Navigation Links
Scientists achieve first rewire of genetic switches
Date:1/25/2010

Researchers in Manchester have successfully carried out the first rewire of genetic switches, creating what could be a vital tool for the development of new drugs and even future gene therapies.

A team of scientists from the School of Chemistry and the Manchester Interdisciplinary Biocentre (MIB) at The University of Manchester have found a way of hijacking so-called 'riboswitches' and directing gene activity.

Working within cells of bacteria, chemical biologist Professor Jason Micklefield and his team have rewired these genetic switches so they are no longer activated by small naturally occurring molecules found in cells but through the addition of a synthetic molecule.

The work builds on the recent discovery that these naturally occurring molecules can turn genes on and off by triggering riboswitches found within a large molecule called 'messenger RNA'.

The research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Selective Chemical Intervention in Biological Systems Initiative.

In the latest research, when Manchester researchers added synthetic molecules, they bound to the riboswitches and caused the genes to spark into life.

The findings are reported in the latest edition of Proceedings of the National Academy of Sciences (PNAS).

The Manchester team monitored how successfully they had re-wired the cells by observing the creation of a gene product that makes the cells glow green.

Dr Neil Dixon, a senior researcher in the team, said: "Being able to selectively activate and regulate genes could have tremendous impact in drug discovery and the emerging field of synthetic biology.

"This technology could be used to turn on and off important biological pathways and processes, leading to a deeper understanding of how cells function.

"The next big challenge is to apply this technology to study biological processes within human cells. This could allow us to discover more about our hugely complex biological selves."

The Manchester team is now working on ways to simultaneously activate and control multiple genes using these re-wired riboswitches.


'/>"/>

Contact: Alex Waddington
alex.waddington@manchester.ac.uk
01-612-758-387
University of Manchester
Source:Eurekalert

Related biology technology :

1. Gladstone scientists uncover potential mechanism of memory loss in Alzheimers disease
2. Three Studies by Independent Scientists Highlighting Pressure Cycling Technology (PCT) to be Presented this Week at the British Mass Spectrometry Societys 29th Annual Meeting
3. Social Network for Scientists Marks Ten Years Online
4. Scientists synthesize memory in yeast cells
5. Scientists synthesize memory in yeast cells
6. University of Leicester scientists discover technique to help friendly bacteria
7. Scientists discover how cancer may take hold
8. Yale scientists make 2 giant steps in advancement of quantum computing
9. New Scientists Boost Disease-based Research at Boston Biomedical Research Institute
10. Scientists say sabercat bit like a pussycat
11. New Corporate Website Launched - Focus on Life Scientists, Flow Cytometrists, & Clinicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... MONICA, Calif. , June 23, 2016  The Prostate Cancer Foundation ... pioneer increasingly precise treatments and faster cures for prostate cancer. Members of the ... institutions across 15 countries. Read More About the Class ... ... ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... OTTAWA, ON (PRWEB) , ... June 23, 2016 , ... ... former DNA Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA ... joining the STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
Breaking Biology Technology:
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
(Date:5/24/2016)... IRVINE, Calif. , May 24, 2016 Ampronix facilitates superior patient care ... LMD3251MT  3D medical LCD display is the latest premium product recently added to ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
Breaking Biology News(10 mins):