Navigation Links
Scientists achieve first rewire of genetic switches
Date:1/25/2010

Researchers in Manchester have successfully carried out the first rewire of genetic switches, creating what could be a vital tool for the development of new drugs and even future gene therapies.

A team of scientists from the School of Chemistry and the Manchester Interdisciplinary Biocentre (MIB) at The University of Manchester have found a way of hijacking so-called 'riboswitches' and directing gene activity.

Working within cells of bacteria, chemical biologist Professor Jason Micklefield and his team have rewired these genetic switches so they are no longer activated by small naturally occurring molecules found in cells but through the addition of a synthetic molecule.

The work builds on the recent discovery that these naturally occurring molecules can turn genes on and off by triggering riboswitches found within a large molecule called 'messenger RNA'.

The research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Selective Chemical Intervention in Biological Systems Initiative.

In the latest research, when Manchester researchers added synthetic molecules, they bound to the riboswitches and caused the genes to spark into life.

The findings are reported in the latest edition of Proceedings of the National Academy of Sciences (PNAS).

The Manchester team monitored how successfully they had re-wired the cells by observing the creation of a gene product that makes the cells glow green.

Dr Neil Dixon, a senior researcher in the team, said: "Being able to selectively activate and regulate genes could have tremendous impact in drug discovery and the emerging field of synthetic biology.

"This technology could be used to turn on and off important biological pathways and processes, leading to a deeper understanding of how cells function.

"The next big challenge is to apply this technology to study biological processes within human cells. This could allow us to discover more about our hugely complex biological selves."

The Manchester team is now working on ways to simultaneously activate and control multiple genes using these re-wired riboswitches.


'/>"/>

Contact: Alex Waddington
alex.waddington@manchester.ac.uk
01-612-758-387
University of Manchester
Source:Eurekalert

Related biology technology :

1. Gladstone scientists uncover potential mechanism of memory loss in Alzheimers disease
2. Three Studies by Independent Scientists Highlighting Pressure Cycling Technology (PCT) to be Presented this Week at the British Mass Spectrometry Societys 29th Annual Meeting
3. Social Network for Scientists Marks Ten Years Online
4. Scientists synthesize memory in yeast cells
5. Scientists synthesize memory in yeast cells
6. University of Leicester scientists discover technique to help friendly bacteria
7. Scientists discover how cancer may take hold
8. Yale scientists make 2 giant steps in advancement of quantum computing
9. New Scientists Boost Disease-based Research at Boston Biomedical Research Institute
10. Scientists say sabercat bit like a pussycat
11. New Corporate Website Launched - Focus on Life Scientists, Flow Cytometrists, & Clinicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... , ... April 21, 2017 , ... ... related applications were the focus of researchers, engineers, product developers, and industry suppliers ... Anaheim. , Sponsored by SPIE, the international society for optics and photonics ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... to nourishing a range of emerging bio and technology start-ups, is hosting “Celebration ... 2017. This double event will start with libations and networking at 3:30 p.m. ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... this new webinar will explore challenging patient cases when screening for direct oral ... there may be a need for bridging parental anticoagulation especially for those at ...
(Date:4/20/2017)... INDIANAPOLIS , April 20, 2017  Eli Lilly ... Phase 2 data evaluating galcanezumab for the prevention of ... meeting, which will take place April 22-28, 2017, in ... will present four abstracts at AAN, including safety and ... and factors associated with a reduction in monthly migraine ...
Breaking Biology Technology:
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market ... Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast ... from USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):