Navigation Links
Scientists accelerate aging in stem cells to study age-related diseases like Parkinson's
Date:12/5/2013

Stem cells hold promise for understanding and treating neurodegenerative diseases, but so far they have failed to accurately model disorders that occur late in life. A study published by Cell Press December 5th in the journal Cell Stem Cell has revealed a new method for converting induced pluripotent stem cells (iPSCs) into nerve cells that recapitulate features associated with aging as well as Parkinson's disease. The simple approach, which involves exposing iPSC-derived cells to a protein associated with premature aging called progerin, could enable scientists to use stem cells to model a range of late-onset disorders, opening new avenues for preventing and treating these devastating diseases.

"With current techniques, we would typically have to grow pluripotent stem cell-derived cells for 60 or more years in order to model a late-onset disease," says senior study author Lorenz Studer of the Sloan-Kettering Institute for Cancer Research. "Now, with progerin-induced aging, we can accelerate this process down to a period of a few days or weeks. This should greatly simplify the study of many late-onset diseases that are of such great burden to our aging society."

Modeling a specific patient's disease in a dish is possible with iPSC approaches, which involve taking skin cells from patients and reprogramming them to embryonic-like stem cells capable of turning into other disease-relevant cell types like neurons or blood cells. But iPSC-derived cells are immature and often take months to become functional, similar to the slow development of the human embryo. As a result of this slow maturation process, iPSC-derived cells are too young to model diseases that emerge late in life.

To overcome this hurdle, Studer and his team exposed iPSC-derived skin cells and neurons, originating from both young and old donors, to progerin. After short-term exposure to this protein, these cells showed age-associated markers that are normally presen
'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. NRL scientists demonstrate infrared light modulation with graphene
2. Scientists develop way to successfully give nanoparticle therapeutics orally
3. Biomedical Research Foundation (BRF) Recruits Two Eminent Scientists --Pradeep Garg, Ph.D., And Sudha Garg, Ph.D. -- To Run Newly-Created Louisiana Center For Molecular Imaging And Therapy
4. Scientists create perfect solution to iron out kinks in surfaces
5. Scientists invent self-healing battery electrode
6. Stanford scientists create a low-cost, long-lasting water splitter made of silicon and nickel
7. Three World-Renowned Philadelphia Scientists Are Named As Recipients Of The 2013 John Scott Award
8. Key Findings from Social Media and Email Best Practices Guide for Marketing to Life Scientists
9. Scientists Capture Most Detailed Picture Yet of Key AIDS Protein
10. UMass Amherst polymer scientists jam nanoparticles, trapping liquids in useful shapes
11. BioInformatics, LLC New Market Research Report – Social Media and Email Best Practices Guide for Marketing to Life Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists accelerate aging in stem cells to study age-related diseases like Parkinson's
(Date:9/18/2014)... developed a new microscopy technology that allows them ... higher-than-ever resolution. , Dubbed "Complementation Activated Light Microscopy" ... are an order of magnitude finer than conventional ... of biomolecules at the nanometer scale. , In ... Nature Communications , the researchers behind CALM used ...
(Date:9/18/2014)... memory device for computing may have just taken an ... New York led by chemist Stephen O,Brien have discovered ... properties. , Combining both properties is very exciting scientifically ... for the devices that might ultimately be designed, in ... a single material, however, has proved difficult until now. ...
(Date:9/18/2014)... San Diego, CA (PRWEB) September 18, 2014 ... promotions which include Sartorius/Biohit, Socorex, Capp, and ... working with volumes of 100 uL or less ... pharmaceutical, oncology, and forensic applications. , The ... of high quality and economic alternative products to ...
(Date:9/18/2014)... NY (PRWEB) September 18, 2014 Whitehouse ... negotiations with Salem Realty Group and has acquired an ... space within the Salem Executive Complex adjacent to its ... was held on Friday September 5th. Whitehouse Labs is ... the entire space specifically for package testing. The prime ...
Breaking Biology Technology:Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2Oxides discovered by CCNY team could advance memory devices 2Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 2Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 3Whitehouse Labs Announces Package Testing Laboratory Expansion 2Whitehouse Labs Announces Package Testing Laboratory Expansion 3Whitehouse Labs Announces Package Testing Laboratory Expansion 4
... - Neptune Technologies & Bioressources Inc. ("Neptune") (NASDAQ.NEPT - ... the fiscal 2009 third quarter and nine-month period ended ... for its fiscal year 2009 now ending on February, ... period ended February 28, 2009 in the range of ...
... regular improvements in information technology, says Slava Rotkin, but ... Take the laptop, for example. Its components, especially its ... while the instrument,s power and capacity increase. But heat ... melt and the laptop hardware to fail. , Indeed, ...
... Approval for SIMPONI , ... Ortho Biotech Inc. and Schering-Plough Corporation (NYSE: ... granted approval of SIMPONI (TM) (golimumab),as a once-monthly, ... active rheumatoid arthritis (RA), active psoriatic arthritis (PsA),and ...
Cached Biology Technology:Neptune Technologies to expect Record Revenues; Fiscal 2009 Third Quarter and Year-End Results 2Neptune Technologies to expect Record Revenues; Fiscal 2009 Third Quarter and Year-End Results 3Neptune Technologies to expect Record Revenues; Fiscal 2009 Third Quarter and Year-End Results 4Neptune Technologies to expect Record Revenues; Fiscal 2009 Third Quarter and Year-End Results 5New 'near-field' radiation therapy promises relief for overheating laptops 2New 'near-field' radiation therapy promises relief for overheating laptops 3Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis 2Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis 3Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis 4Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis 5Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis 6Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis 7Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis 8
(Date:9/17/2014)... as an EC-FP5 four-year project, delivering its first release ... successful participations in several EC projects, as a part ... project (EU BON), to increase the general awareness of ... the general dissemination of the Fauna Europaea results, the ... its novel e-Publishing tools to prepare data papers for ...
(Date:9/17/2014)... Copenhagen Centre for Social Evolution and Yale University offers ... weight and -length can partially predict the likelihood of ... and schizophrenia later in life. The study analyzed medical ... diagnoses for up to 30 years, and adjusted for ... published today in the Proceedings of the Royal ...
(Date:9/17/2014)... the human retinoblastoma protein gene are a leading cause ... turned to fruit fly eyes to unlock the secrets ... paper featured on the cover of the current issue ... State University researchers provide the first detailed examination of ... the human cancer gene, said Irina Pushel, MSU undergraduate ...
Breaking Biology News(10 mins):Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3Abnormal properties of cancer protein revealed in fly eyes 2
... and consume a wide range of prey, which sometimes includes ... why females eat males before or after mating. Researchers Shawn ... in a study published in the September issue of the ... than previously thought. Males are more likely to be eaten ...
... 2008)A set of stripy legs in a camera trap photo ... say researchers from the Wildlife Conservation Society. The legs belong ... the Democratic Republic of Congo,s Virunga National Park, despite over ... "This is the first time this species has been captured ...
... Ore. Contrary to 40 years of conventional wisdom, a ... Nature suggests that old growth forests are usually "carbon ... the atmosphere and mitigate climate change for centuries. However, ... by international treaties and have been considered of no significance ...
Cached Biology News:In spiders, size matters: Small males are more often meals 2Photo reveals rare okapi survived poaching onslaught 2Old growth forests are valuable carbon sinks 2Old growth forests are valuable carbon sinks 3
... and M.W. Turner (1997). ... step-by-step methods for the ... molecules, the use of ... analytical probes and as ...
Request Info...
LabFax: Immunochemistry...
Edited by P.J. Delves (1997) An up-to-date review of antibody-raising technologies, this volume provides researchers with immediate access to the protocols they require every day....
Biology Products: