Navigation Links
Scientists Discover How a Bacterial Pathogen Breaks Down Barriers to Enter and Infect Cells
Date:3/7/2012

BOSTON, March 7, 2012 /PRNewswire/ -- Scientists from the Schepens Eye Research Institute, a subsidiary of Mass. Eye and Ear and affiliate of Harvard Medical School, have found for the first time that a bacterial pathogen can literally mow down protective molecules, known as mucins, on mucus membranes to enter and infect a part of the body. Their landmark study, published in the March 7, 2012 PLoS ONE, describes how they discovered that an "epidemic" strain of the bacterium Streptococcus pneumoniae, which causes conjunctivitis, secretes an enzyme to damage mucins and breach the mucosal membrane to infect and inflame the eye.

"We are excited about this finding," says Ilene Gipson, Ph.D., the study's principal investigator and a senior scientist at the Schepens. "Our discovery may ultimately lead to new ways of diagnosing, treating and preventing bacterial infections originating not only in the eye but in other parts of the body as well."

More than 80 percent of infections are contracted through the body's mucus membranes, which are the wet epithelial surfaces of the eye and the urogenital, respiratory, and gastrointestinal tracts of the body. The outer surface of all mucus membranes are protected by two types of mucin molecules – one that is secreted and is in constant motion to sweep away trapped foreign material from the membrane surface, and the other that remains rooted in the membrane surface. The latter type of mucin molecules constitutes a physical shield that keeps potentially harmful substances from penetrating the membrane.

These membranes often encounter two types of bacterial pathogens. Some are "opportunistic." They sit on the membrane surface and only enter the tissue when there is trauma or injury that leaves a gap in the mucus membrane layer. An example of an opportunistic bacterium is Staphylococcus aureus that is often the cause of surgery related infections.

The other type of p
'/>"/>

SOURCE Schepens Eye Research Institute
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Clemson scientists put a (nano) spring in their step
2. City of Hope Helps KGI Launch New Management Training Program for Scientists
3. University of Pennsylvania scientists move optical computing closer to reality
4. Scientists grow nanonets able to snare added energy transfer
5. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
6. Scientists peel away the mystery behind golds catalytic prowess
7. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
8. Vermillion and Stanford Scientists Receive Best Research Award From the PAD Coalition
9. Brewing better beer: Scientists determine the genomic origins of lager yeasts
10. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
11. CU scientists create worlds thinnest balloon -- just one atom thick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... September 18, 2014 A novel robotic ... MRI scanner is currently being tested as part of ... Hospital in Boston with the aim of determining if ... make prostate cancer biopsies faster, more accurate, less costly, ... also has the potential to deliver prostate cancer therapies ...
(Date:9/18/2014)... , September 18, 2014 ... ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the ... - Global Strategic Business Report" ... http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the worldwide ... Million by the following Product Segments: ...
(Date:9/18/2014)... On Tuesday, Secretary of Energy Ernest ... for National Lab Day on the Hill. The event ... laboratory system. Durbin and Risch also formally launched the ... of the reach of the national labs as leaders ... some of our nation's most pressing challenges. , "The ...
(Date:9/18/2014)... Sept. 18, 2014 Research and ... "Global N-acetylcysteine Industry Report 2014" report ... N-acetylcysteine Industry Report 2014 is a professional and ... global N-acetylcysteine industry. The report provides ... classifications, applications and industry chain structure. The N-acetylcysteine ...
Breaking Biology Technology:Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global N-acetylcysteine Industry Report 2014 2
... Inc. (NYSE: WST ) today announced that management will be ... CJS Securities, Ninth Annual "New Ideas for the ... 1:55pm on Wednesday, January 7, 2009. , ... Sidoti & Company,s Sixth Annual Palm Beach Emerging Growth ...
... , ... (PRWEB) December 17, 2008 -- Facilitating the entry ... modern protocol analyzer, now updated to effortlessly examine not only the ... telephone modem, but also the interface between the device CPU and ...
... 2008 , - Evaluation of strategic alternatives on-going , - ... 5 ADVENTRX Pharmaceuticals, Inc. (NYSE Alternext US: ANX) announced ... effort to extend its remaining cash and to prepare itself ... in October 2008. In all, the Company,s workforce has ...
Cached Biology Technology:West to Present at Upcoming Conferences 2Newly Available To Medical Device Manufacturers - Bluetooth Testing Equipment 2Newly Available To Medical Device Manufacturers - Bluetooth Testing Equipment 3ADVENTRX Announces Further Cost-Cutting Measures 2ADVENTRX Announces Further Cost-Cutting Measures 3ADVENTRX Announces Further Cost-Cutting Measures 4ADVENTRX Announces Further Cost-Cutting Measures 5
(Date:9/19/2014)... unveiled today by researchers from several Harvard University ... both experienced and aspiring researchers with the intellectual ... robots made from soft, flexible materials. , With ... and other advances in manufacturing technology, soft robotics ... principles drawn from conventional rigid robot design, but ...
(Date:9/19/2014)... Imagine you are a species which over thousands of years ... exposed to a substance that makes the cold dangerous for ... Enchytraeus albidus , and the cold provoking substance, called ... cosmetics. , Nonylphenol is suspected of being a endocrine disruptor, ... It inhibits the worm,s ability to protect the cells in ...
(Date:9/18/2014)... new GSA Bulletin study uses tree rings ... and Chaco Wash in northern New Mexico, USA. By ... and willow, investigators were able to precisely date arroyo ... combined this data with aerial imagery, LiDAR, longitudinal profiles, ... arroyos. , Arroyos are deep, oversized channels that have ...
Breaking Biology News(10 mins):Soft robotics 'toolkit' features everything a robot-maker needs 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7
... Darrel Jenerette, a landscape ecologist at UC Riverside, is ... will be investigating human vulnerability to deadly heat exposure. ... heat island" a metropolitan area that is much warmer ... risks, as well as how human decisions lead to this ...
... to the toxic chemicals, such as methylmercury can cause ... of the epidemiological evidence in the International Journal ... take a precautionary approach to this and similar compounds ... Philippe Grandjean of the Department of Environmental Health at ...
... for a long time that the plant hormone auxin is ... and that the local concentration of auxin is important for ... sprouting of shoots. To name a few things; auxin is ... clinging of climbers and a series of other processes. Thousands ...
Cached Biology News:UC Riverside scientist to explore how vegetation affects urban heat islands 2Methylmercury warning 2Scientists unveil mechanism for 'up and down' in plants 2
Automated Cell Culture Flask...
Cell Culture Flask, 75 cm, treated polystyrene...
... style shaker flasks have three extra deep ... solutions to improve oxygen or gas transfer ... The long neck reduces splashing and is ... wall thickness provides the proper balance between ...
... IS System is a compact analysis system for ... optics, fluidics, a controller, advanced digital signal processing ... lab analysis system includes the Luminex 100, the ... a DMF file at the FDA, and partner ...
Biology Products: