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Scientists accelerate aging in stem cells to study age-related diseases like Parkinson's
Date:12/5/2013

t in old cells.

The researchers then used iPSC technology to reprogram skin cells taken from patients with Parkinson's disease and converted the stem cells into the type of neuron that is defective in these patients. After exposure to progerin, these neurons recapitulated disease-related features, including neuronal degeneration and cell death as well as mitochondrial defects.

"We could observe novel disease-related phenotypes that could not be modeled in previous efforts of studying Parkinson's disease in a dish," says first author Justine Miller of the Sloan-Kettering Institute for Cancer Research. "We hope that the strategy will enable mechanistic studies that could explain why a disease is late-onset. We also think that it could enable a more relevant screening platform to develop new drugs that treat late-onset diseases and prevent degeneration."


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Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert  

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