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Scientists Rediscover Gene Target for Cancer Therapy
Date:12/15/2009

ancer cells is not at all surprising to scientists at Epeius Biotechnologies, who first identified the human Cyclin G1 gene as a proto-oncogene in 1994, demonstrated its therapeutic potential in a comprehensive series of landmark studies (1995-2005), and designed the sophisticated dominant-negative "knockout" construct embodied in the powerful anti-cancer agent Rexin-G (see Gordon and Hall, Intl. J. Oncology, 2009).

According to Dr. Frederick L. Hall, President and CEO of Epeius Biotech, "It is gratifying to find that functional genomics and high-throughput screening have finally served to direct basic research away from simplistic antibodies and superficial blockades of receptor-mediated pathways to the crux of the matter and the final common pathways of cell cycle control. Moreover, it is always reassuring when a basic mechanistic understanding of the logic and executive enzymology of a biochemical pathway serves to trump the rolling of dice." The finding that miR-121 targets Cyclin G1 gene expression confirms that Rexin-G may indeed be restoring a natural tumor suppressor function that is lost in the development and progression of many types of cancer; while the pathotropic (or disease-seeking) properties of Rexin-G function to deliver this agreeably rational and strategic anti-cancer agent precisely where it is needed most.

About Epeius Biotechnologies:

Epeius Biotechnologies Corporation is a privately held

SOURCE Epeius Biotechnologies Corporation
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