Navigation Links
Scientists achieve first rewire of genetic switches
Date:1/25/2010

Researchers in Manchester have successfully carried out the first rewire of genetic switches, creating what could be a vital tool for the development of new drugs and even future gene therapies.

A team of scientists from the School of Chemistry and the Manchester Interdisciplinary Biocentre (MIB) at The University of Manchester have found a way of hijacking so-called 'riboswitches' and directing gene activity.

Working within cells of bacteria, chemical biologist Professor Jason Micklefield and his team have rewired these genetic switches so they are no longer activated by small naturally occurring molecules found in cells but through the addition of a synthetic molecule.

The work builds on the recent discovery that these naturally occurring molecules can turn genes on and off by triggering riboswitches found within a large molecule called 'messenger RNA'.

The research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Selective Chemical Intervention in Biological Systems Initiative.

In the latest research, when Manchester researchers added synthetic molecules, they bound to the riboswitches and caused the genes to spark into life.

The findings are reported in the latest edition of Proceedings of the National Academy of Sciences (PNAS).

The Manchester team monitored how successfully they had re-wired the cells by observing the creation of a gene product that makes the cells glow green.

Dr Neil Dixon, a senior researcher in the team, said: "Being able to selectively activate and regulate genes could have tremendous impact in drug discovery and the emerging field of synthetic biology.

"This technology could be used to turn on and off important biological pathways and processes, leading to a deeper understanding of how cells function.

"The next big challenge is to apply this technology to study biological processes within human
'/>"/>

Contact: Alex Waddington
alex.waddington@manchester.ac.uk
01-612-758-387
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Gladstone scientists uncover potential mechanism of memory loss in Alzheimers disease
2. Three Studies by Independent Scientists Highlighting Pressure Cycling Technology (PCT) to be Presented this Week at the British Mass Spectrometry Societys 29th Annual Meeting
3. Social Network for Scientists Marks Ten Years Online
4. Scientists synthesize memory in yeast cells
5. Scientists synthesize memory in yeast cells
6. University of Leicester scientists discover technique to help friendly bacteria
7. Scientists discover how cancer may take hold
8. Yale scientists make 2 giant steps in advancement of quantum computing
9. New Scientists Boost Disease-based Research at Boston Biomedical Research Institute
10. Scientists say sabercat bit like a pussycat
11. New Corporate Website Launched - Focus on Life Scientists, Flow Cytometrists, & Clinicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2014)... China is increasingly being recognized as ... industry. Clinicaltrial.gov statistics highlight the popularity of China ... a high increase in infectious diseases; a rapid ... of patients and a track record of rapid ... also presents challenges for the clinical research industry ...
(Date:8/16/2014)... 2014 Firms in the ... and advisory services to businesses, government bodies and ... services are highly diverse as operators assist a ... from geological and geophysical consulting services to risk ... past five years, the recovery of the Canadian ...
(Date:8/16/2014)... have found a way to make atomic-force microscope probes ... as small as the weight of an individual virus. ... National University (ANU), hinges on using laser beams to ... , "The level of sensitivity achieved after cooling is ... a large virus that is 100 billion times lighter ...
(Date:8/15/2014)...   Hospira, Inc. (NYSE: HSP ... infusion technologies, today announced that the company will present ... Sept. 9, 2014, in New York ... at 11:45 a.m. Eastern time on Tuesday, Sept. 9, ... through a live audiocast accessible via the investor relations ...
Breaking Biology Technology:China – Land of Opportunities & Challenges for the Clinical Research Industry, New Webinar Hosted by Xtalks 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 3Laser makes microscopes way cooler 2
... Milwaukee, Wis. — A water main break Thursday ... disrupt water service Friday to 37 companies in the ... parks director of development said businesses in the incubator ... Mascari, whose office is located in the 137,000-square-foot Technology ...
... Madison, Wis. A professor who has worked for ... the lifespan of rhesus monkeys was featured in the MIT ... a colony of 78 monkeys at the University of Wisconsin-Madison, ... expand the lifespans of mice. But while testing on mice ...
... Third Wave Technologies said on Tuesday that a patent ... of its intellecual property in the U.S. , ,The patent ... analysis products with a type of chain reaction that makes ... Japanese patent for its existing Invader chemistry. , ,"These important, ...
Cached Biology Technology:
(Date:8/19/2014)... release is available in German . ... inherently intermittent energy sources. If a large amount of electricity ... future, excess energy will have to be stored during productive ... existing storage capacities are far from adequate for the purpose. ... One important focus lies on battery systems that used to ...
(Date:8/19/2014)... devised a new implantable tissue scaffold coated with bone ... weeks. When applied to bone injuries or defects, this ... bone that looks and behaves just like the original ... a dramatic improvement over the current standard for treating ... of the patient,s body a painful process that ...
(Date:8/19/2014)... in college biology and other science courses are ... ways, and now they have a new textbook ... Life Sciences," published this month by Princeton Press ... for Mathematical and Biological Synthesis (NIMBioS), teaches readers ... be used to explore and explain biological phenomena. ...
Breaking Biology News(10 mins):Asian inventions dominate energy storage systems 2Asian inventions dominate energy storage systems 3Engineering new bone growth 2Engineering new bone growth 3New textbook introduces undergraduates to mathematics for the life sciences 2
... Shakespeare. In humans, nature may be less than half of ... researchers has found. In the first study of its ... explain why human birds of a feather flock together, but ... upon the social environment in which individuals interact with one ...
... Stanford University scientists have built the first solar cell made ... used in photovoltaic devices today. The results are ... ACS Nano . "Carbon has the potential to ... author Zhenan Bao, a professor of chemical engineering at Stanford. ...
... stem cells such as regenerating damaged tissues or organs ... past decade. While these types of applications are exciting, it ... immediate impact of stem cells on human health will most ... drugs. , The ability to generate stem cells by reprogramming ...
Cached Biology News:Social factors trump genetic forces in forging friendships, CU-led study finds 2Stanford scientists build the first all-carbon solar cell 2Stanford scientists build the first all-carbon solar cell 3The role of stem cells in developing new drugs 2
... (Dual-Stage Quadrupole) Thermo Scientific (Part of ... analytical instrumentation, introduces the latest product innovation ... Based on the proven reliability and performance ... systems, the DSQ II incorporates the new ...
... variant: With the macro- and ... and Skoog (1962) and the ... et al. (1968). Preparation Quantity ... grams of powder per liter ...
... Contents include: Microarray hybridization chamber ... chamber top, clamp, thumbscrew) Microarray chamber user ... and are intended to be cleaned and ... with Agilents Catalog Oligo Microarray kits and ...
Reported to support murine B lymphocytes, hematopoietic tissue from bone marrow, B cells stimulated with lipopolysaccharide, T lymphocytes, and a variety of hybrid cells....
Biology Products: