a ... U.S. PEDV strains. Characterized by acute diarrhea ...
Cached Biology News:U of M researchers unveil nation's first porcine virus rapid detection test 2
... The mycobacteria in ... cells to the injection site which enhances ... Freund's Adjuvant is used for the initial ... the subsequent boosts. Antigens (preferably in saline) ...
HiTrap Streptavidin HP, 5 x 1 ml. Category: Chromatography Systems & Accessories, Systems....
...
Request Info...
Biology Products: