Navigation Links
Scientists Discover How a Bacterial Pathogen Breaks Down Barriers to Enter and Infect Cells
Date:3/7/2012

BOSTON, March 7, 2012 /PRNewswire/ -- Scientists from the Schepens Eye Research Institute, a subsidiary of Mass. Eye and Ear and affiliate of Harvard Medical School, have found for the first time that a bacterial pathogen can literally mow down protective molecules, known as mucins, on mucus membranes to enter and infect a part of the body. Their landmark study, published in the March 7, 2012 PLoS ONE, describes how they discovered that an "epidemic" strain of the bacterium Streptococcus pneumoniae, which causes conjunctivitis, secretes an enzyme to damage mucins and breach the mucosal membrane to infect and inflame the eye.

"We are excited about this finding," says Ilene Gipson, Ph.D., the study's principal investigator and a senior scientist at the Schepens. "Our discovery may ultimately lead to new ways of diagnosing, treating and preventing bacterial infections originating not only in the eye but in other parts of the body as well."

More than 80 percent of infections are contracted through the body's mucus membranes, which are the wet epithelial surfaces of the eye and the urogenital, respiratory, and gastrointestinal tracts of the body. The outer surface of all mucus membranes are protected by two types of mucin molecules – one that is secreted and is in constant motion to sweep away trapped foreign material from the membrane surface, and the other that remains rooted in the membrane surface. The latter type of mucin molecules constitutes a physical shield that keeps potentially harmful substances from penetrating the membrane.

These membranes often encounter two types of bacterial pathogens. Some are "opportunistic." They sit on the membrane surface and only enter the tissue when there is trauma or injury that leaves a gap in the mucus membrane layer. An example of an opportunistic bacterium is Staphylococcus aureus that is often the cause of surgery related infections.

The other type of p
'/>"/>

SOURCE Schepens Eye Research Institute
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Clemson scientists put a (nano) spring in their step
2. City of Hope Helps KGI Launch New Management Training Program for Scientists
3. University of Pennsylvania scientists move optical computing closer to reality
4. Scientists grow nanonets able to snare added energy transfer
5. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
6. Scientists peel away the mystery behind golds catalytic prowess
7. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
8. Vermillion and Stanford Scientists Receive Best Research Award From the PAD Coalition
9. Brewing better beer: Scientists determine the genomic origins of lager yeasts
10. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
11. CU scientists create worlds thinnest balloon -- just one atom thick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... news release is available in German . ... crystal around several quantum dots in a semiconductor layer. Quantum ... consequence of atomic processes. If a short laser pulse is ... and the quantum dot experiences a change in the electromagnetic ... down the emission of light by the dot. As soon ...
(Date:9/30/2014)... of one of nature,s most efficient light-harvesting structures, ... by Alejandro Briseno of the University of Massachusetts ... long-sought polymer architecture to boost power-conversion efficiency of ... , Briseno, with colleagues and graduate students ... and Dresden University of Technology, Germany, report in ...
(Date:9/30/2014)... September 30, 2014 Shimadzu Scientific ... an easy-to-use and highly precise tool for measuring ... considerable elongation. With 1000-mm maximum movement distance, the ... for a gauge length of 10 mm. In ... accuracy above 50-mm stroke and within +/- 100 ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Proove ... medicine, is excited to announce a new genetic test ... The Proove Pain Perception Test will provide physicians ... and why pain tolerance levels are stratified between individuals. ... identify whether a person has a genetic predisposition that ...
Breaking Biology Technology:Ultrafast remote switching of light emission 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3
... "gecko foot" dry adhesive got a new competitor this week ... journal Science by a team of researchers from four U.S. ... of gecko lizards to scurry up walls and cling to ... ability to microscopic branched elastic hairs in their toes that ...
... SAN DIEGO, Oct. 9 CardioDynamics (Nasdaq:,CDIC), the innovator ... financial results for fiscal third quarter 2008., ... Quarter 2007 -- Net ICG sales increased 8% ... International sales increased 35% to $690,000, up from $513,000 ...
... 9 /PRNewswire-FirstCall/ - Dr. Brad Thompson, President,and CEO ... will present a,corporate overview of the Company at ... on Monday, October 13 at 2 p.m. The ... Conference Centre from October,12-14, 2008., About Oncolytics ...
Cached Biology Technology:Dry adhesive based on carbon nanotubes gets stronger, with directional gripping ability 2Dry adhesive based on carbon nanotubes gets stronger, with directional gripping ability 3Dry adhesive based on carbon nanotubes gets stronger, with directional gripping ability 4CardioDynamics Reports Third Quarter 2008 Results, Seventh Consecutive Quarterly Revenue Growth and 15% Year to Date Revenue Increase 2CardioDynamics Reports Third Quarter 2008 Results, Seventh Consecutive Quarterly Revenue Growth and 15% Year to Date Revenue Increase 3CardioDynamics Reports Third Quarter 2008 Results, Seventh Consecutive Quarterly Revenue Growth and 15% Year to Date Revenue Increase 4CardioDynamics Reports Third Quarter 2008 Results, Seventh Consecutive Quarterly Revenue Growth and 15% Year to Date Revenue Increase 5CardioDynamics Reports Third Quarter 2008 Results, Seventh Consecutive Quarterly Revenue Growth and 15% Year to Date Revenue Increase 6Media Advisory - Oncolytics Biotech Inc. to Present at BioPartnering Europe 2
(Date:9/30/2014)... have in common? Unlike most eukaryotic multicellular organisms ... these organisms are all polyploid, meaning they have three ... 3 and 4 sets of chromosomes, respectively, and strawberries ... fact most plant species are polyploid. Polyploidy, or genome ... only recently, with the development of molecular tools, has ...
(Date:9/30/2014)... drinking water may increase the risk of stillbirth ... led by a Boston University School of Public ... journal Environmental Health , compared 1,091 PCE-exposed ... in Cape Cod, Ma., where water was contaminated ... by the installation of vinyl-lined asbestos cement pipes. ...
(Date:9/30/2014)... comes to using marijuana, new research, involving mice and ... Journal of Leukocyte Biology , suggests that ... you should. That,s because a team of Italian scientists ... serious long-term damage to the immune system. This damage ... such as multiple sclerosis, inflammatory bowel disease and rheumatoid ...
Breaking Biology News(10 mins):Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Contaminated water linked to pregnancy complications, BU study finds 2Adolescent exposure to thc may cause immune systems to go up in smoke 2
... 12, 2008 Tiny organisms play a powerful role in ... activity, in streams, according to a study by a team ... In the first phase of the study, which involved ... small amounts of an uncommon non-radioactive isotope of nitrogen to ...
... 12, 2008 -- Noted green energy entrepreneur K.R. Sridhar ... Venture Challenge, a business competition and venture forum to ... The focus of this years event is on ... and power generation sectors. Sridhar, CEO of Bloom ...
... vibrant ecosystems play a critical role in removing excess ... new national study published this week in Nature. ... across the United States, was the first to document ... filter through tiny organisms or release into the atmosphere ...
Cached Biology News:ORNL study finds rivers play part in removing nitrogen 2Healthy rivers needed to remove nitrogen 2Healthy rivers needed to remove nitrogen 3
Mouse Anti-Human Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4 Monoclonal Antibody Family: New...
Gridded Cell Culture Petri Dish (20 mm molded in base), tissue-culture treated...
...
BD Biocoat Matrigel Matrix Thin Layer 35 mm Culture Dishes...
Biology Products: