Navigation Links
Scientists create colorful 'brainbow' images of the nervous system
Date:10/31/2007

ed fluorescent proteins. The researchers painstakingly assembled the Brainbow transgene from snippets of DNA, and inserted it into neuronal DNA. As they predicted, the cut-and-paste recombination occurred totally at random, in the process assigning scores of different colors to neurons. This variation makes neurons leap out from one another visually under ordinary confocal microscopy.

"The technique drives the cell to switch on fluorescent protein genes in neurons more or less at random," says Livet, a postdoctoral researcher in the Department of Molecular and Cellular Biology and Center for Brain Science who did much of the legwork behind Brainbow. "You can think of Brainbow almost like a slot machine in its generation of random outcomes, and Cre/lox is the hand pulling the lever over and over again."

Using Brainbow to look at mouse neural circuits over periods as long as 50 days, the Harvard researchers were able to observe some neural reorganization over time and to ascertain that Brainbow labeling is stable and long-lived. Livet, Sanes, Lichtman, and colleagues are now using Brainbow to scour the nervous system for new insights into its organization and function.

"We've already used Brainbow to take a first peek at the nervous system of mice, and we've observed some very interesting, and previously unrecognized, patterns of neuron arrangement," says Sanes, professor in the Department of Molecular and Cellular Biology and Center for Brain Science at Harvard. "As far as understanding what we're seeing, we've only just scratched the surface."


'/>"/>

Contact: Steve Bradt
steve_bradt@harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. UW computer scientists fighting computer virus "Cold War"
2. Scientists find way to make human collagen in lab
3. Wisconsin scientists to be recognized for innovative biofuel technology
4. UW-Madison scientists to mimic nature for newest cancer drugs
5. UW scientists study strange material with communications potential
6. Scientists find nanotech method for examining cells
7. UW space scientists use Keck telescope to study wild weather of Uranus
8. UW computer scientists tout achievements and explain industry shortcomings
9. Facing shortage of U.S. scientists, UW wants to boost math enrollment
10. UW-Madison scientists find a key to cell division
11. TIP/UW Scientists Provide Mars Rover Commentary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... 4, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ... independent team of researchers from South ... (TB4) plays an important role in accelerating the ... an experimental mouse model, by promoting blood vessel ... dermal tissue.  The research found that the underlying ...
(Date:5/4/2015)... primarily through a proprietary paraffin and stain additive, Ultralight ... detail than the industry standard. But because it ... it needed another medium to measure its detail. ... because it represents the highest standard of detail available. ... days of Ultralight Histology was to reverse engineer the ...
(Date:5/4/2015)... , May 4, 2015 China Cord ... "Company"), China,s leading provider of ... and stem cell storage services, today announced that the ... ("Golden Meditech"), a Hong Kong ... has entered into an agreement (the "Agreement") to purchase ...
(Date:5/4/2015)... 2015   Tocagen Inc. , a clinical-stage ... Tocagen,s ongoing investigational studies were presented at the 11 ... Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons ... in Washington, D.C. In ... with FDA and continues to advance towards initiation ...
Breaking Biology Technology:Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 2Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 3China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 2China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 2Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 4Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 5
... Colo., Jan. 26, 2011 LABS Inc., the premier ... announced that Kimberly Elliott has joined the Company as ... experience in the donor and tissue services industry. At ... to existing clientele, entering new markets and building national ...
... 26, 2011 Novel solutions to 21st century innovation ... annual executive education conference for female leaders in the ... The Women Innovate Conference will feature panels ... ranging from small start-ups to global corporations.  Together, the ...
... SG Biofuels , a bioenergy crop company using breeding ... formally launched business operations in Brazil and introduced Brazilian ... advisor for the market. Reinach will provide ... SG Biofuels Brasil, LTD, a subsidiary of SG Biofuels ...
Cached Biology Technology:Kimberly (Lewis) Elliott Joins LABS Inc. as Sales Manager 2KGI Hosts Fourth Annual Conference for Women in Life Science Industry 2KGI Hosts Fourth Annual Conference for Women in Life Science Industry 3SG Biofuels Launches Operations in Brazil; Appoints Fernando Reinach as Senior Advisor 2
(Date:3/31/2015)... 2015  Elephant Talk Communications Corp. (NYSE MKT: ETAK) ... Software Defined Network Architecture (ET Software DNA® 2.0) platforms ... approximately $20.4 million for the year ended December 31, ... the year ended December 31, 2013. ... completed its multi-year transition away from its legacy landline ...
(Date:3/30/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has ... Market in Automotive Sector 2014-2018" report to their ... Recognition market in Automotive Sector to grow at a ... Gesture recognition is the ability of a device to ... Gesture recognition technology can be 2D-based or 3D-based. It ...
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... of the "Global Iris Recognition Market 2015-2019" ... the Global Iris Recognition market to grow at a ... This report covers the present scenario and the ... the period 2015-2019. To calculate the market size, the ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... German . More than half of all people are ... might be located on their skin or mucous membranes or in ... be dangerous to patients whose immunological system has been weakened such ... penetrates into deeper layers of tissue and uses the blood system ...
... announced his intent to nominate mathematical epidemiologist Carlos Castillo-Chavez, ... on the National Medal of Science. The committee, ... the National Medal of Science, a presidential award established ... to individuals "deserving of special recognition by reason of ...
... 28, 2010 - Eurofins MWG Operon, an expert in next ... Roche GS Junior. The GS Junior is the optimum system ... only one eighth of the capacity of a GS FLX ... Illumina run. As a consequence, the GS Junior adds a ...
Cached Biology News:Tracking down pathogenic yeasts 2Tracking down pathogenic yeasts 3Obama to appoint ASU professor to national committee 2
Mouse monoclonal antibody to PDK2 - pyruvate dehydrogenase kinase, isoenzyme 2...
... expression of an N-terminal FLAG® fusion and ... marker from bicistronic mRNA. Two genes ... for transcription of a single message from ... for protein-protein interaction studies, multi-subunit proteins, and ...
Mouse monoclonal antibody raised against a partial recombinant CALCOCO2. NCBI Entrez Gene ID = CALCOCO2...
Mouse polyclonal antibody raised against a partial recombinant KCTD13. NCBI Entrez Gene ID = 253980...
Biology Products: